Effect Of Flurbiprofen Axetil Research Articles

Flurbiprofen axetil is involved in basal-like breast cancer metastasis via suppressing the MEK/ERK signaling pathway.

Flurbiprofen axetil is commonly utilized in clinical practice as one of the nonsteroidal anti-inflammatory drugs (NSAIDs) and is included in multimodal analgesia regimens postbreast cancer surgery. Numerous NSAIDs have been studied for their potential to both promote and inhibit cancer. Given the variability in their effects on tumors, further investigation into the specific role of flurbiprofen axetil is warranted. Therefore, the primary objective of this study was to assess the impact of flurbiprofen axetil on basal-like breast cancer (BLBC) metastasis and elucidate the underlying molecular mechanisms involved. The BLBC metastasis mouse model was established by caudal vein injection of tumor cells. The lung metastasis of breast cancer in mice and the effect of flurbiprofen axetil were assessed by in vivo bioluminescence imaging, hematoxylin and eosin staining and immunohistochemistry. In vitro, the results of flurbiprofen axetil on the proliferation, migration, and invasion of MDA-MB-231 human breast cancer cells and BT-549 human breast cancer cells were assessed by colony formation assay and transwell assay. The effects of flurbiprofen axetil on several tumor metastasis-related signaling pathway proteins were examined by western blot, and the reversal extent of the flurbiprofen axetil effect by Ro 67-7476 (ERK phosphorylation agonist) was detected by transwell assay. The results showed that flurbiprofen axetil significantly inhibited BLBC lung metastasis in mice. Flurbiprofen axetil similarly inhibited breast cancer cell migration and invasion in vitro but did not affect their proliferation. Mechanistic investigations have revealed that flurbiprofen axetil exerts a noteworthy inhibitory influence on the MEK/ERK pathway while exhibiting no significant alteration in the expression of other pathway proteins intricately associated with epithelial-mesenchymal transition. In conclusion, the inhibitory effect of flurbiprofen axetil on BLBC metastasis is characterized by its selectivity in targeting the MEK/ERK signaling pathway rather than exerting a broad impact on the global signaling pathway.

Effect of flurbiprofen axetil on pain and cognitive dysfunction after radical operation of cervical cancer in elderly patients.

article: Effect of flurbiprofen axetil on pain and cognitive dysfunction after radical operation of cervical cancer in elderly patients - Minerva Surgery 2022 October;77(5):525-7 - Minerva Medica - Journals

Effect of flurbiprofen axetil combined with "Cocktail" therapy on opioid dosage in patients after total knee arthroplasty.

Objectives:To investigate the effect of flurbiprofen axetil combined with “cocktail” therapy on opioid dosage in patients after total knee arthroplasty (TKA).Methods:The clinical data of 200 patients who underwent TKA in Baoding No.1 Central Hospital hospital from March 2019 to March 2021 were collected for retrospective analysis. All 200 patients were divided into two groups according to their intraoperative anesthesia methods: the control group (100 cases) and the experimental group (100 cases). Patients in the control group were treated with “cocktail” therapy intraoperatively, while those in the experimental group were treated with flurbiprofen axetil combined with “cocktail” therapy intraoperatively. The hip pain scores in resting state and motion state were compared between the two groups at different postoperative time points, and postoperative pain relief, adverse reactions, and patient satisfaction with analgesia were statistically analyzed to evaluate the postoperative quality of life of the patients.Results:A statistically significant difference was observed in the intergroup and temporal effects of pain scores in resting state and motion state between the two groups (p<0.05). By comparison at each time point, the pain scores in the experimental group were significantly lower than those in the control group at the time point T1-T6 in resting and motion states, with a statistically significant difference (p<0.05). The frequency and dosage of remedial medication per capita in the experimental group were significantly lower than those in the control group, with a statistical significance (p<0.05). There was no significant difference in the scores of life quality items between the two groups preoperatively (p>0.05), while the scores of each item in the experimental group were significantly higher than those in the control group postoperatively (p<0.05). The satisfaction degree of the experimental group was significantly higher than that of the control group, showing a statistically significant difference (p<0.05).Conclusions:Flurbiprofen axetil combined with “cocktail” therapy is a safe treatment regimen that can improve the quality of life and safety of patients. With such a regimen, postoperative pain of patients undergoing TKA can be effectively relieved, and the use of opioids can be reduced.

