Effects Of HbA1c Levels Research Articles

Effect of HbA1c Level on Vestibular system Among Patients with Diabetic Mellitus

Effect of HbA1c Level on Vestibular system Among Patients with Diabetic Mellitus

Effect of HbA1c Level on Hearing Sensitivity Among Patients with Diabetic Mellitus

Diabetes Mellitus (DM) appears to be a risk factor for hearing loss. Meta-analyses of cross-sectional studies reported that diabetes had a greater risk of hearing impairment. Hearing loss and hemoglobin A1c (HbA1c), a glycemic management biomarker, have been linked in a few studies. HbA1c and hearing impairment as measured by a pure-tone average threshold of frequencies (500 Hz, 1 kHz, and 2 kHz), while the other two found a link between HbA1c and high-frequency hearing impairment. The goal of this study is to see if the amount of HbA1c level is linked to the occurrence of hearing loss. Participants were 430 of both genders between the ages of 21 to 60 years and based on the duration of HbA1c level. Results indicated that the higher HbA1c level patient had high-frequency hearing loss when compared to speech frequencies in both ears. As the HbA1c level increases an increase in the high-frequency hearing loss was also noticed. A positive correlation exists between the duration of diabetics and high-frequency hearing loss. Moreover, when diabetic duration increases, the hearing loss is more affected in extended high frequency, high frequency followed by speech frequency among uncontrolled DM than controlled DM in both ears. These findings suggest that proper glycemic management might help avoid diabetic hearing loss.

The Effect of HbA1c Level on Gender-Specific Long-Term Morbidity and Mortality After Isolated Coronary Bypass in Poorly Controlled Diabetic Patients

Objective: The aim of this study is to evaluate the gender specific effects of the high HbA1c levels in poorly controlled diabetic patients undergoing isolated coronary artery bypass grafting (CABG) procedure on long term morbidity, mortality and re-revascularization (2nd intervention). Methods: This study was conducted on 532 (346 (65%) males and 186 (35%) females) diabetic patients who underwent CABG procedure at a single center between January 2010 and December 2013.The patients were separated into 4 groups according to gender and preoperative HbA1c level (%). The group1 consisted of females with HBA1c level ≤7(n=46); the group 2 comprised female with HbA1c level >7(n=140); the group 3 comprised men with HbA1c level ≤7(n=117); and the group 4 comprised men with HbA1c level >7(n=229). The groups were analyzed and compared for postoperative complications and mortality. Results: No statistically significant difference was found among the groups in HbA1c levels and gender with respect to postoperative infection and mortality (p>0.05). The HbA1c level was determined to be statically significant and required the 2ndintervention (p:0.001; 95% CI: 1.249 (1.055,1.478)). Conclusion: This study suggested that there was no difference in mortality rates after CABG among the groups although the current risk calculator modules stated otherwise. However, the HbA1c levels were associated with a need for a secondary intervention on long term follow up period.

SAT-153 CORRELATION BETWEEN HBA1c LEVEL AND RENAL FUNCTION IN DIABETIC NEPHROPATHY

Tight glycemic control may have limited effect on the protection of renal function. No large clinical trials conducted since 2000 have clearly shown that the management goal of HbA1C is 6% better than 7%. In addition, recent clinical trials of many new drugs have compared the HbA1c levels of 8% and 7% groups. Therefore, in this study, HbA1C was divided into each stratum by 1%, and the effect of HbA1c level on renal function was examined. This single-center retrospective observational study examined the HbA1C and Cr data of patients for five consecutive years between 2007 and 2017, beginning from the date of the first measurement of HbA1C. Annual mean values were used as representative values for blood tests. Considering the possibility of a high HbA1C level in the first year, the mean HbA1C level after year 2 was calculated, and the four groups (6%, 7%, 8% and 9%) were compared. Primary endpoints were mean estimated glomerular filtration rate (eGFR) slope and the proportion of patients with rapid renal insufficiency (≥ 5 mL/min/1.73 m2/year). Dialysis patients and those aged 18 years or younger were excluded from the study. The HbA1C 6%, 7%, 8% and 9% groups consisted of 630, 399, 95, and 23 subjects, respectively. The mean ages of these groups were 64.6, 65.0, 60.6, and 61.0 years, respectively, and the mean HbA1C during the course was 6.5 ± 0.3, 7.4 ± 0.3, 8.4 ± 0.3, and 9.4 ± 0.3, respectively. The mean eGFR at 1 year was 69.6, 70.7, 75.7, and 78.4 ml/min/1.73 m2, respectively. The higher the HbA1C level, the greater was the eGFR slope. The eGFR slopes were -1.2 ± 2.8, 1.2 ± 2.7, 1.5 ± 3.3, and 2.6 ± 3.6 mL/min/1.73 m2/year for the four groups, respectively. The incidence of rapid decreased renal function was 7.3%, 6.5%, 10.5% and 21.7% for HbA1C 6%, 7%, 8% and 9% groups, respectively, showing similar tendency with the eGFR slope. Furthermore, only the 6% and 7% groups were analyzed by matching background factors, but no significant difference was found (P = 0.74). In the present study, there was no significant difference in either the eGFR slope or the percentage of patients with rapid decreased renal function between HbA1C in the 6% and 7% ranges.

Quantitative analysis of the effect of HbA1c level on macular microcirculation in patients with type 2 diabetes mellitus

Objective To observe and analyze the effect of HbA1c level on macular microcirculation in patients with type 2 diabetes mellitus (T2DM). Methods A cross-sectional study. One hundred and twenty-four T2DM patients (124 eyes) without diabetic retinopathy who diagnosed by the examination of fundus color photography in Lixiang Eye Hospital Of Soochow University during September to December 2017 were enrolled in this study. There were 59 males (59 eyes) and 65 females (65 eyes), with the mean age of 65.06±7.99 years old. All patients underwent BCVA, fundus color photography, and OCT angiography (OCTA). The history of diabetes, hypertension and dyslipidemia were recorded in detail. According to the HbA1c level, patients were divided into three groups, HbA1c ideal control group (group A, HbA1c 9%, 13 eyes), respectively. The 3 mm×3 mm range of the macular area was scanned by OCTA instrument. The vascular density (VD) and skeleton density (SD) of nonsegmented retinal layer (NRL), superficial retinal layer (SRL) and deep retinal layer (DRL) in the macular area and foveal avascular zone (FAZ) area, non-circularity index, axial rate (AR) of SRL were measured. The correlation between HbA1c, BCVA and VD, SD of NRL, SRL, DRL was analyzed statistically with Spearman correlation test. The correlation between systemic factors and the above indicators was analyzed statistically with linear regression analysis. Results The results of linear regression analysis showed that HbA1c was significantly correlated with VD (t=−3.237, −3.156, −2.050) and SD (t=−0.3.45, −3.034, −2.248) of NRL, SRL and DRL (P 0.05). The differences of VD (F=6.349, 5.981, 3.709), SD (F=7.275, 6.085, 1.904) and AR (F=0.027) of NRL, SRL and DRL in group A, B and C were statistically significant (P 0.05). Significant differences (P 0.05). Conclusion The decrease of macular perfusion and the morphological change of FAZ accompanied by HbA1c increased. Key words: Diabetes mellitus, type 2; Hemoglobin A, glycosylated; Microcirculation; Tomography, optical coherence

Effect of HbA1c Level on Discharge Modified Rankin Scale Who Received rt-PA in Acute Ischemic Stroke (P01.224)

Effect of HbA1c Level on Discharge Modified Rankin Scale Who Received rt-PA in Acute Ischemic Stroke (P01.224)