Effect Of Homeopathic Medicines Research Articles

Role of homoeopathic medicines in acute cases of urinary tract infection in females

Urinary tract infection is the presence of microbial pathogen in normally sterile urinary tract. This study shows that cantharis (60%) act best in acute cases of UTI in female patient. 200 potencies use in 53.33% (16 cases) so, 200potency is mostly used for cure of the patient. : prospective observational method of study. To see the effect of homeopathic medicines in acute cases of UTI in female 30 patients will be included in the study. Sampling technique: random sampling.in this study the maximum prevalence of UTI was noted in the age group of (21-50years). this study shows that cantharis (60%) act best in acute cases of UTI in female patient. From this 30 cases study it was understood that the homoeopathic medicine give a complete cure in 33.33% female patient and relief 40% female of patient only 3.3% female patient having not relief.

Effectiveness of Homeopathic Medicine in Canine Urinary Incontinence: Outcomes of Owner Response Survey

With advances in data collection via electronic surveys, they have become a popular tool for researchers especially with the changes in normalcy caused by the Coronavirus pandemic. During this pandemic period, previously collected traditional format paper data on Homeopet ™ ‘Leaks No More’ was collated, analysed, written up, reviewed, and published Farrington TJ and Smith . The current study was again an owner response survey like the previous studies but done electronically. In the case of this Homeopet™ 'Leaks No More' survey, the selection criteria used to identify eligible participants who had purchased the product directly from the manufacturer's website helped to ensure that the responses collected were from genuine product users including first time and repeat users. This helped to eliminate potential bias in the responses and ensured that the data collected was of high quality. It ensured elimination of spurious responses and replies from unverified users. The use of gratuities only to those who agreed to provide fully completed surveys containing a true assessment of their pets' responses with an email and other contact details including agreement to be contacted helped to improve the response rate and quality of data collected. In fact the normal verifying of email addresses and names of respondents was turned off for data protection requirements after collection before sending data to analyst and authors removing only from them ability to cross-reference to an original mail shot offering the survey to people who had joined the mailing list on Homeopets own sales site, the researchers were after completion of the paper able to ensure that the data collected was authentic and reliable without exposing any personal data for the participants from the survey collection while still ensuring it was verifiable. Despite striving to write the survey questionnaire in a balanced inclusive way so that it would resonate with a wide range of perspectives and viewpoints across a broad range of views, one can assume that those who filled it out were more likely to have been open to complementary medicine or to have a pet who had failed to respond or responded poorly to conventional therapy. It also meant that emails and names could be verified and if necessary, through the email DNS, and thus could be contacted to complete any missing data needed, which thanks to response numbers was not necessary so the data remained completely confidential. As Homeopet ™ ‘Leaks No More’ is an OTC (Over the Counter) retail product which during the pandemic sold primarily online through various online retailers due to the restricted access to bricks and mortar retailers, shops, and stores there was little or no direct access to or contact with the end users and thus the electronic survey proved highly effective in that environment. Overall, electronic surveys have proven to be a more successful and time-efficient way of collecting data compared to traditional methods as shown in this research paper. The high-quality data collected in this study will be valuable for future research and product development in the field of complementary medicine for pets. Methods and Outcomes: An online questionnaire template was developed using questionnaires from the previous studies and he decision was to use SurveyMonkey® as the mode of delivery to participants. Homeopet™ LLC employed an independent consultant to design and develop the front end for owner response input and the back end for data collection. Ms Jenny Doran Halcyon Days Ltd. worked with Dr Farrington and his team, some external individuals unfamiliar with the project (to ensure the public would understand the questionnaire fully), including staff at Homeopet familiar with the process, to test prototype versions of the SurveyMonkey® and tailor them to the projects requirements till the entire team came to a consensus acceptable to Homeopet™ in the time constraints available. The survey was then made available online with an invitation to participate added to the purchase process on the manufacturer’s website. Other online outlets were considered but were not open to the authors having access to their customer information even for verification purposes. This outlet area is being worked on for future surveys.

