Effect Of Stabilizers Research Articles

Effect of stabilizers on the detection of swine influenza A virus (swIAV) in spiked oral fluids over time.

Aggregated samples such as oral fluids (OFs) display an animal friendly and time and cost-efficient sample type for swine Influenza A virus (swIAV) monitoring. However, further molecular and biological characterization of swIAV is of particular significance. The reportedly inferior suitability of aggregated samples for subtyping of swIAV presents a major drawback compared to nasal swabs, still considered the most appropriate sample type for this purpose (Garrido-Mantilla et al. BMC Vet Res 15(1):61, 2019). In addition, the viral load in the original sample, storage conditions and characteristics of different swIAV strains might further compromise the eligibility of aggregated samples for molecular detection and subtyping. Therefore, the present study aimed to evaluate the suitability of stabilizing media to minimize the degradation of viral RNA and thus increase the detection and subtyping rate of swIAV by RT-qPCR in spiked OFs under different conditions (virus strain, storage temperature and viral load in the original sample) over a time span of 14days. The use of stabilizing media in spiked OFs resulted in a significant higher probability to detect swIAV RNA compared to OFs without stabilizers (OR = 46.1, p < 0.001). In addition,swIAV degradation over time was significantly reduced in samples suspended with stabilizer (OR = 5.80, p < 0.001), in samples stored at 4°C (OR = 2.53, p < 0.001) and in samples spiked with the avian derived H1N2 subtype (OR = 2.26, p < 0.01). No significant differences in swIAV RNA detection and degradation of swIAV RNA in spiked OFs over time were observed between the three different stabilizing media. Addition of stabilizers and storage of samples under cooled conditions significantly improved detection and subtyping of swIAV in spiked OFs.

On the Effect of Current Stabilizer on Dynamics of a Small Hybrid Wind Power Generator

The use of small wind power generators remains quite relevant. In particular, they can be efficient for charging batteries in remote locations where there is no centralized power supply (including in the Arctic, Far East, etc.). They can also be used as part of missions to planets with atmospheres. One of the promising design solutions for a small wind power generator with a vertical axis of rotation is a hybrid device. It consists of two wind turbines that have a common axis of rotation: external (Darrieus wind turbine) and internal (Savonius rotor). This scheme represents a compromise between the relatively high power coefficient of the Darrieus turbine and the good startup characteristics the Savonius rotor. It is known that one of the typical battery charging modes is constant current charging. Here we consider a hybrid installation, the generator of which is connected to a current stabilizer. The load is simulated with an active resistance. It is assumed that the generator is a DC generator. A closed mathematical model of the studied system is constructed. The aerodynamic load is described using the quasi-steady approach. It is assumed that the characteristic time of electrical processes is much smaller than the characteristic time of mechanical processes. The influence of load resistance on the behavior of the system is investigated. It is shown that, under certain conditions, several steady modes (up to five) exist in the system. In this case, at least two of them are attracting. Therefore, the hysteresis of the angular speed of the steady mode is possible when the load resistance changes. It should be noted that in a number of situations, an unstable steady mode (which corresponds to a lower angular speed of the turbine than a stable one) may be preferable (for example, to reduce the load on bearings). In this regard, a resistance control strategy has been proposed to ensure stabilization of the unstable stationary regime.

Effect of ionic soil stabilizer on the properties of lime and fly ash stabilized iron tailings as pavement base

