Effect Of Mangosteen Peel Extract Research Articles

The Effect of Mangosteen Peel Extract (Garcia Mangostana L) and Shelf Life on the Physical Quality of Chicken Eggs

The Effect of Mangosteen Peel Extract (Garcia Mangostana L) and Shelf Life on the Physical Quality of Chicken Eggs

Pengaruh Pemberian Ekstrak Kulit Manggis pada Tikus Tuberkulosis yang Diberi Isoniazid terhadap Kadar Kolesterol


 
 
 
 
 
 
 
 
 
 
 
 
 Patients with tubeculosis experience a decrease in the amount of cholesterol in the body due to an inflammatory process due to increased free radical formation due to oxidative stress arising as a result of increased phagocytic activity of monocytes and macrophages. Therefore, additional treatment is needed to overcome free radicals and ROS so that inflammation in TB patients does not get worse and cholesterol levels can return to normal. Treatment of isoniazid in TB patients can increase cholesterol levels but does not occur significantly, and the results are still lower than cholesterol levels in healthy individuals. Mangosteen peel extract has a variety of ingredients and one of them is xanthones which can be anti-inflammatory and can inhibit the increase in the formation of free radicals in TB patients. The main objective of this study was to determine the effect of mangosteen peel extract on TB rats given isoniazid on cholesterol levels. This research is a laboratory experimental study with a randomized posttest only method. The research sample used by the previous researcher, Dr. dr. Indah Widyaningsih., M. Kes was the blood serum of white rats (Rattus Norvegicus) aged 2-3 months with a body weight of 200-250 grams. The analytical test used in this study is the Kruskall-Wallis test. The results of the analysis that has been done by researchers, it is known that there is no effect of Mangosteen Skin Extract on Cholesterol Levels in TB rats given Isoniazid
 
 
 
 
 
 
 
 
 
 
 
 

Giving Various Concentrations of Mangosteen Peel Extract by Spraying Method to Rice Quality in Perum Bulog, Cianjur Regional Subdivision

As the main food commodity in Indonesia, the quality of rice is an important thing that must be considered, including postharvest handling during storage. Improper storage conditions can trigger pest and microbial contamination which has the potential to accelerate rice quality degradation during storage. Mangosteen peel is rich in antimicrobial and antifungal compounds, but their use is still limited. This study aims to determine the effect of mangosteen peel extract at concentrations of 2.5%, 5%, and 7.5% on the quality of rice in the medium class category for 30 days of storage at the Cianjur regional sub-division BULOG warehouse. The results show that the decline in the quality of rice including moisture content, broken kernel, chips, yellow kernel and the presence of pests could not be slowed down by administering mangosteen peel extract. Until the end of the storage period, Ahasverus advena was the most commonly found pest. The percentage of water content, broken grains, groats, and yellow grains in rice at the end of storage in all treatments can still be categorized into the medium class according to SNI with an average value of respectively 12.53%, 13.36 %, 4.02%, and 1.27%.

Effect of mangosteen peel extract on BPA-exposed murine during gestation

Aim: To evaluate the potential protective effects of mangosteen peel extract against BPA-induced abnormalities on-pregnant mice fetus at implantation stage and offspring at post-parturition. Methodology: Pregnant mice were orally administered with BPA (100mg kg-1 b.wt.) and mangosteen peel extract (200mg kg-1 b.wt.) for 16 days. In order to evaluate the effect of MPE treatment on fetus at implantation stage, the pregnant mice were euthanized at day 18 and the fetus number and morphology were examined. Another group of treated dams, were allowed to undergo parturition for evaluating the of maternal weight, litter size and offspring sex-skewness. Results: Upon feeding Mangosteen peel extract (MPE), the average daily weight gain of dams were not significantly different from the control and BPA treated dams. The fetus derived from BPA treated dams were detected with abnormalities such as under development, haemorrhage and absence of vein, whereas fetus from dam treated with MPE and BPA as well as control were normal. The average litter size of all the treatment groups were not significantly different from the control group. BPA treated mice had lower pups survival up to 6 weeks compared to the groups treated with MPE and control. Test of proportion analysis showed BPA-treated group had significantly higher fraction female ratio. Interpretation: BPA is known as endocrine disruptor causing oxidative stress to female reproductive system, hence mangosteen peel extract contains antioxidant substances that have the potential to ameliorate the adverse effects of BPA exposure on dams during pregnancy and its fetus development.