A case study: Effect of homeopathic medicine on weight loss

A case study: Effect of homeopathic medicine on weight loss

Bioproducts and Homeopathy in Lasiodiplodia Rot (Lasiodiplodia sp.) Control and Development of Passion Fruit Seedlings

The aim of this study was to evaluate the effects of homeopathic medicine Calcarea carbonica 12CH and bioproducts: filtrates of saprobic fungi from Amazon, green propolis nosode 06CH, filtrate of Pichia sp., green propolis extract, Bacillus subtilis; to control Lasiodiplodia (Lasiodiplodia sp.) and development of passion fruit seedlings (Passiflora edulis Sims f. flavicarpa Degener). The experiment was carried out in a completely randomized design with 10 treatments in a parcel divided in time. Each plot consisted of 5 plants for analysis. Data were subjected to analysis of variance and when significant compared by Scott-Knott test (p> 0.05). Variables related to plant growth and the area under the disease progress curve (AUDPC) were evaluated. Assessments were performed at 67, 74 and 82 days after transplantation. There was no reduction in AUDPC for treatments compared to control. As for plant height (cm), the best treatments were Pichia sp. and Gonytrichum sp. with an increase in relation to control of 29.70% and 18.24%, respectively, and increased leaf area (cm2) by 27.42% and 19.85%, respectively. B. subtilis, Pichia sp. and Gonytrichum sp., increased total biomass by 42.31%, 32.82% and 21.44%, respectively. The filtrates application from Pichia sp., Filtrate from Gonytrichum sp., C. carbonica 12CH and B. subtilis provided better performance in the development of passion fruit plants with an increase in the main morphological attributes. The results show that the use of bio products improves the development of seedlings, especially the use of yeast and saprophytic fungi by controlling the biochemical and physiological processes of plants during development.

Antifungal activity of homeopathic medicines against the white mold causing agent Sclerotinia sclerotiorum

White mold disease, caused by fungus Sclerotinia sclerotiorum (Lib.) de Bary., is a disease hard to control due to the high amount of sclerotia produced, which guarantees its survival in the soil for years leading to significant yield losses. Alternative techniques to control the pathogen have been researched, including homeopathy. The present work aimed to evaluate the in vitro antifungal effect of homeopathic medicines on S. sclerotiorum mycelial growth. Homeopathic medicines Sulphur, fungal sclerotium Nosode and Calcarea carbonica, in 30CH, 200CH and 1000CH dynamizations were tested. Assays were carried out in a completely randomized design, with four repetitions. Experiments were performed through the addition of homeopathic medicines on the surface of plates containing culture medium, followed by insertion of a disc containing fungus mycelia and incubation. Control treatment received no homeopathic medicine. The mycelial progression was monitored by seven halo diameter measurements during experiment period. All homeopathic medicines tested and their dynamizations were able to inhibit partially the development of the fungus. Calcarea carbonica at the dynamization of 1000 CH showed the best inhibitory effect on S. sclerotiorum, which under its effect produced a mycelial halo 40% smaller than the control treatment.

Potency dependent activity of homeopathic nanomedicine- classical and quantum electrodynamical approach

The effect of homeopathic medicine on biological and physical system is directly related to its potency [1]. However, from physico-chemical point of view it is difficult to explain this effect at such high dilution, as then the existence of even trace amount of particle is questionable. 
 It has been reported that during the process of potentization, a large amount of mechanical energy gets transferred to the medium due to succussion [2]. This energy in all probability reduces the size of the drug aggregates. The drug then penetrates easily through the membrane barrier, and thereby gives rise to enhanced activity of the medicine.
 It has been experimentally proved by us and supported by others that indeed a reduction of size of the aggregates takes place with increase in potency [3]. Using five different homeopathic medicines, their sizes at three different potencies have been estimated and a general mathematical expression relating the size of the particle (Y) and the corresponding potency (X) has been derived as follows
 Y = a X -n

Effects of homeopathic medicine on physical properties of matter - a classical and QED perspective

Homeopathic medicines affect physical properties of matter which depend on the characteristic and the potency of the medicine1. These effects can be explained from two aspects: (a) classical and (b) quantum electrodynamical. 
 Using three different sets of experiments where homeopathic medicines have affected the physical properties of matter, we have shown how the results can be interpreted from both these points of view.

