Shear Effects Research Articles

REDUCING THE VISCOSITY OF THE OIL MIXTURE BY A ROTARY PULSE APPARATUS IN UKHTA — YAROSLAVL OIL PIPELINE

Physical methods of exposure can be used to improve the rheological characteristics of viscous, resinous oils, the transportation of which through main pipelines requires additional operating costs. The authors of this article evaluated the effectiveness of the method for improving oil rheology due to multifactorial effects (shear loads, high–amplitude pressure pulses, developed turbulence) on a sample of a mixture of oils of the Ukhta - Yaroslavl oil pipeline in a rotary pulse apparatus (RIA). The specific power consumption for processing an oil sample was 2.84 kWh/m3. The initial rheological and physico-chemical parameters of the studied oil are described, according to which it is characterized as heavy, viscous, highly resinous oil. The analysis of the flow curves showed that, by the nature of the flow, the sample of a mixture of oils from the Ukhta — Yaroslavl main oil pipeline belongs to Newtonian liquids. The evaluation of the effectiveness of the multifactorial effect on the oil sample implemented in RIA was carried out using dimensionless coefficients showing the ratio of dynamic viscosity, the specific power required to maintain the flow of oil in a rotary viscometer before and after physical exposure to oil, as well as the ratio of the change in the energy of thixotropy of oil to the energy spent on the processing process. The samples were processed in an RIA-based installation, in which pressure pulsations, developed turbulence, and large shear loads are generated in the liquid flow. When comparing the viscosity values of untreated and treated mixed oil in a rotary pulse apparatus, the dynamic viscosity measured at 20 °C decreased by 8 %. The component composition of the oil after processing in RIA has practically not changed. Measuring the viscosity of oil before processing and immediately after processing in RIA shows a decrease in viscosity by more than two times, since the temperature of the oil flow increases after passing through RIA by more than 10 °C. The increase in oil temperature during processing is due to large shear stresses during its flow in slit channels and in the gap between the rotor and stator due to the large amplitude of pressure pulsations and flow velocity.The relaxation time of the rheological parameters of the treated oil was seven days.

Simulation Analysis of the Annular Liquid Disturbance Induced by Gas Leakage from String Seals During Annular Pressure Relief

Due to the failure of string seals, gas can leak and result in the abnormal annulus pressure in gas wells, so it is necessary to relieve the pressure in gas wells. In the process of pressure relief, the leaked gas enters the annulus, causes a the great disturbance to the annulus flow field, and thus reduces the protection performance of the annular protection fluid in the string. In order to investigate the influence of gas leakage on the annular flow field, a VOF finite element model of the gas-liquid two-phase flow disturbed by gas leakage in a casing was established to simulate the transient flow field in the annular flow disturbed by gas leakage, and the influences of leakage pressure differences, leakage direction, and leakage time on annular flow field disturbance and wall shear force were analyzed. The analysis results showed that the larger leakage pressure difference corresponded to the faster diffusion rate of the leaked gas in the annulus, the faster the flushing rate of the leaked gas against the casing wall, and a larger shear force on the tubing wall was detrimental to the formation of the corrosion inhibitor film on the tubing wall and casing wall. Under the same conditions, the shear action on the outer wall of tubing in the leakage direction of 90° was stronger than that in the leakage directions of 135° and 45° and the diffusion range was also larger. With the increase in leakage time, leaked gas further moved upward in the annulus and the shear effect on the outer wall of tubing was gradually strengthened. The leaked acid gas flushed the outer wall of casing, thus increasing the peeling-off risk of the corrosion inhibitor film. The study results show that the disturbance law of gas leakage to annular protection fluid is clear, and it was suggested to reduce unnecessary pressure relief time in the annulus to ensure the safety and integrity of gas wells.

Shear stress effects on epididymal epithelial cell via primary cilia mechanosensory signaling.