The large use of iron tailings is in urgent need given its huge emissions and pollution to environment. This paper sought to utilize a large quantity of iron tailings with fly ash and lime to prepare road base materials, and use ionic soil stabilizer (ISS) to improve its pavement performance. Different dosage ISS content of was added to the lime-fly ash stabilized iron tailing materials to improve the mechanical strength, frost resistance properties and decrease the dry shrinkage. The results show that the UCS of the specimen with 0.67 % ISS represents enhancement of 195.5 % compared to the control sample at 7 d. After undergoing 15 freeze-thaw cycles, the residual UCS ratio remains at 76.6 %, whereas the control sample exhibits signs of failure. Additionally, the dry shrinkage strain at 30 d was 66.3 % lower than that of the control sample without ISS. The mechanisms underlie that the adsorbed ISS onto iron tailings can reduce the repulsion between total fine particles by lowering the general zeta potential, thus decreasing the porosity of the road base materials. Besides, the ISS can hinder the phase transformation from ettringite (AFt) to monosulfoaluminate (AFm) and its hydrophobic groups can prevent the infiltration and migration of water. The findings reveal that ISS significantly enhances the pavement performance of the stabilized iron tailings, thereby presenting a novel approach for the incorporation of iron tailings in road construction endeavors.

Effects of foam stabilizers on the properties and microstructure of autoclaved aerated concrete from iron tailings

Effects of foam stabilizers on the properties and microstructure of autoclaved aerated concrete from iron tailings

Effects of silicate stabilizers on cadmium reduction and the quality of rice grains in acidic paddy soil

Silicate has been proven to be highly-effective at immobilizing soil heavy metals, but the effects of silicate stabilizers on rice grain cadmium (Cd) reduction and rice quality under field conditions are not clear. In this study, a field experiment was conducted over three consecutive years was conducted to examine the Cd reduction in rice grains and to reveal the potential effects of silicate stabilizers on rice grain nutrients, by setting different amounts of bentonite (B), silica‒calcium fertilizer (SC) and zeolite powder (ZP). The results revealed that the application of the B, SC and ZP significantly decreased the soil CaCl2‒Cd concentration (> 39%) and significantly reduced the grain Cd concentration in both early rice (> 70%) and late rice (> 18%) under field conditions; the silicate stabilizers reduced the soil available iron (Fe) but did not limit rice grain Fe nutrition. Additionally, the three silicates promoted rice yield and improved the rice grain Ca and Mg contents; and the application of B increased the amylose concentration of the late rice grains. In conclusion, high amounts of silicate stabilizers did not adversely influence the soil conventional nutrient indices, rice minerals or rice taste, but changes in rice selenium content need attention. Overall, in comparison with lime, silicate stabilizers can improve not only the safety of rice but also the nutritional and taste qualities of rice and are more eco-friendly for long-term use in soil.

The Effects of Organic, Inorganic, and Microbiological Stabilizers on the Transfer of Arsenic and Heavy Metals to Rice Plant

The Effects of Organic, Inorganic, and Microbiological Stabilizers on the Transfer of Arsenic and Heavy Metals to Rice Plant

Flutter performance of a suspension bridge equipped with separated oblique stabilizers covering different span lengths

Vertical stabilizers have been proved to be effective for flutter suppression of long-span bridges, while their self-stability under strong winds should be taken seriously. This study takes a steel truss stiffening girder as an example, and effects of oblique stabilizers on the flutter performance are investigated. After discussing the wind environment above the bridge site, the flutter derivatives of girder extracted by numerical simulations are given to compute the critical flutter wind speed by a bimodal coupled flutter analysis method. Subsequently, with considering the lateral self-excited force, the flutter performance is accurately evaluated by performing complex modal characteristics based on a full-order modal flutter analysis method. After setting different types of stabilizers with different covering lengths, improvement of the flutter performance is discussed. The results show that the flutter performance is related to multiple modes. Temporary flutter instability of a modal branch may be caused due to the curve-veering phenomenon among similar modes. Thus, the critical flutter wind speed may be overestimated by bimodal-coupled flutter analyses. At negative angles of attack, the set of oblique stabilizers are flutter favorable by improving the temporary flutter instability. Setting partial stabilizers around the mid-span is more flutter favorable than covering the entire girder.