Effect of Flurbiprofen Axetil on Postoperative Analgesia Following Abdominal Surgery: a Single-Center, Prospective Randomized Controlled Trial

Flurbiprofen axetil has been proved as an alternative analgesia for postoperative pain. The aim of this study was to investigate the effects of different strategies of flurbiprofen axetil administration on postoperative pain. A total of 160 patients undergoing abdominal surgery were randomly assigned to four groups (n = 40 each): (A) 30 min before the start of surgery, the group was given 1 mg/kg flurbiprofen, then the intravenous patient-controlled analgesia (PCIA) pump contained 0.7μg/kg sufentanil, 1 mg/kg flurbiprofen axetil, 10 mg tropisetron, and 0.4 mg/kg dezocine. (B) The group received 1 mg/kg flurbiprofen axetil before surgical suture, and the PCIA pump was same as group A. (C) The group received no flurbiprofen axetil during operation, but the PCIA pump contained 1 μg/kg sufentanil, 2 mg/kg flurbiprofen axetil, 10 mg tropisetron, and 0.4 mg/kg dezocine. (D) The group was given 1 mg/kg flurbiprofen axetil at 30 min prior to the beginning of surgery and before surgical suture simultaneously, and PCIA pump was the same as group C, but flurbiprofen axetil was not used. Visual Analog Scale at rest/movement (VAS-R/M), sedation score, comfort score, and side effects were observed 48 h postoperatively. Preoperative or intraoperative intravenous flurbiprofen axetil injection decreased the VAS at 8 h, 12 h, and 24 h after surgery compared with postoperative PCIA contained flurbiprofen axetil. VAS scores at rest with intravenous flurbiprofen axetil at 30 min prior to the start of surgery were significantly decreased compared to that before surgical suture at 2 h, 8 h, and 48 h postoperatively. Flurbiprofen axetil ameliorates postoperative pain of patients with abdominal surgery, enhances analgesic effects of sufentanil, and decreases the consumption of sufentanil.

Effect of flurbiprofen axetil combined with lung-protective ventilation on postoperative cellular immune function in patients undergoing thoracoscopic radical resection of lung cancer

