Effect Of Enteral Glutamine Research Articles

The effects of enteral glutamine on radiotherapy induced dermatitis in breast cancer

Radiotherapy is a critical component of breast cancer treatment. Many skin reactions ranging from erythema to moist desquamation and ulceration can be induced by high dose external beam radiotherapy. There is no golden standard for treating radiation dermatitis. Glutamine is an amino acid which improved wound healing through its anabolic effects and improvements in wound matrix formation in burn patients. We designed a study to show effects of glutamine in radiation induced dermatitis. Forty patients who received radiotherapy for breast cancer were randomized into 2 groups. In group 1 the patients were treated with 15 gr of enteral glutamine whereas the patients in group 2 were treated with placebo. The radiation induced skin reactions were evaluated in both groups. In glutamine treated group 88, 9% of patients developed grade I toxicity comparing to 80% of patients in placebo group developed grade II toxicity. This difference between the groups was statistically significant. (p<0.001) CONCLUSION: Enteral glutamine minimizes radiation induced dermatitis.

The effect of enteral glutamine on hepatic regeneration, hepatic functions and bacterial translocation in rats following partial hepatectomy

The effect of enteral glutamine on hepatic regeneration, hepatic functions and bacterial translocation in rats following partial hepatectomy

Effects of enteral glutamine on gut mucosal protein synthesis in healthy humans receiving glucocorticoids.

In hypercatabolic patients, the beneficial effects of glutamine on gut mucosa could be partly due to a stimulation of protein synthesis. The fractional synthesis rate (FSR) of gut mucosal protein was measured in four groups of healthy volunteers treated with glucocorticoids for 2 days. Two groups were studied in the postabsorptive state while receiving glutamine or a nitrogen equivalent (control) and two groups in the fed state with or without glutamine, using a 5-h intravenous infusion of [(13)C]leucine, [(2)H(5)]phenylalanine, and cortisone. After nutrient and tracer infusion, duodenal biopsies were taken. In the postabsorptive state, FSR of gut mucosal protein were 87 and 76%/day in the control group and 130% (P = 0.058 vs. control) and 104% (P = 0.17 vs. control)/day in the glutamine group, with leucine and phenylalanine as tracers, respectively. During feeding, FSR did not increase and no significant difference was observed between glutamine and control groups. Overall, FSR of the four groups were two- to threefold higher than those obtained previously in healthy humans, suggesting that glucocorticoids may increase gut mucosal protein synthesis. However, in this situation, a moderate enteral glutamine supply failed to demonstrate a significant effect on gut mucosal protein synthesis in the postabsorptive state and during feeding.

Effect of enteral glutamine on whole body leucine metabolism in vivo in humans

Effect of enteral glutamine on whole body leucine metabolism in vivo in humans

The effect of enteral glutamine and branched chain amino acids on the gut

The effect of enteral glutamine and branched chain amino acids on the gut