Effect of Mangosteen Peel Extract (Garcinia mangostana l.) with Supplemental Zinc and Copper on Performance and Egg Quality of Sentul Laying Chicken

Effect of Mangosteen Peel Extract (Garcinia mangostana l.) with Supplemental Zinc and Copper on Performance and Egg Quality of Sentul Laying Chicken

The Changes of Mice Reproductive Hormones (Mus musculus) Caused by Mangosteen (Garcinia mangostana L.) Skin Extract

Background. The population in Indonesia has been increasing from 2016 to 2018 and will continue to increase in 2019. The efforts of the Indonesian government to reduce the rate of population growth by establishing a family planning program for couples of childbearing age with the most widely used methods are injections and pills. However, the acceptor of birth control pills risk 17.2 times to cause hypertension, so it is necessary to develop alternative contraceptives. Mangosteen peel extract contains compounds that can inhibit the fertilization process. Objective. This study aims to determine the effect of mangosteen peel extract on the process of folliculogenesis in female mice. Methods. This study is a true experimental study with a post-test only - control group design. Mice were divided into five groups, the negative control group; a positive control group was mice given the combined contraceptive pill; group treated with three different doses of group, P1 was given mangosteen peel extract 9.8 mg / day; P2 was given mangosteen peel extract 19.6 mg / day; P3 was given mangosteen peel extract 39.2 mg / day for 21 days. Each group consists of 6 mice. Results: This study shows that giving mangosteen peel extract at a dose of 9.8; 19.6 and 39.2 mg / 20 gBB had no effect on Luitenizing Hormone levels estradiol levels, progesterone levels (ρ = 0.172, 0.195, 0.260). Conclusion: It can be conclude that mangosteen peel extract had no effect on reproductive hormones.

Pengaruh Pemberian Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) Menghambat Flexi Cranial Embrio Ayam Umur 48 Jam

Embryonic development forms three layers of germinativum that is endoderm, mesoderm and ectoderm. At the beginning of intrauterine fetus exchange of substances through diffusion, but in line with the development of the embryo, nutrition is not obtained through diffusion alone. Endoderm lining mesoderm cells will then be formed angioblasts as an early sign of vascularity. In the development of flexi cranial can be known from the development of the brain and heart which is characterized by bending the head of the embryo and decreased heart from the cranial down. The development of a normal vascular system will have an effect on organogenesis and morphogesis processes. If there are disturbances in the process of growth and development at that stage can cause congenital abnormalities. Xanthones mangosteen peel is rich in benefits, but in research on the effects of xanthones on embryos is still very limited and has not been able to explain their effects on the condition of the fetus. The study was conducted with the aim to determine the effect of mangosteen peel extract inhibiting the flexi cranial of 48 hours chicken embryos using doses of 100 µg/mL, 150 µg/mL and 200 µg/mL. Mangosteen peel extract is injected into chicken eggs less than 7 days after oviposition then incubated for 48 hours. The results showed that mangosteen peel extract inhibited flexi cranial of chicken embryos with Chi-Square test results (p = 0.002). The conclusion of the study was that exposure to mangosteen peel extract inhibited flexi cranial and gave significant results.

Application of Mangosteen Peel Extract (Garcinia mangostana L) As Feed Additive in Ration for Performance production and Egg Quality of Sentul Chicken