Shear stress, resulting from fluid flow, is a fundamental mechanical stimulus affecting various cellular functions. The epididymis, essential for sperm maturation, offers a compelling model to study the effects of shear stress on cellular behavior. This organ undergoes extensive proliferation and differentiation until puberty, achieving full functionality as spermatozoa commence their post-testicular maturation. Although the mechanical tension exerted by testicular fluid is hypothesized to drive epithelial proliferation and differentiation, the precise mechanisms remain unclear. Here we assessed whether the responsiveness of the epididymal cells to shear stress depends on functional primary cilia by combining microfluidic strategies on immortalized epididymal cells, calcium signaling assays, and high-throughput gene expression analysis. We identified 97 genes overexpressed in response to shear stress, including early growth response (Egr) 2/3, cellular communication network factor (Ccn) 1/2, and Fos proto-oncogene (Fos). While shear stress triggered a rapid increase of intracellular Ca2+, this response was abrogated following the impairment of primary ciliogenesis through pharmacological and siRNA approaches. Overall, our findings provide valuable insights into how mechanical forces influence the development of the male reproductive system, a requisite to sperm maturation.

Computational Fluid Dynamics Analysis and Optimization of a Doublesuction Turbine Agitator

Background: As one of the essential pieces of chemical equipment, a reactor provides the necessary reaction space and conditions for the materials involved in the reaction during the stirring process. However, under typical operating conditions, issues such as uneven gas distribution, suboptimal gas-liquid mixing, and low product yield often arise in gas-liquid phase reactors. Purpose: To address the issues prevalent in current stirred reactors, a new design for a stirred reactor equipped with a double-suction turbine agitator was developed. Method: In this paper, a stirred reactor equipped with a double-suction turbine agitator was designed, and its three-dimensional modeling was conducted using SolidWorks. Computational Fluid Dynamics (CFD) simulations, based on the Euler-Euler two-phase approach with the RNG k −ε turbulence model, were performed to assess variables such as stirring speed, installation height, blade diameter and agitator inner diameter. The dispersion characteristics and flow field behaviors of the gas-liquid two-phase under varying conditions were comparatively analyzed. Optimizations were conducted across various parameters to enhance the gas mixing efficiency in the liquid phase. Result: The results show that a diameter of 370mm for the double-suction turbine agitator, an installation height of 640mm, a blade diameter of 500mm, and an inner hole diameter of 200mm yield optimal gas-liquid two-phase mixing performance. This configuration results in a broad and uniform gas distribution within the reactor, maintaining a desired high level of gas holdup at specific positions. Conclusion: The double suction turbine agitator is a type of radial agitator. During operation, it induces significant centrifugal forces in the liquid, exerts a robust shear effect, and enhances the mixing of the gas-liquid phases, thereby increasing the production efficiency of the product.

Stability and receptivity analyses of the heated flat-plate boundary layer with variable viscosity

This article presents the modal, non-modal, and resolvent analyses of the boundary layer developed over a heated flat-plate with temperature-dependent viscosity using linear stability theory. The governing equations are derived in the normal velocity–vorticity form by imposing small infinitesimal disturbances on the base flow with the Oberbeck-Boussinesq (OB) approximation. The spectral method is employed to discretize the governing stability equations in the wall-normal direction. The base flow comes from the similarity solution using R-K4th order method along with shooting techniques. The effects of viscosity stratification, inertia, shearing, and buoyancy on the stability of the boundary layer are investigated by varying the sensitivity parameter (ϵ), Reynolds (Re), Prandtl (Pr), and Richardson numbers (Ri). The modal analysis shows the time-asymptotic behavior of the disturbances and onset of instability is mainly caused by amplification of Tollmien–Schlichting (T-S) waves similar to as observe in the traditional Blasius case. The modal stability increases with increase in sensitivity parameter and stabilizing effects become more pronounced for liquid than gas. However, the thermal effects lead to destabilize the flow and strong destabilizing effects produced for higher Prandtl number. On the other hand, non-modal analysis displays an early transient growth of disturbances and an existence of these non-normality effects identified from the pseudospectra via. resolvent analysis. The non-modal growth increases with increase in ϵ even though T-S modes shift towards the damped region, which indicates the continuous modes in the eigenspectrum are more dominated than the discrete T-S modes due to the thermal effects. To clarify this qualitative change, a component-wise input–output analysis is performed to measure the receptivity to particular external disturbances. The results show the thermal energy of the disturbances is converted into kinetic energy due to thermal effects, resulting in strong receptivity amplification at the continuous mode due to the non-normality of the linear operator. Thus, the boundary layer under the influence of viscosity stratification, heating, and shearing effects is vulnerable to free-stream disturbances that could significantly affect bypass transition