Objective To investigate the effect of flurbiprofen axetil combined with lung-protective ventilation on postoperative cellular immune function in the patients undergoing thoracoscopic radical resection of lung cancer. Methods Eighty American Society of Anesthesiologists physical status Ⅰor Ⅱ patients of both sexes, with no abnormal lung function during the preoperative examination, aged 35-64 yr, with body mass index of 18-28 kg/m2, scheduled for elective thoracoscopic radical resection of lung cancer under general anesthesia, were divided into 4 groups(n=20 each)using a random number table method: conventional mechanical ventilation group(group C), flurbiprofen axetil combined with conventional mechanical ventilation group(group F+ C), lung-protective ventilation group(group P)and flurbiprofen axetil combined with lung-protective ventilation group(group F+ P). Flurbiprofen axetil 2 mg/kg was intravenously injected at 5 min before induction of anaesthesia in F+ C and F+ P groups.Patients were mechanically ventilated in volume-controlled mode in four groups.Conventional ventilator settings were adjusted with tidal volume(VT)10 ml/kg and respiratory rate 10-20 breaths/min during two-lung ventilation and with VT 8 ml/kg and respiratory rate 13-16 breaths/min during one-lung ventilation.Lung-protective ventilator settings were adjusted with VT 8 ml/kg and respiratory rate 12-14 breaths/min during two-lung ventilation and with positive end-expiratory pressure 5 cmH2O, VT 6 ml/kg and respiratory rate 14-16 breaths/min during one-lung ventilation.All patients received patient-controlled intravenous analgesia(PCIA)at the end of surgery until 24 h after surgery.PCIA solution contained sufentanil 100 μg and ondansetron 16 mg in 100 ml of normal saline in group C and group P. PCIA solution contained sufentanil 100 μg, flurbiprofen axetil 2 mg/kg and ondansetron 16 mg in 100 ml of normal saline in group F+ C and group F+ P.The PCIA pump was set up with a 0.5 ml bolus dose, a 15-min lockout interval and background infusion at a rate of 2 ml/h.Visual analog scale score was maintained ≤3.When visual analog scale score >3, tramadol 2 mg/kg was intravenously injected.Before induction of anesthesia(T0), at the end of surgery(T1), at 24 and 72 h after surgery(T2, 3)and at 1 week after surgery(T4), blood samples were collected from the central vein for measurement of the levels of T lymphocyte subsets CD3+ , CD4+ , CD8+ and NK cells.The CD4+ /CD8+ ratio was calculated. Results Compared with the baseline at T0, the levels of CD3+ , CD4+ and NK cells and CD4+ /CD8+ ratio were significantly decreased at T1-3 in C, F+ C and P groups and at T1, 2 in group F+ P(P<0.05). Compared with group C, the levels of CD3+ , CD4+ and NK cells and CD4+ /CD8+ ratio were significantly increased at T1-3 in the other three groups(P<0.05). Compared with group F+ C or group P, the levels of CD3+ , CD4+ and NK cells and CD4+ /CD8+ ratio were significantly increased at T1-3 in group F+ P(P<0.05). Conclusion Flurbiprofen axetil combined with lung-protective ventilation improves postoperative cellular immune function and provides better efficacy than either alone in the patients undergoing thoracoscopic radical resection of lung cancer. Key words: Cyclooxygenase inhibitors; Respiration, artificial; Immunity, cellular; Thoracoscopy

Effect of flurbiprofen axetil for postoperative analgesia on blood coagulation: a meta-analysis

Objective To analyze the effect of flurbiprofen axetil (FA) on blood coagulation in patients undergoing surgery through systematic review and meta-analysis. Methods PubMed, WanFang and CNKI databases were searched from their establishment to August 2017 by computer retrieval for relevant literature on the blood coagulation effect of FA. The references of the studies included were also searched by hand. Two reviewers independently screened the literature, extracted data from full-text articles, and evaluated the methodological quality of included studies. All data were analyzed by Review Manager 5.3. Results Altogether 11 studies were finally included, consisting of 10 RCTs and one case-control study, involving 643 patients undergoing surgery. The mean Jadad score for all the studies included were less than 3, suggesting low methodological quality of the studies included. The pool analysis of 4 blood coagulation indexes (prothrombin time, thrombin time, activated partial thromboplastin time and fibrinogen) and platelet count showed that there were no significant differences between the control group and flurbiprofen axetil group before treatment and at 30 min, 1-2 h, 6-8 h, 12 h, 24 h and 48 h after treatment (P>0.05) . As for other outcomes like Sonoelot coagulation indexes [activated clotting time of whole blood, coagulation rate and platelet function (PF)], time to peak, mean platelet volume, maximum platelet aggregation rate, platelet aggregation rate at 1 min (PAG1), platelet aggregation rate at 5 min (PAG5) and platelet aggregation rate maximum, no significant differences were found except in one study where PF was found to be lower at 2 h after treatment in the FA group than in the control group. Conclusion Use of FA in common clinical doses is safe for postoperative analgesia, because blood coagulation may not be significantly affected. Key words: Systematic review; Analgesia; Posoperative period; Flurbiprofen axetil; Blood coagulation