Sentul chicken is a specific local chicken from the Ciamis region in West Java and a dual-purpose type that can be utilized for eggs and meat production. The use of antibiotics continuously for maintenance to prevent and treat disease in Sentul chicken can lead residues in meat and eggs. To wean farmers for the antibiotic, it is necessary to find a natural antibiotic derived from herbal plants that Mangosteen Peel Extract (MPE). Mangosteen Peel Extract (MPE) is containing xanthone compounds like antioxidants and antimicrobials. This research was held to find out the effect of mangosteen peel extract on feed consumption, hen day production, feed conversion, and egg quality. This research used 40 female chickens aged seven months, which was kept in cages until three months, and each cage contains 2 chickens. The method used was a completely randomized design with four treatments namely P0 (ration without MPE), P1 (ration with 67 ml/kg MPE addition), P2 (addition of 100 ml/kg MPE) and P3 (addition of 133 ml/kg MPE) with five replications. Furthermore, treatment differences were tested using Duncan Multiple Range Test. The measured variables were feed consumption, egg weight, hen day production, feed conversion, thick of shell, egg yolk color, and egg cholesterol. The results showed the addition of MPE 133 ml/kg ration had a significant effect on egg production, egg weight, feed conversion, the thickness of eggshell, the color of egg yolk, and egg cholesterol but not significant to feed consumption, yolk index score and Haugh unit. It can be concluded that MPE can be used as a feed additive until 133 ml/kg ration to gave the best on production and egg quality of Sentul chicken.

Effect of mangosteen (Garcinia mangostana L.) peel extract as an antibiotic growth promoter on growth performance and antibiotic resistance in broilers.

Background and Aim:Antibiotic resistance poses a risk to human health and has therefore been the focus of research. One of the causes of this resistance is the use of antibiotics as feed additives for animal nutrition. The development of antibiotic resistance in poultry through nutrition feed has drawn attention to the need for alternative antibiotic growth promoters (AGPs). Mangosteen (Garcinia mangostana L.), as a natural source of bioactive phytochemicals, is a potential AGP, but the effect of mangosteen-based treatment on antibiotic resistance in poultry has not been reported to date. Therefore, the aim of this study was to evaluate the effects of mangosteen peel extract as an AGP on body weight gain, feed conversion rate (FCR), and the antibiotic resistance in broilers.Materials and Methods:In this study, 30 1-day-old broiler chicks were divided into three groups. Group A (control) was not administered any treatment in the feed, Group B was treated with 0.3 g/kg colistin as the AGP in the feed, and Group C was treated with 2% mangosteen peel extract as the AGP in the feed; the treatments were administered for 30 days. The observed parameters included the effect of the treatments on body weight gain, feed intake, FCR, and the presentation of antibiotic resistance before and after the treatments (pre-treatment and post-treatment, respectively).Results:Post-treatment, the body weight gain, and feed intake in the broilers were not significantly different among all the groups; however, the body weight gain and FCR were significantly different between the control group and the treatment groups in the 3rd week of treatment and were not significantly different between Groups B and C. The rate of antibiotic resistance to chloramphenicol increased significantly by 40% in Group B post-treatment, but no such increase was observed in Groups A and C.Conclusion:The findings of our study indicate that compared with using colistin as an AGP using mangosteen peel extract as a natural AGP did not have any significantly different effect on body weight gain, feed intake, and FCR (p>0.05) but had a significantly different effect on the rate of antibiotic resistance in broilers (p<0.05). This study indicates the usefulness of mangosteen for improving the overall growth and production performance of broilers without increasing their antibiotic resistance.

PENGARUH EKSTRAK KULIT BUAH MANGGIS (Garcinia Mangostana Linn) TERHADAP PERISTALTIK ILEUM TERPISAH MARMOT JANTAN SEBAGAI ANTI DIARE

Objective: to determine the effect of mangosteen peel extract (Garcinia mangostana Linn) on ileal peristalsis separate male guinea pigs as diarrhea. Results: t-independent test, the difference: Contraction of ileum Acethlcholin with Atropine + Acethylcholin is 6.333 compared to Acethylcholin with extract + Acethylcholin is 8,500 with ANOVA test P value meaning the difference between the two contractions of the ileum is significant. The t-independent test results are the difference: Contraction of ileum Histamine with Diphenhidramine + Histamine is 8.333 compared to Histamine with extract + Histamine is 10.833 with ANOVA test P value meaning the difference between the two contractions of the ileum is significant. The results of the t-independent test are the difference: Contraction of the Barrium ileum with Papaverine + Barrium is 2,500 compared to the contraction of Barrium ileum with extract + Barrium is 2,500 with ANOVA test P value meaning that there is no difference between the two contractions of the ileum. From the three experimental groups, it was concluded that the extract worked similar to Papaverine. Cecilia's study, fruit skin extract can be used as diarrhea in Diare Effect of Mangosteen Ethanol Extract of Oleum ricini-induced Webster Swiss Mice.