Lateral Response Analysis of a Large‐Diameter Pile Under Combined Horizontal Dynamic and Axial Static Loads in Nonhomogeneous Soil

ABSTRACTThe large diameter piles are widely used in structures such as offshore wind turbines due to their superior lateral load‐bearing capacity. To explore the lateral response of a large‐diameter pile under combined horizontal dynamic and axial static loads in nonhomogeneous soil, a simplified analytical model of the pile–soil interaction is developed. This model represents the pile as a Timoshenko beam resting on the Pasternak foundation, incorporating the double‐shear effect by considering both pile and soil shear. The governing matrix equations for the pile elements are derived from the principle of virtual work. Further, the pile's lateral deformations and internal forces are obtained using the modified finite beam element method (FBEM) and then validated through existing analytical solutions. Finally, the contribution of various properties of pile, soil, and applied load to the pile's lateral vibration response are performed. It is found that both pile and soil shear effects significantly impact the lateral dynamic response of a large‐diameter pile. Additionally, in nonhomogeneous soil, decreasing surface soil strength and dimensionless frequency lead to increased lateral displacements and bending moments of the pile, which are significantly affected by the P‐Δ effect under increasing axial load.

Particle transport and turbulence modification in unstably stratified mixed convection within a horizontal channel

Particle transport and turbulence modification in an unstably stratified, particle-laden turbulent flow within a horizontal channel is studied via direct numerical simulations combined with Lagrangian point‒particle tracking techniques. Two-way coupling in momentum and energy is considered in dilute gas‒solid flows under mixed convection (synergistic effects of shear and buoyancy). For comparison, simulations of neutral turbulence are also conducted with equivalent parameters. The study reveals that large-scale longitudinal vortical structures induce significant spatial heterogeneity in the spanwise distribution of inertial particles. This heterogeneity is characterized by an increase in the particle concentration on the side of the cold plume and a corresponding decrease on the side of the hot plume. In the context of unstably stratified turbulence, particles reduce the fluid streamwise velocity and promote its profile toward symmetry. This phenomenon contrasts with that observed in neutral flows, where particles induce velocity asymmetry by dragging the upper flow and accelerating the lower flow. A quantitative analysis of the heat flux indicates that particles absorb heat as they settle, thereby reducing the average temperature of the flow. Buoyancy effects slow the settling and reinjection of particles, which in turn diminishes thermal energy absorption. Particles with higher inertia preferentially settle on the cooler plume side, minimizing their participation in heat exchange due to prolonged durations of repeated wall collisions.

Optimization of nanoscale heat transport analysis of ternary hybrid nanofluid over three‐dimensional wedge geometry in magnetized environment