Therapeutic effects of flurbiprofen axetil on mesenteric traction syndrome: randomized clinical trial

BackgroundThis study aimed to reveal the appropriate timing for the intravenous administration of flurbiprofen axetil for preventing mesenteric traction syndrome (MTS), caused by prostacyclin release.MethodsIn this prospective, randomized, clinical study, forty-five patients who were undergoing elective surgery for colorectal cancer via laparotomy were enrolled. Patients were randomly divided into 3 groups: a preoperative group (n = 16) receiving flurbiprofen axetil directly before surgery; a post-MTS group (n = 14) receiving following MTS onset; and a control group (n = 15) who were not administered flurbiprofen axetil. 6-keto-PGF1α, a stable metabolite of prostacyclin, levels were measured and mean blood pressures were recorded.ResultsIn the preoperative group, 6-keto-PGF1α levels did not increase, blood pressure levels did not decrease, and no facial flushing was observed. In both the post-MTS and control groups, 6-keto-PGF1α levels increased markedly after mesenteric traction and blood pressure decreased significantly. The post-MTS group exhibited a faster decreasing trend in 6-keto-PGF1α levels and quick restore of the mean blood pressure, and the use of vasopressors and phenylephrine were lower than that in the control group.ConclusionsEven therapeutic administration of flurbiprofen axetil after the onset of MTS has also effects on MTS by suppressing prostacyclin production.Trial registrationClinical trial number: UMIN000009111. (Registered 14 October 2012)

Effects of flurbiprofen axetil administered at different time points on oxygenation in patients undergoing one-lung ventilation

Objective To evaluate the effects of flurbiprofen axetil administered at different time points on oxygenation in the patients undergoing one-lung ventilation(OLV). Methods Ninety patients of both sexes, aged 45-64 yr, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ, undergoing elective thoracoscope-assisted pulmonary lobectomy, were assigned into 3 groups(n=30 each)using a random number table: control group(group C), preoperative administration group(group F1)and intraoperative administration group(group F2). Flurbiprofen axetil (10 mg/ml) and fat emulsion 10 ml were injected intravenously at 15 min before operation in F1 and C groups, respectively.Flurbiprofen axetil 10 ml was intravenously injected immediately after the beginning of OLV in group F2.At 15 min before operation(T1), 15 and 30 min of OLV(T2, 3), and 15 min after restoration of two-lung ventilation(T4), airway peak pressure(Ppeak)and dynamic lung compliance(Cdyn)were recorded, arterial blood samples were collected for blood gas analysis.The arterial oxygen partial pressure(PaO2)was recorded, and the oxygenation index(OI)and intrapulmonary shunt(Qs/Qt)were calculated.The concentrations of thromboxane B2(TXB2)and 6-keto-prostaglandin F1α(6-K-PGF1α)in serum were measured by enzyme-linked immunosorbent assay, and TXB2/6-K-PGF1α ratio was calculated.The development of interrupting OLV due to SpO2<90% and postoperative dyspnea, pulmonary infection, atelectasis and length of hospital stay were recorded. Results Compared with group C, PaO2 and OI were significantly increased, and Qs/Qt was decreased at T2, 3, the serum concentrations of TXB2 and 6-K-PGF1α were decreased, and TXB2/6-K-PGF1α ratio was increased at T2-4, the incidence of interrupting OLV was decreased(P 0.05). Compared with group F1, PaO2 and OI were significantly decreased at T2, 3, Qs/Qt was increased at T2, and the serum concentrations of TXB2 and 6-K-PGF1α were increased, and TXB2/6-K-PGF1α ratio was decreased at T2-4 in group F2(P 0.05). Conclusion Flurbiprofen axetil injected at 15 min before operation can significantly improve oxygenation and prevent the development of hyoxemia in the patients undergoing OLV, however, flurbiprofen axetil administered immediately after the beginning of OLV has no such effect. Key words: Flurbiprofen; Pulmonary gas exchange; Respiration, artificial

