The process of foreign object impact on Alloy 690TT steam generator (SG) tubes under high-speed water flow was simulated using quasi-static indentation method. Morphologies of foreign object damage (FOD) were detailed characterized, and the fatigue curves and fatigue strengths were acquired for smoothed and three types of FOD-affected specimens. Results indicated that the fatigue strength of the impacted specimens reduced with the increase of defect depth, and there was an exponential relationship between fatigue strength and defect depth. Fatigue cracks all initiated at the root of the defect groove, and as the depth of defect increased, the number of fatigue crack sources gradually increased. Finally, the fatigue strength was predicted by the fatigue notch factor and damage tolerance method, and the fatigue performance evaluation diagram of the SG tube damaged by foreign object based on El Haddad model was established.