Nurses face not only musculoskeletal disorders but also psychological health issues. The purpose of this study is to analyze the factors influencing overall fatigue, anxiety, and depression, respectively, by comprehensively considering work characteristics, exposure to hazards, and the presence of musculoskeletal pain. This study used binary logistic regression to analyze factors influencing fatigue, anxiety, and depression, respectively. The independent variables were occupation; age; work experience; healthcare organization; working hours per week; shift type; exposure time to physical, biochemical, and ergonomic hazards; and the presence of back, upper limb, or lower limb pain. The factors influencing overall fatigue were shift type (p = 0.007), exposure to vibration (p = 0.042), awkward posture (p = 0.001), repetitive motion (p = 0.017), and presence of back (p = 0.002) or upper (p < 0.001) limb pain. The factors influencing anxiety were age (p = 0.031), hours worked per week (p = 0.006), performing patient lifting/carrying (p = 0.041), and presence of upper (p = 0.022) or lower (p = 0.039) limb pain. In addition, the factors influencing depression were found to be hours worked per week (p = 0.042), exposure to infection (p = 0.005), and the presence of lower limb pain (p = 0.011). This study found that musculoskeletal pain has a significant impact on psychological health problems, suggesting that integrated management of musculoskeletal pain and psychological health problems may be effective in addressing health problems in the nursing profession.
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