AbstractExponential space‐based heat source with shear‐thinning/thickening behavior offers innovative insights into the optimization of thermal transport process in complex systems, such as in the cooling of microelectronics, energy storage technologies, and biomedical devices, where accurate thermal control is critical. This study explores the investigation of an exponential space‐based heat source with effects of shear thinning/thickening behavior of a ternary infinite shear rate viscosity‐dependent Carreau water‐based nanofluid [Cu, Fe3O4, SiO2] over a three‐dimensional wedge in a magnetized environment. The interaction between heat transport and magnetic fields is explored through the behavior of the ternary nanofluid by classifying the both shear‐thinning and shear‐thickening effects. The incorporation of physical assumptions in the model gives the set of partial differential equations (PDEs) and similarity transformations are launched to convert them into ordinary differential equations (ODEs). Furthermore, bvp4c scheme is used to fetch the numerical solution. Temperature profile is increasing with exponential‐based source heat parameter due to a reduction in the rate of heat absorption by the fluid. Ternary nanofluids exhibit the highest rate of temperature increment due to the effects of multiple nanoparticles as compared to hybrid or single‐nanoparticle nanofluids. Rate of velocity decrement in ternary nanofluids compared to bi‐hybrid nanofluids and single‐particle nanofluids.

Dynamic characterization of plasma and combustion wave interactions during millisecond-nanosecond combined laser-induced enhanced damage on fused silica

Fused silica, which is widely used in optical systems, limits the load capacity of the optical system when it is damaged by laser irradiation. In this paper, a combined millisecond-nanosecond pulsed laser induced triple combustion wave dynamics model for fused silica generation is developed. The relationship between pulse delay and the dynamic propagation of plasma and combustion waves induced by combined laser-induced fused silica was studied from three aspects: theory, simulation, and experiment. The results show that the energy deposition of the nanosecond laser injects energy into the dilute plasma, which increases the speed of the double-burning wave to form a triple-burning wave. In addition, it was found that the combined effect of viscous shear between the plasma plume and the air exacerbates the degree of imbalance in the Knudsen layer instantaneously releasing pressure and increasing the complexity of plasma and combustion wave propagation, recoil pressure produces a more complex crack network on the fused silica surface. The results provide a better understanding of the propagation properties of plasma and triple-burning waves during combined millisecond-nanosecond induced fused silica damage.

Effects of interaction between wheat bran dietary fiber and gluten protein on gluten protein aggregation behavior.

Effects of wheat bran dietary fiber (WBDF) as a nutritional additive on flour products quality mainly depends on the interaction between WBDF and gluten protein. In this study, the effects and mechanisms of WBDF with different particle sizes and additive amounts on gluten protein aggregation behavior were investigated. The results showed that the addition of WBDF led to a decrease in free sulfhydryl content, particle size, molecular weight and gluten macromer (GMP) content, an increase in zeta potential and SDS-extractable protein content, and a deterioration in the gluten network morphology compared to the control group, suggesting that the aggregation behavior of gluten protein was inhibited. When WBDF was added at 3 % and 6 %, dilution effect, mechanical shear, steric hindrance, and non-covalent binding were the main mechanisms leading to depolymerization. Further addition of WBDF (9 %, 12 %) inhibited the depolymerization of gluten protein due to competitive hydration and non-covalent binding. However, when WBDF was added at 15 %, the dilution effect, mechanical shear and steric hindrance of WBDF (88 μm < particle size<150 μm) dominated, and their inhibitory of aggregation induced the formation of a loose gluten network structure. In contrast, the weaker mechanical shear and steric hindrance effects of WBDF (particle size<88 μm) mitigated the degradation of gluten network structures by WBDF.

Shear-induced oil separation from a sand particle moving in water

Removing oil attached to fine solid particles in water purification presents challenging technical, economic, and ecological issues. The present work numerically investigates the shear effect on oil that contains a 100-μm-diameter sand particle in a water medium. In this research, we employ the coupled level set and volume of fluid method to track interface evolution accurately. An adaptive mesh refinement technique allows us to resolve an interface down to 60 nm. Computations at various particle Reynolds numbers (Rep=2−200) and oil film thicknesses (5%, 10%, 20%, and 40% of the diameter) reveal four coating behaviour scenarios: deformation, tail formation, partial separation, and full separation. The oil film negligibly deforms at Rep≤5 at most film thicknesses. The separation occurs in full or partial regimes at higher Rep and thicker films. A thinner film forms a tail that periodically fluctuates. The analysis shows that these fluctuations uniquely reshape the oil tail at each time period.