Effects of optimizing fermentation time and stabilizers using response surface methodology on physicochemical properties of camel milk yoghurt

The objective of this study was to produce camel milk yoghurt with desired qualities using optimized processing conditions (fermentation time) and ingredients (stabilizer and calcium chloride). The conditions were obtained through Response Surface Methodology (RSM) by lactic acid fermentation by inoculating the milk with Lactobacillus delbrueckii subsp. Bulgaricus (YF-L903, CHR Hansen, Denmark. The study also determined the effects of fermentation time and ingredients on the quality of yoghurt. Fermentation time ranged from 2 to 22 h while stabilizer (corn starch) and calcium chloride (salt) ranges were 1.65–3.34 and 0.061–1.23 % respectively. The quality was monitored hourly for a fermentation period of 2–22 h by determining pH, total titritable acidity (TTA) and viscosity. Results indicated that viscosity was influenced by fermentation time, stabilizer and calcium chloride. The viscosity was increased from 0.01 to 0.4 and 0.01 to 0.3 by fermentation time, 0.01 to 0.2 and 0.01 to 0.3 by stabilizer and 0.01 to 0.5 and 0.01 to 0.6 Pa s by calcium chloride. Whereas the combined effects of calcium chloride and stabilizer increased the viscosity of yoghurt to 0.94 Pa s. Prolonged fermentation time, led to an increase in TTA and a decrease in pH. The finding from this study indicated that the optimal conditions required to produce camel milk yoghurt with desired qualities are a fermentation time of 10 h using 2.33 and 0.60 % corn starch and calcium chloride respectively. Under these conditions the produced camel milk yoghurt quality properties were a pH of 4.07, 0.32 % TTA and a viscosity of 0.35 Pa s.

Experimental study on preparation of solidified soil from residue of construction waste

This study investigates the stabilization effect of a new soil stabilizer based on mineral powder, lime powder, dihydrate gypsum, and sodium hydroxide on the residue of construction waste (RCW). The performance of the residue solidified soil (RSS) with different ratios of stabilizer was analyzed both macroscopically and microscopically, in air and water environments.The experiment indicates that the optimal composition of the new stabilizer for specimen a7 consists of 85 % mineral powder, 3 % sodium hydroxide, and 12 % dihydrate gypsum. The water stability coefficients of specimens a3-a10 are all greater than 80 %.The performance of RSS meets the requirements of the Technical standard for application of soil stabilizer (CJJ/T286- 2018) and the technical specificatiopn for application of road solidified soil (T/CECS 737–2020). Therefore, the RSS designed and prepared in this study is a material with sufficient strength that can be used for urban road subbase layers. From a microscopic perspective, the generation of a large amount of ettringite crystals and C-S-H gel is the main reason for the increase in compressive strength of stabilized soil as it ages.The cost benefit analysis of the RSS that meets the strength requirements is carried out. The performance and cost of the RSS is also compared with the ones solidified by Portland cement and sulphoaluminate cement. From the economic point of view, most of the raw materials of the new soil stabilizer are cheap and easy to obtain, and the cost of the new soil stabilizer is much lower than that of Portland cement and sulphoaluminate cement, therefore the RSS should have strong market competitiveness.

The Effect of Different Stabilizers on the Characteristics of Gluten-Free Dried Noodle from Arrowroot and Mung bean Flour

Dry noodles are one of the foods made from wheat flour. The availability of wheat in Indonesia does not match consumer demand, necessitating the use of alternative ingredients such as arrowroot flour and mung bean flour. The use of stabilizers like CMC, STPP, and Xanthan Gum is needed to improve the characteristics of dry noodles. This research aims to determine the effect of the proportion of arrowroot flour and mung bean flour with different types of stabilizers on the physicochemical and organoleptic characteristics of dry noodles. The experimental design used was a factorial CRD with two factors. Factor I was the proportion of arrowroot flour and mung bean flour and Factor II was the addition of different types of stabilizers. Data were analyzed using 5% ANOVA and 5% DMRT. There was a significant interaction (p≤0.05) on the moisture content, ash, protein, fat, starch, rehydration capacity, cooking loss, elasticity, and organoleptic characteristics of aroma, texture, and overall appearance. There were no significant differences in the organoleptic characteristics of color and taste. The best treatment was the proportion of arrowroot flour and mung bean flour (60:40) with the addition of CMC stabilizer, which resulted in dry noodles with the following characteristics: moisture 11.392%, ash 1.919%, protein 11.592%, fat 1.378%, starch 54.720%, rehydration capacity 110.266%, cooking loss 6.398%, elasticity 0.314 N, aroma 4.200, color 4.040, taste 3.800, texture 4.200, and overall appearance 4.160.

