In graph theory, the problem of finding minimum vertex separator (MVS) is a classic NP-hard problem, and it plays a key role in a number of important applications in practice. The real-world massive graphs are of very large size, which calls for effective approximate methods, especially heuristic search algorithms. In this article, we present a simple yet effective heuristic search algorithm dubbed HSMVS for solving MVS on real-world massive graphs. Our HSMVS algorithm is developed on the basis of an efficient construction procedure and a simple yet effective vertex-selection heuristic. Experimental results on a large number of real-world massive graphs present that HSMVS is able to find much smaller vertex separators than three effective heuristic search algorithms, indicating the effectiveness of HSMVS. Further empirical analyses confirm the effectiveness of the underlying components in our proposed algorithm.