Numerical study of transition hydraulic jumps in different types of stilling basins using lattice Boltzmann methods

Transition hydraulic jumps, also known as low-Froude number jumps, have been less studied compared to high Froude number jumps, despite their significance in high-discharge and low-head dams. A three-dimensional (3D) Lattice Boltzmann method simulation was conducted to investigate submerged transition hydraulic jumps in both normal and expanded stilling basins, focusing on turbulent flow characteristics such as velocity fields, vorticity features, pressure fluctuations, and coherent structures. In expanded basins, two symmetric separated rollers were observed, with the rollers detaching from the submerged jump as the width of basin increased. The length of submerged roller in normal basins is observed as Lr/Ht = 6.19, while it is decreased to Lr/Ht = 4 in expanded basins because of the occurrence of roller lateral diffusion toward sidewalls. The transition of vortex structures from y- to z-vortical was analyzed, and three-dimensional shear layers are captured using the iso-surface of vorticity magnitude ω = 6.5. To further describe the internal structure of turbulence within the transition hydraulic jump, the coherent flow structures are qualitatively examined using the Ω criterion that is the third generation of vortex identification technique. Pressure fluctuations in low-Froude number stilling basins, described using root mean square (RMS), are first presented. High patches of RMS are found in the flow fields and at the bottom of basins, and it is qualitatively noted that shear effects make great contributions to the pressure fluctuations. Distribution of bottom pressure fluctuation RMS in different types of basin was also analyzed. The peak RMS value occurs at the ogee region of the weir, specifically at x/L = −0.2, and it is mainly affected by the width of expansion. Bottom pressure fluctuation RMS decreases in the following order: Normal, 5 m gradual expansion, 10 m gradual expansion, 5 m sudden expansion, and 10 m sudden expansion, due to the lateral diffusion of rollers toward sidewalls. This research introduces an innovative numerical simulation approach to studying pressure fluctuations, offering valuable insights for hydraulic engineering applications.

Study on the impact of grouting reinforcement on the mechanical behavior of non-penetrating fracture sandstone

The grouting reinforcement technology is an essential method to enhance the mechanical performance of fractured rock masses and the effectiveness of reinforcement varies with different grouting materials. To further understand the mechanical improvement capabilities of each grout and the reinforcement mechanisms at the grout-rock interface, this study prepared samples with different grouting materials (sulphoaluminate cement (SAC), ultra-fine cement (UFC), and epoxy resin (EPR)) and the uniaxial compression tests were conducted. Based on these tests, the macro and micro mechanical characteristics of different grouting samples were revealed using particle image velocimetry (PIV), acoustic emission (AE), scanning electron microscopy (SEM), and nuclear magnetic resonance (NMR). The results indicate that grouting helps improve the mechanical performance and deformation resistance of fractured rock masses. It effectively limited lateral displacement of the samples, reduced stress concentration at fracture tips, enhanced shear effects during sample fracture, and altered the crack propagation process and failure modes. Compared to the fractured samples, the peak strength of SAC, UFC, and EPR samples increased by 17.8 %, 23.4 %, and 28.3 %, and the elastic modulus increased by 14.3 %, 7.9 %, and 24.8 %, respectively. Among these, the EPR samples exhibited a similarity in parameter indicators to intact samples of over 85 %, making EPR the optimal grouting material. The degree of grout-rock fusion is the primary factor influencing grouting reinforcement effectiveness. SAC is covering-type cement, UFC is embedded cement, EPR is a fusion material, and the fusion-type materials are more beneficial for improving the mechanical performance of fractured rocks.