Effects of homeopathic medicines on macrophage - E. cuniculi interaction in vitro

Encephalitozoon cuniculi (E. cuniculi) is a fungus that behaves as an intracellular parasite infecting different types of cells. In rabbits and immunosuppressed animals of other species, including humans, it parasites neural tissues causing a highly characteristic neurological syndrome, for which repertory analysis indicates Phosphorus. Successful treatment of 7 naturally infected rabbits with Phosphorus confirmed that this medicine probably is the remedy of the ‘epidemic genius’ of microsporidiosis. In the present study, an in vitro model was used to evidence the intracellular relationship between macrophages and E. cuniculi after treatment of co-cultures with different potencies of Phosphorus. RAW 254.7 macrophages were co-cultivated with E. cuniculi and treated with Phosphorus 6cH, 30cH and 200cH. Controls were untreated co-cultures and cultures treated with vehicle (0.06% final alcohol concentration). Phagocytosis and lysosome activity were after after 1 and 24 hours of incubation by means of the calcofluor and acridine orange staining methods, followed by automatic image analysis (Metamorph®). Cytokine production was assessed with the MAGPIX®-Luminex system. The vehicle increased IL-6, MCP-1 and MIP1 production (p

Testicle histomorphometry in senescence/senility under use of homeopathy

Aging is an extremely complex and multifactorial process. Over time, the elderly begin exhibiting signs of function reduction. The aim of the present study was to assess the effects of homeopathic medicines on testicle histomorphometry in senescence/senility. The study was approved by the animal experimentation ethics committee of Santo Amaro University (07/2015). The rats (Wistar, all male, with 22-23 months of age were used) were caged with access to food and water ad libitum and 12-hour light cycle (7:00 am to 7:00 pm). The homeopathic medicines were prepared following the Brazilian Homeopathic Pharmacopoeia. The animals were randomly distributed in 4 groups (n= 6): control; hydroalcoholic solution; Calcarea carbonica 30cH (Calc) and Baryta muriatica 30cH (Bar-m). 5 globules of the medicines were added to each water dispenser; the containers were changed twice per week along 40 days. All investigators were blinded to the allocation groups. After 40 days all the animals were euthanized and the testicles collected. Based on their width and length, the testicles’ volume was calculated by means of the ellipsoid formula. Slides were prepared and stained with PAS. Photographs were taken of the slides with 40x magnification under microscope; software Image J was used to measure the diameter of 50 seminiferous tubules per slide (animal), diameter of the parenchyma and lumen of each tubule. Statistical analysis was performed by means of ANOVA followed by Tukey’s test; the significance level was set to p≤ 0.05. Increase of the testicles’ volume, increased parenchymal diameter and decrease of the tubular lumen was found in groups Calc and Bar-m compared to controls and the group treated with hydroalcoholic solution (p ≤ 0.05). We conclude that the tested homeopathic medicines changed the testicle histomorphometry of animals in senescence/senility. 
 
 Keywords: Testicular histomorphometry, homeopathy, Calcarea carbonica, Baryta muriatica, Senescence/Senility

Clinical Evaluation of Homoeopathic Medicines in Benign Prostatic Hyperplasia

Background Symptomatic benign prostatic hyperplasia (BPH) is a common condition in elderly men and has a significant impact on their daily lives. Surgical procedures are currently used for the conventional treatment for BPH; but they have been associated with clinically significant adverse effects in patients. Objectives The main purpose of this article is to evaluate the role of homoeopathic medicines for the treatment of BPH. Materials and Methods Clinically diagnosed 30 subjects of BPH were given homoeopathy treatment and followed up for a period of 1 year. Homoeopathic medicines were prescribed to the subjects according to the principles of homoeopathy. Effects of homoeopathic medicines were analysed periodically by American Urological Association score (AUA score) and ultrasonography. Results Marked amelioration of symptoms and reduction in size of prostate gland in BPH subjects were observed after homoeopathic treatment when analysed by AUA score and ultrasonography. There was marked reduction in various symptoms of BPH like nocturia, straining, incomplete sensation after urination, interrupted flow of urination with dribbling of urine and urgency significantly from 21.60 ± 4.64 units to 12.23 ± 3.68, that is, ∼57% reduction in symptoms of obstruction of bladder problem. The reduction was statistically significant (p = 0.001). However, transabdominal pelvic ultrasonic scan did not show statistically significant results. Conclusion Homoeopathic medicines can prove to be an alternative treatment of BPH.

English

Multiple in vitro studies using homeopathic medicines are conducted for their effectiveness against various microbes. The reporting of results and the methodology in many studies are a query. The present review reveals the evidence based medicinal effects of homeopathic medicines on various plant and human pathogens in vitro with the help of quality studies. The studies showed positive outcome for homeopathic medicines. Thus, homeopathy is an effective agent in in vitro studies. However, substantial evidence on these serially diluted medicines must be replicated with the help of a standardized methodology for more precise evidences and conclusion.   Key words: Homeopathy, in vitro, manuscript information score, review.