Numerical and Experimental Analysis of Lifting Forces of Fin Stabilizers with Fin–Hull Interaction

A fin stabilizer is one of the most effective and frequently used anti-roll devices for maintaining a ship’s operational safety and passengers’ comfort. However, the discrepancy between theoretical hydrofoil-based predictions and the actual dynamic lift force of fin stabilizers due to fin–hull interactions requires more research attention. This study investigates the effect of fin stabilizers on mitigating roll motion through the performance of extensive computational fluid dynamic (CFD) simulations over a range of fin angles and ship speeds. Model tests were carried out to validate the drag and motion results obtained from numerical analyses. The results show that fin stabilizers significantly reduce the roll motion, with the lift coefficient values influenced by the Reynolds number, leading to differences between the theoretical and Reynolds-averaged Navier–Stokes (RANS) calculations. At a high Froude number (Fr), the actual fin lift is about half of the theoretical value. These findings highlight the requirement of selecting an adequate fin area at the predominant ship speeds and ensuring an effective anti-roll effect with fin–hull interaction. This study provides a significant reference for ship design, as well as stabilization system control and optimization.

Modelling the Color and Microbial Properties of Canned Ngu by Response Surface Method

Background: Ngu is an African salad dressing used to improve the stability and shelf life of African salad. The aim of this study was to produce canned Ngu using three stabilizers at various concentrations, constant sterilization temperature, and varied sterilization times. Methods: Ngu (50 L) was prepared from potash using three stabilizers at various concentrations. A three-level factorial response surface design was applied to generate the experimental runs for the production of the canned Ngu. The Ngu emulsion was filled inside 250 ml bottle jars, sterilized at 121 oC at various times, and canned. The color of the canned Ngu was evaluated using the Comission Internationale de l'Eclairage color scale, and its microbiological attributes, Total Viable Count (TVC) and Total Fungal Count was determined with standard procedures. The effect of the stabilizers (Akparata, Ofo, and Carboxyl Methyl Cellulose), stabilizer concentration, and sterilization time on the color and microbial properties of the canned Ngu was assessed. The Statistical Software Design Expert version 8.0.7 was utilized for response surface analysis and derivation of model equation. Results: Increase in sterilization time increased the a* value and decreased the b* value of the canned Ngu. The quadratic effect of stabilizer, stabilizer concentration, and sterilization time indicated that the alteration of stabilizer from Carboxyl Methyl Cellulose to Akparata and then to Ofo increased the L* value, of the canned Ngu. An increase in the quadratic effect of stabilizer concentration increased the a* value but decreased the L* and b* values of the canned Ngu. However, the TVC and b* value of the canned Ngu reduced as the quadratic effects of the sterilization time increased. Conclusion: Total Fungal Count and TVC value of all the canned Ngu samples were within acceptable limits, ensuring the samples safe for human consumption.

A simple testing-analysis method to evaluate the mechanical characteristics of soils under cyclic loading

ABSTRACT This study presents a simple, yet robust testing methodology employed for investigating the mechanical behaviour of soils under cyclic loading conditions. Small cylindrical specimens of soil (10.5 mm diameter and 35.0 mm high) were subjected to oscillatory torsional loading in either strain sweep or stress sweep mode using the dynamic shear rheometer. Key mechanical properties, including dynamic shear modulus, phase angle, and energy dissipation capacity, were obtained and used to effectively identify threshold strain levels which differentiated the linear, nonlinear, and damage response of the soil. This study further applied the proposed method to stabilized soils to evaluate the effects of stabilizers on improving soil stiffness, while also considering their potential effects on increasing soil brittleness, which could ultimately lead to reduced resistance to fatigue cracking. The successful development of this testing protocol has the potential to evolve into a specification-type method due to its efficiency, repeatability, sensitivity, and fundamental robustness.

