: Dental caries is a major public health concern commonly affecting all age groups. Early detection and treatment of such lesions will limit the need for invasive treatment in the future. Resin infiltration is proposed as an encouraging non-invasive approach that can be used as an option in addition to non-operative and operative approaches to treatment.: To assesses the efficacy of micro-invasive interventions (resin infiltration or sealing) for controlling caries progression on proximal surfaces.The randomized clinical trial was carried out among 30 proximal caries lesion patients. After randomization participants were equally allocated in three groups; infiltration, sealant and placebo. DMFT & DMFS index and ICDAS were recorded at baseline, 3 months, 6months and 9 months. The ANOVA and chi square tests were used to determine significant differences between groups. In all tests, p-values less than 0.05 were considered significant. : There is a significant difference in the mean DMFT and DMFS value of infiltration and resin group as compared to control group p value 0.023 and 0.007 respectively. Also infiltration group had lower score as compared to resin group. Also, Infiltration group had the lowest mean ICDAS score at all time points, indicating the lowest severity of tooth decay, followed by the sealant group and then the Control group. : Our randomized controlled trial provides valuable insights into the effectiveness of resin infiltration, sealant, and placebo groups in preventing the progression of early enamel lesions. Resin infiltration was found to be the most effective method.
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