Effect of Homeopathic Medicines and a Nosode on Larvae of Cochliomyia hominivorax (Diptera: Calliphoridae).

Cochliomyia hominivorax is the major fly causing primary myiasis in livestock animals in Brazil; its larvae develop in the host's living tissues, causing mutilations, which can even lead to death. In conventional treatments of myiasis, chemo-synthetic insecticides have been employed directly on larvae present in the wounds. Homeopathy may represent a healthy and sustainable alternative both to prevent and to treat myiasis in animals and humans. The current study evaluated how the emergence of adult insects is affected by the use of the homeopathic medicines Sulfur 12cH and Pyrogenium 12cH, and the nosode produced from C. hominivorax larvae at potencies 8cH and 12cH, on third-stage larvae of a C. hominivorax colony. The homeopathic medicines and the nosodes were produced according to the Brazilian Homeopathic Pharmacopoeia. Control groups were distilled water, alcohol, no substance, and the organophosphate insecticide trichlorfon. For each group, 10 replicates were performed. Emergence rate of adult insects was evaluated by descriptive statistics followed by analysis of variance. Homogeneity of variances was verified by F-test and group means were compared with Tukey's test. Mortality rates in control groups were 2.7% for 30% (v/v) alcohol, 4.3% for distilled water, 3.2% for no substance (p > 0.05). In the trichlorfon group, the mortality rate of larvae was 90.8%. For Sulfur 12cH, the mortality of larvae was 94.6%, and for Pyrogenium 12cH it was 98.6%. The latter three means were not statistically different from each other or from the mean found for the trichlorfon group. The mortality rates of larvae were 61.3% and 66.6% for nosode C. hominivorax 8cH and 12cH, respectively (p > 0.05). Results suggest that homeopathy could be used therapeutically to prevent and treat animals and humans with myiasis caused by C. hominivorax.

An In-Vitro Assay Estimating Changes in Melanin Content of Melanoma Cells due to Ultra-Dilute, Potentized Preparations.

The authors had previously conducted an in-vitro study to observe the effect of homeopathic medicines on melanogenesis, demonstrating anti-vitiligo potential by increasing the melanin content in murine B16F10 melanoma cells. A similar experiment was performed using further homeopathic preparations sourced from kojic acid (KA), hydrogen peroxide (H2O2; HP), 6-biopterin (BP), and [Nle4, D-Phe7]-α-melanocyte-stimulating hormone (NLE), some of which are known to induce vitiligo or melano-destruction at physiological dose. The homeopathic preparations of BP, KA, NLE, and HP were used in 30c potency. Alcohol and potentized alcohol were used as vehicle controls. Prior to starting the main experiment, the viability of B16F10 melanoma cells after treatment with study preparations was assayed. Melanin content (at 48 h and 96 h) and tyrosinase activity in melanocytes were determined. At the end of 48 hours, NLE and HP in 30c potency had a significantly greater melanin content (p = 0.015 and p = 0.039, respectively) compared with controls; BP and KA in 30c potency had no significant effects. No significant changes were seen at the end of 96 hours. KA, NLE, HP, and vehicle controls showed an inhibition of tyrosinase activity. The study demonstrated melanogenic effects of two homeopathic preparations. Further research to evaluate the therapeutic efficacy of these medicines is warranted.

Effect of Homeopathic Medicine (Alfalfa), Methionine and Lysine Supplementation in Low Protein Based Diets on the Performance of Broiler Chicken