Effects of flurbiprofen axetil combined with celecoxib on patients with lumbar disc herniation and nursing experience

目的 探讨氟比洛芬酯联合塞来昔布治疗急性腰椎间盘突出症疼痛的临床效果和护理经验。 方法 选择平阳县人民医院2015年1～12月收治的60例急性腰椎间盘突出症患者为研究对象，在保守治疗腰椎间盘突出症的同时，全程做好心理疏导，针对性护理以及夜间联合用药疗法，观察患者治疗效果。 结果 60例患者经药物保守治疗及护理后，好转率为93.33%，无效率为6.67%。 结论 保守治疗联合药物疗法加上适当的护理能有效减轻及缓解腰椎间盘突出症夜间疼痛，采取夜间加服塞来昔布药物对症治疗，并加强心理护理等各项护理措施，能有效减轻疼痛，提高患者生活质量。

Flurbiprofen axetil preconditioning allivates inhalation lung injury in rats

Objective To investigate the protective effects of flurbiprofen axetil(FA)on inhalation lung injury induced by lipopolysaccharides(LPS)inhalation in rats,so as to provide evidence for applying FA in treating inhalation lung injury in clinic.Methods A total of 96 adult male Sprague-Dawley rats were evenly randomized into four groups(n=24):saline negative control group(NS group),model group(LPS group),lipid emulsion preconditioning control group(Lip+LPS group),and FA preconditioning group(FA+LPS group).The model of inhalation lung injury was established with endotracheal instillation of LPS(1mL/kg)in all experimental groups.NS group was identical to the other three groups except that saline(1mL/kg)was administered instead of LPS.Lipid emulsion(20%,1mL/kg)or FA injection(1mL/kg,10mg/mL)was intravenously injected via vena caudalis 1hour before LPS in Lip+LPS and FA+LPS groups,respectively.Rats were sacrificed at 1h,6h,12hand24 hafter LPS injection and assigned to 1h,6h,12 hand 24hsubgroups(n=6).The arterial blood gas was analyzed and the lungs were removed for determination of the wet/dry mass(W/D)ratio and evaluation of histological injury in all groups.Real-time PCR was used to detect the mRNA levels of PPAR-αand PPAR-γin rats lung homogenates.The concentration of tumor necrosis factor-alpha(TNF-α)in rat serum was determined by ELISA.Results The rats in LPS and Lip+LPS groups showed damaged structure of lung tissue and inflammation.The mRNA levels of PPAR-αand PPAR-γin the lung tissues of LPS group were significantly lower than those of NS group(P0.05).The serum concentration of TNF-αof LPS group was significantly higher than that of NS group(P0.05).The pulmonary lesions in FA+LPS group were ameliorated compared with those in LPS and Lip+LPS groups.Pressure of oxygen in arterial blood(PaO2)was signficantly higher and semiquantitative pathological score of lung was signficanlty lower in FA+LPS group than those in LPS and Lip+LPS group at 6h,12 hand 24hafter injection(P0.05).The mRNA levels of PPAR-αand PPAR-γin rat lung tissues of FA+LPS group were signficanlty higher than those of LPS and Lip+LPS groups at all times,especially,at 6hafter the intravenous injection of LPS(P0.05).The serum concentration of TNF-αof FA+LPS group was significantly lower than that of LPS and Lip+LPS groups at all times,expecially,at 1hafter the intravenous injection of LPS(P0.05).Conclusion FA preconditioning can alleviate the inflammation and protect inhalation injury to lung tissues induced by LPS in rats,which may involve the upregulation of PPAR-αand PPAR-γ mRNA levels in rat lung tissues and the down-regulation of serum TNF-α.

