Helium diffusion is a very critical factor for designing a plasma facing components of fusion reactor. Because it not only reduce the thermal conductivity but also degrade the surface morphology of tungsten based materials. In this numerical study the specimens of tungsten, vanadium and tungsten vanadium alloys have been simulated under thermo-diffusion conditions. The finite element commercial software Abaqus was used for simulation to obtain helium diffusion profile at temperature of 800 K for concentration of1024number of atoms in tungsten and vanadium metals. Due to its relatively low helium diffusion coefficient, vanadium has shown better resistance against helium penetration as compared to tungsten. Subsequently the analytical effect of helium diffusion in tungsten, vanadium and different grades of tungsten vanadium alloys has been investigated. To study the distribution of vanadium in tungsten, tungsten vanadium alloys were fabricated by spark plasma sintering technique and its morphology has been analyzed by scanning electron microscopy.