An experiment was conducted, with objective to determine the feed consumption, final live weight, weight gain, feed efficiency and economy in broiler chicken fed with locally available low protein based diets (20 percent CP in starter and 18 percent CP in finisher) supplemented with methionine, lysine and homeopathic medicine alfalfa. For this hundred fifty day-old birds of commercial broiler (Vencobb) were randomly assigned to five dietary treatments(10 chicks/treatment) and replicated three times in CRD with treatments composition of low protein based diets (LPB) (T0), LPB+ 100g/100 met + 300g/100 lysine (T1), LPB + 200g/100 met +300g/100lysine (T2), LPB + Alfalfa 5ml/100 chicks 2 day in week with drinking water (T3) and LPB + Alfalfa 5ml/100 chicks 3 day in week with drinking water (T4). Synthetic methionine and lysine was used for supplementation of deficient amino acid. Same condition was applied in finisher diets of broiler chicken. The result showed that chicks fed with LPB in both starter and finisher diet had significantly (P<0.05) lower feed intake, final live weight , total weight gain, feed efficiency and income over feed and chicks cost (IOFCC) with compromising chicks fed with LPB with addition of methionine and lysine each and also homeopathic medicine alfalfa in starter and finisher period. Highest feed intake, final live weight, weight gain, feed efficiency was obtained with treatment (T1) followed by treatment (T2). However, positive growth response and better health status of chicks was also observed from supplementation of homeopathic medicine alfalfa with LPB and non-significant difference on Income Over Feed and Chicks Cost was obtained with treatment (T1). So, it was concluded that with supplemental methionine, lysine and alfalfa, the CP level of broiler chicks could be reduced up to 20 percent in starter and 18 percent in finisher diets without adverse effect on feed intake, final live weight, weight gain, feed efficiency and Income overfeed and chicks cost, provided under locally based feed ingredients.Int. J. Appl. Sci. Biotechnol. Vol 6(2): 174-180

Effectiveness of Homeopathic Medicines as Add-on to Institutional Management Protocol for Acute Encephalitis Syndrome in Children: An Open-Label Randomized Placebo-Controlled Trial.

Acute encephalitis syndrome (AES) is endemic to certain parts of India, with limited treatment options. In our initial exploratory comparative observational study of 151 patients with AES, there was significantly reduced mortality with adjunctive homeopathy compared to institutional management protocol (IMP). The present randomized placebo-controlled trial brings more statistical rigor to this research program. This study was conducted at a pediatric unit from 2013 to 2015. Children aged > 6 months and ≤ 18 years and receiving IMP were randomized to receive adjunctive homeopathy (n = 325) or placebo as control (n = 323). The primary effectiveness analysis was based on Glasgow Outcome Scale (GOS). Morbidity was assessed using the Liverpool Outcome Score for Assessing Children at Follow-up. Analysis was by intention to treat. A total of 612 children were analyzed (Homeopathy [H] = 304; Control [C] = 308). The primary outcome, GOS, differed significantly between H and C groups. There was 14.8% death/neuro-vegetative state in the H group compared to 29.8% in the C group. Relative risk was 0.49 (95% confidence interval [CI]: 0.36 to 0.68), with absolute risk reduction of 15.0% (95% CI: 8.6 to 21.6%). Number needed to treat to prevent one additional death/neuro-vegetative state was 6.6 (95% CI: 4.6 to 11.6). Proportional-odds analysis also revealed a greater effect in the H group: odds ratio, 0.40 (95% CI: 0.27 to 0.60). The most frequently used medicines were Belladonna (n = 116), Stramonium (n = 33), Arsenicum album (n = 25), Sulfur (n = 18), Opium (n = 17), and Nux vomica (n = 10). Adjunctive homeopathic medicines may improve clinical outcomes associated with AES. Further randomized and controlled studies, using double-blinded trial design, are recommended to discover if the current findings may be corroborated.

Low back pain: Correlation with anxiety, depression, and well-being and the effect of homeopathic medicines on the physical signs of patients

Background: This study was intended to prove or disprove the accusations that the homeopathic medicines are nothing but placebo by evaluating the reduction in the physical signs in patients with pathological low back pain (LBP). Objectives: The present study was conducted to evaluate the relationship between pain and anxiety, pain and depression, and pain and well-being among patients with somatoform LBP and patients with pathological LBP and also to evaluate the reduction in the physical signs in patients with pathological LBP after treated with homeopathic medicines, placebo, and homeopathic medicines in combination with placebo. Materials and Methods: The sample consisted of 439 patients including patients with pathological LBP and somatoform LBP. The patients in these two categories were further classified into three groups based on the type of intervention used such as patients treated with homeopathic medicines, placebo, and homeopathic medicines in combination with placebo. Results: From this study, it can be concluded that there is a positive correlation between pain and anxiety and pain and depression, whereas there is a negative correlation between pain and well-being among patients with somatoform LBP and patients with pathological LBP. Conclusion: The study had shown that the homeopathic therapy was capable of improving the physical signs among patients with somatoform LBP and patients with pathological LBP. Homeopathic medicines in combination with placebos too could produce a significant difference in physical signs when compared to the results with that of placebo.