Influence of flurbiprofen axetil for preemptive analgesia on stress response during recovery period in neurosurgical patients

Objective To investigate the effects of flurbiprofen axetil for preemptive analgesia on hemodynamics and stress levels in patients undergoing neurosurgery.Methods 60 patients undergoing neturosurgery were enrolled in the study.The patients were randomly divided into the flurbiprofen group (Group F,n =30) or the control group (Group C,n =30).HR,MAP and serum norepinephrine (NE),epinephrine (E) levels were measured at 30min before the end of operation (T0),immediately after the end of operation (T1),immediately after extubation (T2).Results The changes in MAP,HR and serum NE,E levels in Group F at T1 and T2 were less than those of Group C (all P ＜ 0.0 1).Conclusion Flurbiprofen axetil for preemptive analgesia may suppress the stress response during recovery period in neurosurgical patients,and keep the hemodynamic index stable. Key words: Flurbiprofen; Hemodynamic; Stress response; Preemptive analgesia; Neurosurgery

Effect of flurbiprofen axetil on perioperative plasma levels of prostaglandin E2 and β-endorphine in patients after remifentanil-based anesthesia

Objective To investigate the effect of flurbiprofen axetil on perioperative plasma levels of prostaglandin E2 (PGE2) and β-endorphine (β-EP) in patients after remifentanil-based anesthesia.Methods Sixty ASA Ⅱ patients of both sexes,aged 40-64 yr,weighing 50-75 kg,undergoing resection of esophageal cancer,were randomly divided into 3 groups (n =20 each):intralipid group (group A),flurbiprofen axetil pretreatment + postoperative analgesia with flurbiprofen axetil group (group B) and flurbiprofen axetil pretreatment group (group C).Anesthesia was induced with propofol,remifentanil and rocuronium and maintained with propofol,remifentanil and intermittent iv boluses of rocuronium.In group A,intralipid 0.2 ml/kg was injected intravenously at 30 min before operation and patient-controlled intravenous analgesia (PCIA) with fentanyl 15μg/kg + intralipid 0.2 ml/kg was used for postoperative analgesia.In group B,flurbiprofen axetil 2 mg/kg was injected intravenously at 30 min before operation and PCIA with fentanyl 15 μg/kg + flurbiprofen axetil 2 mg/kg was used for postoperative analgesia.In group C,flurbiprofen axetil 2 mg/kg was injected intravenously at 30 min before operation and PCIA with fentanyl 15 μg/kg + intralipid 0.2 ml/kg was used for postoperative analgesia.PCIA solution contained fentanyl 15 μg/kg,flurbiprofen axetil 2 mg/kg and intralipid 0.2 ml/kg in 100 ml of normal saline.The PCA pump was set up with a 0.5 ml bolus dose,a 10 min lockout interval and background infusion at a rate of 2 ml/h after a loading dose of 5 ml starting from 30 min before the end of operation.VAS score was maintained ＜ 3 after operation,and tramadol 50 mg was injected intravenously when VAS ≥ 4 after operation.The amount of remifentanil used during operation and the number of successfully delivered doses and the number of attempts,requirement for tramadol,apnea and severer hypotension were recorded within 48 h after operation.Blood samples were taken immediately before induction of anesthesia,at the end of operation,24 and 48 h after operation (T1-4) for determination of plasma β-EP and PGE2 concentrations.Results There was no significant difference in the amount of remifentanil used among the three groups (P ＞ 0.05).Compared with group A,the number of successfully delivered doses,the number of attempts and the requirement for tramadol were decreased,and the concentration of plasma PGE2 at T2,3 were significantly decreased in groups B and C,and the concentrations of plasma β-EP at T3,4 in group B and at T4 in group C were significantly increased (P ＜ 0.05).Compared with group B,the number of successfully delivered doses,the number of attempts and requirement for tramadol were significantly increased,and the concentration of plasma β-EP at T3,4 wassignificantly decreased in group C (P ＜ 0.05).Compared with the baseline value at T1,the concentrations of PGE2 were significantly increased at T2,3,and the concentration of plasma β-EP was significantly increased at T2,but decreased at T4 in group A,and the concentrations of β-EP at T3,4 were significantly increased in group B (P ＜ 0.05).There was no significant difference in the concentrations of PGE2 and β-EP between the four time points in group C (P ＞ 0.05).Apnea and severer hypotension were not found in the three groups.Conclusion The mechanism by which flurbiprofen axetil reduces postoperative opioid tolerance in patients after remifentanil-based anesthesia may be related to the decrease in PGE2 levels and increase in β-EP levels. Key words: Flurbiprofen ; Piperidines; Drug tolerance ; Dinoprostone ; beta-Endorphin

