Effect Of Trimebutine Maleate Research Articles

Effect of Trimebutine maleate on reflux esophagitis in elderly patients

Objective To investigate the effect of Trimebutine maleate on reflux esophagitis in elderly patients. Methods A total of 160 elderly patients with typical esophageal reflux symptoms diagnosed as reflux esophagitis by gastroscope, with concomitant gastroesophageal disease confirmed by esophageal motility manometry and 24 h esophageal pH impedance monitoring acid reflux, were selected and retrospectively analyzed. All patients were treated with proton pump inhibitor(PPI)esomeprazole 20 mg tid, antecibum(AC)for 8 weeks, and randomly divided into four groups: group A(itopride hydrochloride 50 mg tid, AC), group B(citrate mosapride 5 mg tid, AC), group C(trimebutine maleate 200 mg tid, AC), group D(treated without prokinetic drugs). After 4 and 8 weeks of therapy, the symptom improvements were observed in the four groups. Endoscopy, esophageal motility manometry, 24h esophageal pH impedance monitoring were performed in the 160 cases after 8 weeks of treatment. Results The total effective rate was 97.5%(39 cases), 95.0%(38 cases), 92.5%(37 cases)and 77.5%(31 cases)in group A, B, C and D respectively after 8 weeks of treatment. Endoscopic examination showed that the cure rate was 70.0%(28 cases), 62.5%(25 cases), 72.5%(29 cases), 67.5%(27 cases), and the effective rate was 87.5%, (35 cases), 92.5%(37 cases), 87.5%(35 cases)and 87.5%(35 cases)in group A, B, C and D respectively after 8 weeks of treatment, without statistically significant differences in the cure rate and effective rate between the four groups. The results of esophageal motility manometry showed that the lower esophageal sphincter pressure(LESP), lower esophageal sphincter relaxation(LESR), lower esophageal peristaltic wave pressure(LEPP)and percentage of abnormal esophageal body contraction had significant difference before versus after treatment in group A and B, but not in control group. The improvements in the percentage of total time of pH 5 min, the longest reflux time(min)at supine position were more significant in group A, B and C than in group D. Compared with pre-treatment, the times of non-acid reflux were reduced significantly in group A, B and D(all P<0.01), and there was a significant difference(P<0.05)between the three(A, B, C)groups and group D(P<0.05). There were significant differences in the times of reflux liquid and gas reflux between the group A, B and D(P<0.05). The proximal reflux times were improved more significantly in group A, B and C after treatment than in control group(P<0.05). Conclusions Prokinetic drugs combined with PPI therapy has better effect than single PPI application in improving the clinical symptoms and upper gastrointestinal motility in elderly patients with RE. Trimebutine maleate is safe and effective in the elderly, and has a similar effect on esophageal motility with mosapride citrate and itopride hydrochloride, which may be involved in selectively improving esophageal motility, lower esophageal sphincter pressure and gastric emptying function. Key words: Esophagitis, peptic; Trimebutine maleate; Proton pump inhibitors

Duodenogastric reflux following cholecystectomy in the dog: role of antroduodenal motor function.

Duodenogastric reflux has been implicated in the pathogenesis of gastric ulcer and gastritis. Duodenogastric reflux after cholecystectomy is also a possible cause of post-cholecystectomy syndrome. To investigate the role of antroduodenal motor function in increased duodenogastric reflux following cholecystectomy and the effect of trimebutine maleate (trimebutine) on the duodenogastric reflux in conscious dogs. Antropyloric and duodenal motility and bile acids content in the gastric juice were measured for 3 h during the inter-digestive state in dogs with or without cholecystectomy. Bile acids content in the gastric juice of cholecystectomized dogs was significantly higher than that of non-cholecystectomized dogs. The frequency of pyloric relaxation during phase II of the migrating motor complex was significantly increased following cholecystectomy. Intravenous infusion of trimebutine inhibited both the increased duodenogastric reflux and the frequency of pyloric relaxation in the cholecystectomized dog. Duodenogastric reflux and frequency of pyloric relaxations were increased in cholecystectomized dogs and trimebutine suppressed both of them. These findings suggest that the increased frequency of pyloric relaxation contributes to the duodenogastric reflux following cholecystectomy.

Effect of trimebutine maleate on experimental colitis in rats

Effect of trimebutine maleate on experimental colitis in rats

Effect of trimebutine maleate on the contractile response of the isolated ileum from diabetic rats

1. 1. Tension of the isolated ileum from diabetic rats induced by streptozotocin was measured isometrically to study the mode of action of trimebutine maleate (TMB). 2. 2. The hyperreactivity of contractile response to KCl was observed in the isolated ileum from diabetic rats. TMB inhibited the contraction induced by KCl and acetylcholine (ACh) in normal solution. 3. 3. In Ca 2+ free solution, the hyperreactivity of contractile response to KCl was attenuated, and TMB did not inhibit the contraction induced by KCl. In contrast, TMB inhibited the contraction induced by ACh even in Ca 2+ free solution. 4. 4. These results suggest that the hyperreactivity of contractile response to KCl in the ileum from diabetic rats is due to the enhancement of Ca 2+ influx through voltage-dependent Ca 2+ channel and that TMB inhibits the hyperreactivity of contractile response through the inhibition of Ca 2+ movement by the cell.

P-60 - Effect of trimebutine maleate on hyperreactivity in isolated ileum from diabetic rats.

P-60 - Effect of trimebutine maleate on hyperreactivity in isolated ileum from diabetic rats.

O-228 - Effect of trimebutine maleate on gastric motility in rats

O-228 - Effect of trimebutine maleate on gastric motility in rats

Effect of Trimebutine Maleate on Diabetic Diarrhea

Effect of Trimebutine Maleate on Diabetic Diarrhea

Ｔｒｉｍｅｂｕｔｉｎｅ ｍａｌｅａｔｅのほ乳動物摘出心筋に及ぼす電気生理学的抑制効果

Ｔｒｉｍｅｂｕｔｉｎｅ ｍａｌｅａｔｅのほ乳動物摘出心筋に及ぼす電気生理学的抑制効果

EFFECT OF TRIMEBUTINE MALEATE ON BETHANECHOL-INDUCED CONTRACTIONS OF GASTROINTESTINAL TRACT IN CONSCIOUS AND ANAESTHETIZED DOGS

The effect of trimebutine maleate (TM-906) on bethanechol-induced contractions of the gastrointestinal tract in dogs was studied by means of chronically implanted force transducers, and it was compared with that of metoclopramide and atropine. During the period of motor quiescence in the fasted state of conscious dog, a bolus i.v. injection of 10 to 50 μg/kg bethanechol caused rhythmic contractions in the stomach and small intestine, in which an increase in basal tone was often accompanied in the distal ileum. The stomach responded to a less extent than the small intestine. Intravenous infusion of TM-906 at 3.0 mg/kg-hr for 20 to 60 min reduced the gastric contractions induced by 20 to 30 μg/kg bethanechol in five out of six conscious animals examined. The drug, however, enhanced the contractions of the duodenum and jejunum in a majority of the animals. Metoclopramide (1.8 mg/kg-hr) showed a tendency to potentiate the bethanechol-induced contractions in the stomach and small intestine, and atropine (0.06 mg/kg-hr) diminished them. In pentobarbital-Na anaesthetized dogs, effects of TM-906 on bethanechol-induced contractions resembled those in conscious dogs, inhibition in the stomach and potentiation in the small intestine.