Effect of hydrolysis stabilizers on anti-aging performance of PET under pressure cooker test

Polyethylene terephthalate (PET) is extensively utilized in various industries due to its good properties. However, as a kind of polyester, PET is apt to hydrolysis when exposed to moisture and heat, which severely affects its performance and service life. Hence, the incorporation of hydrolysis stabilizers is a common mitigation method. In this work, the PET specimens modified by two types of hydrolysis stabilizers were subjected to the pressure cooker test to evaluate the improvement effect, and the resultant changes in appearance, mechanical properties, and thermal characteristics were studied. Additionally, the crystallinity and infrared peaks were detected to assess the effectiveness of the hydrolysis stabilizers and to reveal the aging mechanisms of PET. The results indicated that PET underwent three distinct aging processes during the pressure cooker test, including crystallization, water plasticization and hydrolysis, and the inhibitory effect of the hydrolysis stabilizers mainly reflected in the crystallization and hydrolysis processes while the effectiveness depended on their types and concentrations.

Environmentally friendly fluorine-free fire extinguishing agent based on the synergistic effect of silicone, hydrocarbon surfactants and foam stabilizers

The environmentally friendly fluorine-free fire extinguishing agent based on the silicone surfactant was developed in order to solve the environmental hazards and bio-accumulative of traditional aqueous film-forming foam (AFFF). The carboxyl modified polyether polysiloxane surfactant (CMPS) was an efficient alternative to fluorocarbon surfactant, which was firstly synthesized via the esterification reaction using hydroxyl-containing polyether modified polysiloxane (HPMS) and maleic anhydride (MA) as raw materials. Then the surface activity, foam properties, micellar morphology of the CMPS and four hydrocarbon surfactants, as well as their mixture are evaluated by surface tension, Ross-Miles and cryo-transmission electron microscopy (Cryo-TEM). And the suitable key amount of CMPS and hydrocarbon surfactants added to the extinguishing agent were optimized by orthogonal tests. Moreover, the effect of foam stabilizer on the surface activity, foam property and fire extinguishing performance of fire extinguishing agent are also analyzed. Consequently, a new environmentally friendly fluorine-free fire extinguishing agent was prepared and the surface tension, the interfacial tension, foam properties, bubble morphology, spreading behavior and fire extinguishing mechanism were systematically characterized. The Cryo-TEM results illustrate that the intense interaction among silicone and hydrocarbon molecules exists in the the mixture of CMPS and hydrocarbon surfactants, which is produced through the change of micellar morphology, i.e. microscopic larger spheroidal micelles of CMPS transited to smaller spheroidal micelles and wormlike micelles in the mixed system. The surface tension of synthesized foam extinguishing agent is 22.3 mN/m and the spread coefficient is 0.9 mN/m, which has excellent surface activity and spreading property. The prepared foam extinguishing agent exhibits superior fire-fighting property, which can be attributed to the high surface activity, good foam property and superior foam stability. The research results of this paper lay a theoretical foundation for the research and development of efficient environmentally friendly foam extinguishing agent.

Effects of Mood Stabilizers on Sleep and Circadian Rhythms: A Systematic Review

Effects of Mood Stabilizers on Sleep and Circadian Rhythms: A Systematic Review

Quality Characteristics of Jack Bean (Canavalia ensiformis L.) Tempeh Milk with Addition of Ajwa Date (Phoenix dactylifera L.) and Various Types of Stabilizers