Effect of flurbiprofen axetil on lung ischemia-reperfusion injury in rats

Objective To investigate the effect of flurbiprofen axetil on lung ischemia-reperfusion(I/R) injury in rats.Methods Sixty healthy male SD rats weighing 250-300 g were randomly divided into 3 groups( n =20 each): group sham operation(group S) ;group I/R and group flurbiprofen axetil (group FA).The animals were anesthetized with intraperitoneal 2％ pentobarbital 50 mg/kg and tracheostomized and mechanically ventilated.Lung I/R was induced by 60 min occlusion of left hilus pulmonis followed by 120 min reperfusion.In FA group flurbiprofen axetil 10 mg/kg was injected iv at 15 min before occlusion of left hilus pulmonis.The rats were sacrificed at 120 min of reperfusion and then the lungs were removed for measurement of lung wet/dry weight ratio,apoptosis index,NF-κB activity,Bcl-2 and Bax protien expression,and microscopic examination.Bcl-2/Bax ratio was caculated.Results I/R significantly increased lung wet/dry weight ratio,apoptosis index,NF-κB activity,Bcl-2 and Bax protien expression,and decreased Bcl-2/Bax ratio.Flurbiprofen axetil preconditioning significantly attenuated the I/R-induced changes in lung wet/dry weight ratio,apoptosis index,NF-κB activity,Bcl-2 and Bax protien expression,and Bcl-2/Bax ratio in group FA as compared with group I/R.Flurbiprofen axetil preconditioning also ameliorated I/R-induced lung damage.Conclusion Flurbiprofen axetil can attenuate lung I/R injury in rats by inhibiting NF-κB activity,up-regulating Bcl-2 expression and down-regulating Bax expression and inhibiting apoptosis. Key words: Flurbiprofen; Reperfusion injury; Lung; Apoptosis

Effect of flurbiprofen axetil for postoperative patient-controlled intravenous analgesia in patients underwent laparoscopic surgery in treating women diseases

Objective To evaluate the effect and side effect of postoperative patient-controlled intravenous analgesia with flurbiprofen axetii in patients underwent laparoscopic surgery in treating women diseases. Methods 60 cases of such patients that should be ASA class Ⅰ or Ⅱ were randomly divided into two groups equally with 30 cases each. Fentanyl Group was given fentanyl 500 μg plus oudansetron 8 mg diluted to 100 ml via PCIA after surgery, flurbiprofen Group was administrated fentanyl 250 μg, and flurbiprofen axetil 100 mg plus ondansetron 8mg diluted 100ml via PCIA after surgery, the loading dose was flurbiprofen axetil 50 mg ten minutes prior to the end of the operates. The PCIA rate was 2 ml/h, blous 0.5 ml, lock time 15 min. Analgesia and sedation grade were accessed and side effects were recorded. Results There was no significant difference in analgesia and sedation grade between two groups. The side effects were lower in flurbiprofen Group than those in fentanyl Group. Conclusion Co-administration of flurbiprofen axetil by PCIA offers overall favorable analgesic responses as well as the reduction of fentanyl consumption during PCIA in the patients following laparoscopic surgery. Key words: Laparoacopic surgery in treating women diseases ; Fentanyl ; Flurbiprofen axetil; Analgesia