Study on seismic response of flexure-shear critical RC columns wrapped with TRC shells

Quasi-static tests were conducted on sixteen specimens to study the seismic response of flexure-shear columns wrapped with textile reinforced concrete (TRC) shells. Two RC square columns served as controls, while the remaining columns were wrapped with TRC shells. Three types of treatment methods were applied to TRC-wrapped columns herein to study the impact of different interfacial treatments on seismic behaviours. This study also analyzed the impacts of shear span ratios, axial load ratios, and number of textile layers on the seismic response of test columns. Results revealed that the TRC confinement layers could mitigate crack development, transforming RC columns' failure modes from flexure-shear to flexure. Due to greater confinement to the concrete core, TRC-wrapped columns exhibited enhanced performances compared to control columns, with peak loads, ductility, and cumulative energy dissipation increasing by up to 49.9%, 195.3%, and 5.7 times, respectively. TRC confinement layers could mitigate the shear effects in column specimens. TRC wrapping could improve the shear capacities of flexure-shear columns, with growth rates ranging from 25.2% to 60.4%. Eventually, an equivalent viscous damping model was proposed to assess the energy dissipation capacity of flexure-shear columns wrapped with TRC shells.

An evaluation of shear effect on the behavior of geometrically nonlinear structural system

An evaluation of shear effect on the behavior of geometrically nonlinear structural system

Regulating hardness homogeneity and corrosion resistance of Al-Zn-Mg-Cu alloy via ECAP combined with inter-pass aging

The novel processing strategies of Equal Channel Angular Pressing (ECAP) combined with inter-pass aging was designed, and XRD, SEM, TEM, electrochemical testing, and hardness testing were used to evaluate the relationship between microstructure and performance of alloys in this work. The results indicate that the hardness uniformity of the circular cross-section perpendicular to the extrusion direction was improved by combining ECAP with inter-pass aging, resulting in a hardness inhomogeneity factor (∼0.030) that was lower than that achieved by peak aging and double-stage aging alloys. Polarization curves and electrochemical impedance spectra show that a more negative corrosion potential and a smaller corrosion current density were possessed by the alloy, with the maximum intergranular corrosion depth (IGC) being reduced to 38 μm. Microstructure observation indicates that the improvement in hardness uniformity is due to the uniformity of grain size and the improved distribution and size of the η’ phase, which is attributed to the interaction between the pinning and shear effects of precipitates and dislocations during deformation. The enhanced corrosion resistance was attributed to an orderly combination of deformation and aging that increases the grain boundary volume and disrupts the η phase continuity within grain boundaries.

The combined effects of electrolyte addition and mechanical shearing on cellulose nanocrystal alignment

AbstractThis research explored the impact of four different electrolytes on the orientation of cellulose nanocrystals (CNCs) in shear-cast films prepared from aqueous CNC gels. Changes in the aqueous CNC gels’ rheological properties with electrolyte addition were correlated to the orientation and optical properties of dried CNC films. Film alignment was qualitatively assessed using cross-polarized optical microscopy and quantified by order parameters computed by UV–Vis transmission spectroscopy. Electrolyte addition resulted in an increased alignment in dried CNC films. For pure CNCs, the film order parameters remained constant at approximately 0.3 for shear rates from 20 s−1 to 100 s−1. However, higher order parameters were achieved in the presence of electrolytes. Notably, an order parameter of 0.88 was achieved at a shear rate of only 20 s−1. In addition, films produced from dispersions containing electrolytes exhibited improved clarity and haze. The results of this work highlight that electrolyte addition can enable higher order parameters at lower shear rates and facilitate the development of aligned CNC films for applications such as polarizers, clear coatings, and piezoelectric materials. Graphical abstract

A Green's Function Wind Turbine Induction Model That Incorporates Complex Inflow Conditions

ABSTRACTIn this work, we develop a new analytical turbine induction model that can incorporate complex inflow conditions including cases where the wind velocity and temperature profiles can vary as functions of height. This induction model is derived from the linearized Navier–Stokes and leads to a second‐order ODE that can be solved using a Green's function formulation. The corresponding Green's function for several configurations are found including the infinite domain, semi‐infinite domain with ground plane, and a power law velocity inflow profile. The results of this approach are then compared with simulations of the turbine induction field using the AMR‐Wind CFD solver with a uniformly loaded actuator disk model. These comparisons show that the Green's function approach captures the centerline blockage, three‐dimensional blockage flow field, and streamwise velocity slow down, with very good agreement for lower thrust conditions and at larger distances away from rotor disk. The effects of shear on the turbine blockage were also compared using a power law inflow profile, and we show that this approach matches the CFD predictions for the cases considered.

