Objective: To investigate the effect of an antioxidant, palm vitamin E (Tri-E) on fetal growth and birth weight. Methods: This randomized double blind placebo-controlled clinical trial involved 113 primigravidae seen at the Antenatal Clinic of Hospital UKM. Supplementation of Tri-E (100 mg daily) was given from 12 to 16 weeks’ gestation onwards until delivery of the baby. Ultrasound measurement of fetal biometry was performed every four weeks from 20 weeks onwards. The head over abdominal circumference ratio (HA ratio) was calculated to indicate the fetal growth from 28 weeks’ gestation onwards. At delivery, birth weight was recorded. Statistical test using the independent samples t-test was performed for analysis. Results: Out of 113, 46 were in the study group and 67 were in the placebo group. There were no statistically significant differences in the HA ratio between the two groups at 32 weeks (mean 1.04 for study and mean 1.05 for placebo) and 36 weeks’ gestation (mean 1.00 for study; mean 1.01 for placebo) respectively. As for the birth weight, there were also no statistically significant differences between the study (mean birth weight: 2992 grams) and placebo group (mean birth weight: 3267 grams). Conclusion: Early supplementation with Tri-E starting from the first trimester did not result in acceleration of fetal growth and delivery of bigger babies at birth.