Heat transfer analysis of Casson nanofluid flow with single and multi-walled carbon nanotubes and Al2O3 or GO nanoparticles, which are suspended in kerosene oil, is elucidated. The impact of second slip conditions on the flow system’s velocity, temperature, and solutal is considered, along with the effect of melting heat transfer and nanoparticle shape factor. The appraisal’s novelty is the incorporation of second slip conditions on kerosene oil flow containing with new three distinct nanoparticles. Similar variables are used to convert the governing equations into ordinary equations which are then solved using homotopy perturbation method (HPM). The profiles of velocity, temperature, concentration, and Bejan number are estimated for various values of relevant parameters. Results demonstrate that the Bejan number declines due to enhance the first thermal parameter and second velocity parameter, while the contrary tendency is examined by raising the Casson fluid parameter and first velocity parameter. Al2O3-SWCNT-MWCNT TNF responds more strongly than GO-SWCNT-MWCNT TNF when the temperature is coupled with (nanoparticles volume fraction, first thermal parameter), axial velocity with (nanoparticles volume fraction, first velocity parameter, first thermal parameter), and Bejan number with melting parameter. This study is to help rocket engine designers identify the optimal nanofluids for cooling and fuel.