The Effects of Homeopathic Medicines on Reducing the Symptoms of Anxiety and Depression: Randomized, Double Blind and Placebo Controlled

Background: Anxiety and depression are two of the most prevalence psychological disorders in the world. Objective: This study investigates the effects of homeopathic medicine on reducing the symptoms of anxiety and depression. Method: According to the procedure, thirty patients (twenty female and ten male) with the mean age of 45 (range 22-67) were selected randomly and classified in two experimental and controlling groups. The patients were evaluated based on Beck Depression Inventory (BDI) and Spielberger State-Trait Anxiety Inventory (STAI)-Y. The Pretest – posttest, and follow-up pattern was designed, homeopathic remedies were used and analysis of covariance with repeated measures is used for data analysis. Results: Findings depict significant differences (P<0.01) between two stages of intervention and sustaining of this effectiveness is shown in following-up procedure. Conclusion: These findings suggest that homeopathic therapy can be used as an effective method to treat anxiety and depression disorders.

Effectiveness of homeopathic medicines as add on to institutional management protocol for Acute encephalitis syndrome (AES) in children – An observational comparative study

Effectiveness of homeopathic medicines as add on to institutional management protocol for Acute encephalitis syndrome (AES) in children – An observational comparative study

A randomised, double blind, placebo-controlled, multi-centric parallel arm trial to assess the effects of homoeopathic medicines on chronic rhinosinusitis

Background: Chronic rhinosinusitis (CRS) is one of the most common illnesses interfering with patient's quality of life and work. Observational studies conducted by the Council indicate positive outcome. This protocol has been developed to ascertain the usefulness of homoeopathic intervention in comparison with control group in a randomised control setting. Objectives: Primary objective is to evaluate the changes in TSS (Total Symptoms Score) and SNOT-22 (Sino-nasal Outcome Test-22) within the two groups of the study (Homoeopathy + Placebo). Secondary objective is to evaluate changes in SNOT-22 at end of the trial, changes in Lund and Mackay staging of CT scan, rhinoscopy grading, absolute eosinophil count, global assessment by investigator and patient, and number of acute exacerbations of CRS (for frequency, duration and intensity) as per TSS scale compared to placebo. Methods/Design: This is a randomised double blind, placebo-controlled, multi-centric parallel arm trial of 6 months (three months treatment and three months observation period) with 14 days run-in period. The primary outcome is a composite of the changes in the TSS and SNOT-22 over 3 months from baseline with area under the curve and changes over 3 months in the Sinus Nasal Outcome Test 22 (SNOT-22) from baseline. Prescription shall be made as per the homoeopathic principles. Efficacy data will be analysed in the intention-to-treat population. Discussion: This trial will help to evaluate the efficacy of homoeopathic individualised treatment using LM-potencies versus placebo in patients suffering from CRS as per the homoeopathic dictum.

Induction of Apoptosis of Tumor Cells by Some Potentiated Homeopathic Drugs

Homoeopathic medicines treat diseases, including cancer, using ultradiluted preparations. Earlier studies indicated that homoeopathic medicines are cytotoxic to tumor cells and reduced animal tumors. However, the mechanism of homoeopathic medicines at the cellular level is not known. The following drugs were used in the study: Ruta 200C, Carcinosinum 200C, Hydrastis 200C, Thuja 200C, and Thuja 1M. These drugs were tested for their ability to induce apoptosis as seen by morphology, DNA laddering, expression of genes related to apoptosis, and TUNEL assay. Similarly, the effect of homoeopathic medicines on apoptosis was measured by microarray analysis. Activity of Ruta 200C was compared with that of the mother tincture. Ruta 200C produced morphological changes in the Dalton's lymphoma ascites tumor cells and induced DNA laddering. Carcinosinum 200C increased apoptotic gene p53 and Ruta 200C decreased antiapoptotic gene Bcl2. Administration of potentiated homoeopathic drugs to tumor-bearing mice induced TUNEL-positive cells in the tumor, showing increased apoptosis of tumor cells. Microarray analysis of cells treated with homoeopathic drugs indicated that many enzymes related to apoptosis were increased by homoeopathic drugs. These data indicate that apoptosis is one of the mechanisms of tumor reduction of homeopathic drugs. A comparison of potentiated drugs with their mother tincture indicated that the potentiated drugs have biological activity similar to that of their mother tincture in spite of ultradilution.