Effect Of Prostaglandin Administration Research Articles

Effects of prostaglandin administration after farrowing on milk output, vaginal discharge, and mastitis during the early postpartum period in sows under field conditions

Effects of prostaglandin administration after farrowing on milk output, vaginal discharge, and mastitis during the early postpartum period in sows under field conditions

1056 WS Effect of prostaglandin administration after ram exposure on ewe reproductive efficiency

1056 WS Effect of prostaglandin administration after ram exposure on ewe reproductive efficiency

Anöstrus Dönemindeki Multipar ve Nullipar Koyunlarda Koç Etkisi ve Prostaglandin Uygulamalarının Dölverimi Üzerine Kombine Etkisi

Anöstrus Dönemindeki Multipar ve Nullipar Koyunlarda Koç Etkisi ve Prostaglandin Uygulamalarının Dölverimi Üzerine Kombine Etkisi

Effect of prostaglandin administration during the first hours after calving on blood calcium concentration in multiparous dairy cows

Subclinical hypocalcemia is a common metabolic disorder of dairy cows after parturition. The administration of prostaglandin (PGF2a) results in improvement of uterine health in some experiments, which may be explained by the effect of PGF2a on calcium and vitamin D metabolism.

Effect of Prostaglandins for Inducing Birth on Weight, Vitality and Physiological Response in Newborn Pigs

Sánchez-Aparicio, P., Mota-Rojas, D., Trujillo-Ortega, M.E., Zarco-Quintero, L.A., Becerril-Herrera, M., Alonso-Spilsbury, M. and Alfaro-Rodríguez. A. 2008. Effect of prostaglandins for inducing birth on weight, vitality and physiological response in newborn pigs. J. Appl. Anim. Res., 36: 113–118. To evaluate the effect of prostaglandin administration to induce farrowing on incidence of stillbirth (SBP), evidence of intra-partum hypoxia (HBP) and weight, viability and acid-base equilibrium in piglets at birth, 395 newborns product of 40 Yorksh1ire × Landrace hybrid were studied upon. Sows were randomly divided equally into two treatments. Treatment 1 (T1) received 2 ml of an intramuscular (IM) normal saline solution and Treatment 2 (T2) was treated with a single dose of 10 mg IM of prostaglandin analogue, to induce a synchronized parturition 48 h before the estimated time of parturition. The weight of the SBP was approximately 142 g less (P<0.0376) in T2 (PGF2α, compared with the T1. The weight of the HBP was approximately 247 g less (P<0.0001) in T2 compared to T1. The vitality score of ABP was good in both treatments. Two response variables (glucose, Ca++) in ABP were significantly greater in T2 compared to T1. When PGF2α was injected in the sow 48 h before giving birth, it has negative effects causing hyperglycemia and low weight at birth and diminished vigor in the newborn piglets. However, further studies with variable time interval are recommended.

Maternal plasma corticotropin-releasing factor (CRF) and CRF-binding protein (CRF-BP) levels in post-term pregnancy: effect of prostaglandin administration

Placental corticotropin-releasing factor (CRF) affects myometrial contractility and the secretion of several uterotonins such as prostaglandins (PGs); however, the activity of CRF is counteracted by CRF-binding protein (CRF-BP). At term and pre-term labor, CRF levels in maternal plasma are highest whereas those of CRF-BP are falling, and the cause of this fall is unknown. Thus, in this study, we investigated the effect of PG administration for labor induction on maternal plasma CRF and CRF-BP concentrations. Maternal plasma CRF and CRF-BP levels were assayed before and after (2 h later) induction of labor by intracervical administration of prostaglandin E(2) (PGE(2)), and at delivery in a group of healthy post-term pregnancies (n=18). Controls were women at term out of labor (n=22), who subsequently progressed to deliver a healthy singleton baby. CRF was measured by two-site immunoradiometric assay, and CRF-BP was assayed by radioimmunoassay. Maternal plasma CRF levels were significantly (P<0.0001) lower and CRF-BP significantly (P<0.0005) higher in post-term than in term pregnancies. With respect to induction of labor, 2 mg PGE(2) were sufficient to increase maternal plasma CRF levels at delivery (P<0.005). While 0.5 mg PGE(2) significantly decreased maternal plasma CRF-BP levels at delivery (P<0.001), 2.0 mg PGE(2) significantly reduced CRF-BP concentrations both after 2 h (P<0.05) and at delivery (P<0.0001). In the light of the well-known stimulation of prostaglandin release by CRF, these data suggest a positive feedback effect of PGE(2) on maternal CRF release during induced labor.

The effect of prostaglandin administration to Holstein-Friesian cows at Day 26 postpartum on clinical findings, and histological and bacteriological results of endometrial biopsies at Day 40

Ninety-two cows that calved between April and August 1984 in a commercial dairy herd were studied. The cows were randomly assigned to receive either cloprostenol (500 mug) or saline placebo on Day 26 postpartum. In addition, each cow was examined per rectum, had three endometrial biopsies taken and milk progesterone level determined. Double-blind techniques were used in administering treatments and in assessing response to treatment. The results of histological and bacteriological assessment of endometrial biopsies and clinical findings at Day 40 were compared between the cows that received prostaglandin at Day 26 and those that did not. Each Day 40 variable which was significantly associated with prostaglandin treatment at Day 26 was regressed against the treatment variable and progesterone level at Day 26 as well as a prostaglandin progesterone interaction term. Prostaglandin-treated cows had less vaginal discharge, smaller diameter uterine horns, less inflammation and fibrosis in the endometrium, and were less likely to have Actinomyces pyogenes isolated from a biopsy at Day 40 than untreated cows. These effects were independent of progesterone level at the time of treatment.

Effect of indomethacin on blood plasma levels of LH and testosterone in male rats.

Treatment of adult male rats with indomethacin, an inhibitor of prostaglandin (PG) synthesis, caused a significant decrease in LH and testosterone levels in the blood plasma and in the weight of the seminal vesicles, but the weight of the testes and ventral prostate, the levels of FSH in the plasma and fertility were not affected. The concentration of PGF in the blood plasma of the treated animals was reduced, even though measurable amounts of PGs were present in every group. The results of this study, together with the known effects of PG administration on LH release, suggest that the reduction of plasma LH levels in rats injected with indomethacin was due to decreased PG synthesis. It appears that PGs are normally involved in the regulation of LH release.