Effect of Mangosteen Peel Extract on SGOT and SGPT in Rats Fed Reused Cooking Oil

Background: Free radicals that enter the body due to consumption of reused cooking oil can cause liver cell damage. Mangosteen peel extract (Garcinia mangostana L) is known to contain mangostin as an ntioxidant. However, it is not known whether it can repair liver damage.Objective: To deter mine the ef fect of mangosteen peel extract on the levels of SGOT and SGPT of Wistar rats fed with reused cooking oil.the ef fect of mangosteen peel extract on the levels of SGOT and SGPT of Wistar rats fed with reused cooking oil.Methods: This study was a tr ue experimental study with post-test only controlled group design. Twenty four male Wistar rats were randomly divided into 4 groups randomly. The CN-G group was given the standard diet, the MJ-G group was given a standard diet and cooking oil, the MJM- 400 group was given standard diet, reused cooking oil, and mangosteen peel extract at a dose of 400 mg/KgBW, and the MJM-800 group was fed with a standard, reused cooking oil, and mangosteen peel extract at 800mg/KgBW. The treatment was car ried out for 28 days, and then continued with examination of reused cooking oil, and mangosteen peel extract at 800mg/KgBW. The treatment was car ried out for 28 days, and then continued with examination of SGOT and SGPT levels using the Inter national Federation of Clinical Chemistr y (IFCC) method without Pyridoxal Phosphate 37ºC.Results: Kr uskal Walis test showed that SGOT and SGPT levels showed no signif icant dif ferences between groups (p = 0.197 and 0.063, respectively).Conclusion: administration of mangosteen (Garcinia mangostana L) peel extract did not af fect SGOT levels, even tended to increase SGPT levels in ratsinduced by cooking oil.

Effects of Mangosteen Peel Extract (Garcinia Mangostana L.) on Blood Lipid of Sentul Chicken Growth Phase

Nutrition has been reported to have a huge role in maintaining the lipid in the blood. Xanthone is a very powerful antioxidant which can reduce the lipid in the blood. Xanthones, terpenoids and sugars have been reported can be found in the different parts (pericarp, whole fruit, bark, and leaves) of mangosteen and some of them have shown a variety of biological activities. Therefore, a study was conducted to evaluate the effect of mangosteen peel extract (Garcinia mangostana L.) on blood triglyceride and glucose of Sentul chicken growth phase. A total of 100 Sentul chickens (10 weeks old) were used in this study. The research used an experimental method with a completely randomized design (CRD). The chickens were randomly assigned into four treatment groups of P0, P1, P2 and P3, replicated 5 times of 5 chickens each. The blood taken at the end of experiment. The chickens in the first group (P0) were given basal feed without mangosteen peel extract, while P1, adding with 41 mL/kg ration; P2 = 81 mL/kg ration, and P3 = 122 mL/kg ration. There was a significant (p<0.05) reduction in triglyceride blood level of Sentul Chicken compared to without supplementation, and highest reduction in group fed P3. The blood glucose was non-significant difference. Addition of mangosteen extract peel in diet of Sentul chicken had beneficial effect in reducing the blood triglyceride and the level of blood glucose is almost the same.

Effect of mangosteen peel extract as an antioxidant agent on the shear bond strength of orthodontic brackets bonded to bleached teeth.