Jack bean tempeh was processed into jack bean tempeh milk. The addition of Ajwa date can improve the organoleptic and nutritional value of jack bean tempeh milk. Moreover, stabilizers must be added while making jack bean tempeh milk to enhance its quality. This study contributed to determining the effect of various stabilizers on jack bean tempeh milk quality. The treatments were (F1) the addition of iota carrageenan stabilizer (0.1%), (F2) the addition of gum Arabic stabilizer (0.1%), (F3) the addition of pectin stabilizer (0.1%), and (F4) the addition of carboxy methyl cellulose (CMC) stabilizer (0.1%). The results of this study showed that the stabilizer types had no significant effect on the organoleptic color, texture, and taste of the jack bean tempeh milk. The selected formulation was based on the hedonic quality test in the parameters of color and aroma, namely formula F4, which was jack bean tempeh milk with the addition of a CMC stabilizer. The results of the chemical characteristics of F4 jack bean tempeh milk was protein content of 0.65%, fat content of 2.48%, and antioxidant activity (IC50) of 7760 ppm. The physical characteristics of F4 jack bean tempeh milk was a pH value of 5.8, total dissolved solids of 20.7°Brix, a viscosity of 13.43 cP, L* value of 60.61, a* value of -0.12, and b* value of 19.56.

Grafting of voltage stabilizer onto EPDM surface and its inhibition effect on the breakdown of EPDM/XLPE interface

Surface discharge on the EPDM/XLPE interface is threatening the safe operation of power cable system and limiting the further improvement of its voltage level. To improve the electrical strength of EPDM/XLPE interface, the surface of EPDM was modified by grafting of voltage stabilizer 4-allyloxy-2-hydroxybenzophenone (AOHBP) based on liquid-phase impregnation and subsequent free radical grafting reaction thermally initiated by DCP. EPDM samples were modified by mixed reagents of DCP and AOHBP with different mass ratios of 1:2, 1:3 and 1:4, respectively. The SEM observation and XRD analysis results indicate that the crystals of AOHBP with a uniform distribution are covered on the surface of EPDM during the sample preparation process and then dissolved after extraction by acetone. The FTIR and ATR results show that the AOHBP molecules are successfully grafted onto the surface of EPDM samples, but there remain a lot of ungrafted reagent molecules on the surface of EPDM before solvent extraction. The grafting rate of AOHBP increases with the proportion of DCP in the mixed reagents. As for the unextracted modified EPDM samples, both the AC and DC breakdown voltage of the EPDM/XLPE interface are increased compared with pure EPDM, and further increased after the ungrafted molecules are extracted because the effect of voltage stabilizer on scavenging high-energy electrons is more efficiently utilized at a smoother interface. The interface breakdown voltage of the sample modified with 1:2 mass ratio of DCP/AOHBP mixed solution is the highest because of its highest grafting rate of voltage stabilizer. This work has proposed a new technical path to improve the electrical aging resistance of polymer insulating surface.

Feasibility of micro-organisms in soil bioremediation and dust control

Detrimental impacts of dust caused by mine tailings have yielded to several studies on the efficiency of different soil stabilizers. Bacterial stabilization has been recognized as a reality within recent decades, where bacteria could get adhesion to the grains and stabilize the soil particles. However, these bacteria are prone to be destroyed while exposed to the normal environmental conditions. In this study, the effects of microcapsules containing two types of bacterial freeze-dried spores (B.Subtilis Natto LMG 19457 and B.ESH) have been investigated on the mine tailing stability in terms of two parts. The first part of the study is dedicated to the fabrication of microcapsules within the two bacteria and identification of the characteristics of these microcapsules to set the time of microcapsules break and release in the soil. The urea-formaldehyde microcapsules containing tung oil were synthesized using microencapsulation method and at the following, the bacterial spores of B.Subtilis Natto LMG 19457 and B.ESH which had the high durability and the capability to grow in the silicon oil, were added to the microcapsules. The microcapsules effect on MT specimens and the viability of encapsulated spores were determined. The characteristics of the capsules were analyzed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and thermo-gravimetric thermal analysis (TGA). In the second part, wind tunnel tests were conducted to study the effects of microorganism stabilizers on mine tailings. The results indicated that the dust erosion reduced from 16% - using water as a stabilizer- to the 0.2% while using microcapsules containing B.Subtilis Natto LMG 19457 and 0.8% while using microcapsules containing ESH. The results showed the high efficiency of microcapsules containing bacteria in stabilizing the MTs. This phenomenon was proved by SEM imaging in which the voids were bounded significantly while using the bacteria.