Viscous shear is a key force in Drosophila ventral furrow morphogenesis.

Ventral furrow (VF) formation in Drosophila melanogaster is an important model of epithelial folding. Previous models of VF formation require cell volume conservation to convert apically localized constriction forces into lateral cell elongation and tissue folding. Here, we investigated embryonic morphogenesis in anillin knockdown (scra RNAi) embryos, where basal cell membranes fail to form and therefore cells can lose cytoplasmic volume through their basal side. Surprisingly, the mesoderm elongation and subsequent folding that comprise VF formation occurred essentially normally. We hypothesized that the effects of viscous shear may be sufficient to drive membrane elongation, providing effective volume conservation, and thus driving tissue folding. Since this hypothesis may not be possible to test experimentally, we turned to a computational approach. To test whether viscous shear is a dominant force for morphogenesis in vivo, we developed a 3D computational model incorporating both accurate cell and tissue geometry and experimentally measured material parameters. Results from this model demonstrate that viscous shear generates sufficient force to drive cell elongation and tissue folding in vivo.

Shear-Sensing by C-Reactive Protein: Linking Aortic Stenosis and Inflammation.

CRP (C-reactive protein) is a prototypical acute phase reactant. Upon dissociation of the pentameric isoform (pCRP [pentameric CRP]) into its monomeric subunits (mCRP [monomeric CRP]), it exhibits prothrombotic and proinflammatory activity. Pathophysiological shear rates as observed in aortic valve stenosis (AS) can influence protein conformation and function as observed with vWF (von Willebrand factor). Given the proinflammatory function of dissociated CRP and the important role of inflammation in the pathogenesis of AS, we investigated whether shear stress can modify CRP conformation and induce inflammatory effects relevant to AS. To determine the effects of pathological shear rates on the function of human CRP, pCRP was subjected to pathophysiologically relevant shear rates and analyzed using biophysical and biochemical methods. To investigate the effect of shear on CRP conformation in vivo, we used a mouse model of arterial stenosis. Levels of mCRP and pCRP were measured in patients with severe AS pre- and post-transcatheter aortic valve implantation, and the presence of CRP was investigated on excised valves from patients undergoing aortic valve replacement surgery for severe AS. Microfluidic models of AS were then used to recapitulate the shear rates of patients with AS and to investigate this shear-dependent dissociation of pCRP and its inflammatory function. Exposed to high shear rates, pCRP dissociates into its proinflammatory monomers (mCRP) and aggregates into large particles. Our in vitro findings were further confirmed in a mouse carotid artery stenosis model, where the administration of human pCRP led to the deposition of mCRP poststenosis. Patients undergoing transcatheter aortic valve implantation demonstrated significantly higher mCRP bound to circulating microvesicles pre-transcatheter aortic valve implantation compared with post-transcatheter aortic valve implantation. Excised human stenotic aortic valves display mCRP deposition. pCRP dissociated in a microfluidic model of AS and induces endothelial cell activation as measured by increased ICAM-1 and P-selectin expression. mCRP also induces platelet activation and TGF-β (transforming growth factor beta) expression on platelets. We identify a novel mechanism of shear-induced pCRP dissociation, which results in the activation of cells central to the development of AS. This novel mechanosensing mechanism of pCRP dissociation to mCRP is likely also relevant to other pathologies involving increased shear rates, such as in atherosclerotic and injured arteries.