Introduction: The number of patients who seek orthodontic treatment that may have a history of tooth bleaching is increasing over the time. Bleaching may influence the decrease of the bond strength of orthodontic brackets. Objective: To determine and prove the effect of mangosteen peel (MP) extract to reverse the reduced shear bond strength (SBS) of orthodontic brackets after bleaching. Methods: A total of 150 maxillary first premolar teeth were randomly divided into 6 experimental groups as follow (n=25): negative-control (N: no bleaching), positive-control (P: bleaching + no treatment), and the treatment groups (bleaching + 10% sodium ascorbate (SA), 10% (MP-10), 20% (MP-20) and 40% (MP-40) MP extract gel). After treatment, the brackets were bonded with the resin-modified glass ionomer cement, SBS testing was performed using universal testing machine, and the adhesive remnant index (ARI) was examined using stereoscopic microscope after debonding. The SBS data were analyzed by analysis of variance (Anova) and the Tukey test. For the ARI, the Kruskal-Wallis test was performed. Result:There was significant SBS difference (p< 0.001) between various groups. The group without bleaching showed significantly higher SBS (8.19 ± 2.26 MPa) compared to others, while SBS in the group treated with 40% MP gel was significantly higher (7.93 ± 1.92 MPa) than other groups treated with antioxidants. The failure of orthodontic brackets bonded after bleaching and treatment using MP extract occurred at the enamel-adhesive interface. Conclusion: The application of MP extract as an antioxidant after bleaching was effective in reversing the reduced shear bond strength of orthodontic brackets after bleaching.

Effect of Mangosteen Skin Extract (Garcinia mangostana L.) on Males Mice (Mus musculus L. Swiss Webster) Uric Acid Level

Uric acid (gout) caused by high levels of uric acid in the blood (hyperuricemia). Inflammation caused by uric acid crystals cause pain, stiffness, and swelling in the joints. Gout medication allopurinol commonly consumed ie the mechanism of action as an inhibitor of xanthine oxidase, but this drug side effects such as nausea and diarrhea. The skin of the mangosteen fruit contains xanthones and flavonoids compounds were allegedly able to lower uric acid levels. This study aims to determine the effect of mangosteen peel extract (Garcinia mangostana L.) on uric acid levels in mice (Mus musculus L. Swiss Webster) Males. Research has been conducted in December-January 2016 Biology Laboratory of the Department of Biological Science UNP. This research is experimental method completely randomized design (CRD) ie 4 treatments and 6 replications. Such treatment 0 g / kg (Control / P1), 0.2 g / kg (P2), 0.4 g / kg (P3), 0.6 g / kg (P4). Data were analyzed using ANOVA and using Paired Sample T-Test. Parameters measured were basal uric acid levels before and after treatment. Data taken after 4 days of the treated mice. The results were obtained uric acid levels in mice after treatment are: P1 (Control) 6.43 mg / dL, P2 5.65 mg / dL, P3 3.9 mg / dL, and P4 3.7 mg / dL. Based on the results of this study concluded that the mangosteen rind extract has no effect on uric acid levels in male mice. Keywords: uric acid (gout), xanthine oxidase, hyperuricemia, an antioxidant.

Effect of mangosteen peel extract combined with demineralized freezed-dried bovine bone xenograft on osteoblast and osteoclast formation in post tooth extraction socket

Background: Tooth extraction, a common procedure in dentistry, can cause bone resorption during socket healing. Therefore, it is important to perform socket preservation procedure to maintain alveolar bone. Providing a combination of mangosteen peel extract with demineralized freezed-dried bovine bone xenograft (DFDBBX) in tooth extraction socket was expected to accelerate alveol bone formation. Purpose: This study aims to determine the effect of mangosteen peel extract combined with DFDBBX introduced into the socket of post tooth extraction on the formation of osteoblasts and osteoclasts. Method: Twenty-eight (28) Cavia cobayas were divided into four groups. Extraction to the lower left incisor of Cavia cobaya was performed. The extraction socket was filled with 25 gram of PEG (group I) as a control, active materials consisted of mangosteen peel extract and DFDBBX 0.5% (group II), active materials consisted of mangosteen peel extract and DFDBBX 1% (group III), and active materials consisted of mangosteen peel extract and DFDBBX 2% (group IV). After thirty days, those Cavia cobayas were sacrificed. By using HE on Histopatological examination, the number of osteoblasts and osteoclasts were measured by light microscope with 400 times of magnification. The statistical analysis was then performed using oneway Anova &amp; TukeyHSD test. Result: The component active materials consisted of mangosteen peel extract and DFDBBX 2% had the most significant results related to the formation of osteoblasts and osteoclasts. Conclusion: Mangosteen peel extract combined with DFDBBX can increase osteoblasts and decrease osteoclasts in the socket of tooth extraction in Cavia cobaya. The combination of mangosteen peel extract and DFDBBX 2% is the most effective material in increasing osteoblast and decreasing osteoclast.