Abstract 7221: A compound targeting the circadian clock protein CRY2 enhances therapeutic efficacy of bevacizumab in a colorectal cancer (CRC) xenograft model

Abstract Anti VEGF A antibody Bevacizumab combined with standard chemotherapy has improved outcomes for CRC patients. However, a subset of CRC patients acquires resistance to anti-VEGF treatment and underlying mechanism is poorly understood. Our recent study reported that circadian clock transcription factor BMAL1 drives transcription of VEGFA conferring resistance to bevacizumab treatment. Our rational is to stabilize negative regulator of circadian clock CRY protein to inhibit BMAL1 activity in a negative feedback loop. In this study, we evaluated whether CRY stabilizers SHP656 and SHP1705 in combination with bevacizumab can synergistically enhance anti-tumor effect in CRC mouse models. Methods: In vitro tube formation assay was performed with HUVECs cells to investigate the effect of CRY stabilizer on tube formation. For in vivo experiments, 106 HCT116 human CRC cells were injected subcutaneously into the right flank of 8-week-old nude mice. Mice (5mice/group) were randomized into: A. vehicle (2% carboxymethylcellulose PO 5 days/week; control IgG IP, 2 days/week); B. bevacizumab (5mg/kg IP, twice/week); C. 10mg/kg SHP656; D. 30mg/kg SHP656; E. 30mg/kg SHP1705; F. 10mg/kg SHP656 + bevacizumab; G. 30mg/kg SHP656 + bevacizumab; G. 30mg/kg SHP1705 + bevacizumab. SHP 656 &amp; 1705 was given PO; 5days/week. Tumor volume was measured three times a week. The survival curve was plotted using Kaplan and Meier method and assessed for statistical significance with log-rank test. Results: The in vitro tube formation assay showed significant inhibition of tube formation in HUVEC cells treated with SHP1705 plus bevacizumab compared to treated with bevacizumab alone. In in vivo study, the tumors treated with 30mg/kg SHP1705 + bevacizumab significantly suppressed tumor growth compared to bevacizumab monotherapy (one way-ANOVA, P &amp;lt;0.05). 30mg/kg SHP1705 + bevacizumab significantly improved survival of the mice (Log-rank test, P &amp;lt;0.05). No significant survival benefit was observed with bevacizumab alone. 3/5 mice treated with SHP1705 + bevacizumab showed decreased tumor volume and achieved complete regression for more than 4 months without additional treatment. In combination with bevacizumab, higher dose of SHP656 (30mg/kg) delayed tumor growth and extended survival compared with bevacizumab monotherapy (though did not reach statistical significance) whereas the lower dose of 10mg/kg did not show anti-tumor effect, demonstrating a dose dependent response. Conclusion: Our study shows that CRY stabilizers in combination with bevacizumab significantly enhances anti-tumor efficacy in CRC mouse models. Although mechanism of action of SHP compounds on angiogenesis pathway still needs further investigation, these findings may support development of novel treatment strategies modulating circadian clock to overcome bevacizumab resistance in CRC patients. Citation Format: Jae Ho Lo, Shivani Soni, Goar Smbatyan, Lesly Torres-Gonzalez, Pooja Mittal, Yan Yang, Francesca Battaglin, Priscilla Chan, Yuanzhong Pan, Sandra Algaze, Priya Jayachandran, Karam Ashouri, Alexandra Wong, Wu Zhang, Joshua Millstein, Indrakant K. Singh, Evanthia T. Roussos Torres, Shannon M. Mumenthaler, Steve A. Kay, Heinz-Josef Lenz. A compound targeting the circadian clock protein CRY2 enhances therapeutic efficacy of bevacizumab in a colorectal cancer (CRC) xenograft model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 7221.