Hepatoprotective Effect of Mangosteen Peel Extract on Borax-Induced Male Rats

&lt;p&gt;The aim of this study was to determine the hepatoprotective effect of mangosteen peel extract (MPE) on borax-induced male rats. Hepatoprotective effect is represented by the variables of liver weight, SGOT (Serum Glutamic oxaloacetic transaminase) and SGPT (Serum Glutamic Pyruvate Transaminase). The true experimental study used randomized separated pretest-posttest control group design. MPE was made with 50% ethanol and 0.5% carboxymethyl cellulose-sodium (CMC-Na) stabilizer solutions. Studied groups included three control groups (positive, negative pretest and posttest) and three experimental groups (MPE dose of 200 mg/kg, 400 mg/kg and 600 mg/kg rats body weight (BW)). Samples consisted 36 male rats. The length of intervention was 16 days by providing borax, and then MPE was started on day 3 (in 3 experimental groups). Results showed that up to 16th day the SGOT tended to decrease (α &amp;lt;0.05), while the SGPT levels was stable, and so was the liver weight. Thus, up to day 16 the MPE was generally able to provide hepatoprotective effects mainly based on the variable SGOT in doses of 200 and 400 mg/kg. It has been proved that liver function of the rats was still relatively normal. This is in relations to the antioxidant potential of the MPE polyphenols.&lt;/p&gt;

Hepatoprotective Effect of Mangosteen Peel Extract on Borax-Induced Male Rats

&lt;p&gt;The aim of this study was to determine the hepatoprotective effect of mangosteen peel extract (MPE) on borax-induced male rats. Hepatoprotective effect is represented by the variables of liver weight, SGOT (Serum Glutamic oxaloacetic transaminase) and SGPT (Serum Glutamic Pyruvate Transaminase). The true experimental study used randomized separated pretest-posttest control group design. MPE was made with 50% ethanol and 0.5% carboxymethyl cellulose-sodium (CMC-Na) stabilizer solutions. Studied groups included three control groups (positive, negative pretest and posttest) and three experimental groups (MPE dose of 200 mg/kg, 400 mg/kg and 600 mg/kg rats body weight (BW)). Samples consisted 36 male rats. The length of intervention was 16 days by providing borax, and then MPE was started on day 3 (in 3 experimental groups). Results showed that up to 16th day the SGOT tended to decrease (α &amp;lt;0.05), while the SGPT levels was stable, and so was the liver weight. Thus, up to day 16 the MPE was generally able to provide hepatoprotective effects mainly based on the variable SGOT in doses of 200 and 400 mg/kg. It has been proved that liver function of the rats was still relatively normal. This is in relations to the antioxidant potential of the MPE polyphenols.&lt;/p&gt;

The Effect of Mangosteen Peel Extract on Sperm Motility and Sperm Count of Swiss Webster Mice Induced by Hard Physical Exercise

High-intensity physical exercises can increase oxidative stress, causing damage to reproductive system. The purpose of this study was to determine the effect of mangosteen peel extract on sperm motility and sperm count of Swiss Webster mice induced by high-intensity physical exercise. This was a real experimental with complete randomized design. Twenty five male Swiss Webster mice were divided into five groups (n = 5). Negative control (KN) was without any treatment, positive control (KP) was given treadmill exercise only, the treatment groups (KM1, KM2, KM3) were given mangosteen peel extract orally 2, 4, 8 mg respectively as well as treadmill exercises. The treadmill exercises was conducted for 35 days. The sperm motility (mm/second) and the sperm count (per mm3) were assessed manually using Improved Neaubauer chamber. The result were analyzed using one-way ANOVA followed by Tukey HSD. The result showed high significant differences of sperm motility and sperm count between KM2 and KP, also between KM2 with KM1 and KM3 (p=0,000). The conclusion was mangosteen peel extract improved the sperm motility and sperm count of Swiss Webster mice induced by high-intensity physical exercise with 4 mg as the optimal dose. Keywords: mangosteen peel, sperm motility, sperm count