Effect Of Diabetes Mellitus Type Research Articles

The Effect of Diabetes Mellitus Type 1 on the Energy Metabolism of Hepatocytes: Multiphoton Microscopy and Fluorescence Lifetime Imaging

A decrease in the regenerative potential of the liver during the development of non-alcoholic fatty liver disease (NAFLD), which is observed in the vast majority of patients with diabetes mellitus type 1, significantly increases the risk of postoperative liver failure. In this regard, it is necessary to develop new approaches for the rapid intraoperative assessment of the condition of liver tissue in the presence of concomitant liver pathology. A modern label-free approach based on multiphoton microscopy, second harmonic generation (SHG), and fluorescence lifetime imaging microscopy (FLIM) allow for the evaluation of the structure of liver tissue as well as the assessment of the metabolic state of hepatocytes, even at the cellular level. We obtained optical criteria and identified specific changes in the metabolic state of hepatocytes for a reduced liver regenerative potential in the presence of induced diabetes mellitus type 1. The obtained criteria will expand the possibilities for the express assessment of the structural and functional state of liver tissue in clinical practice.

Type 2 diabetes mellitus and obesity: The synergistic effects on human locomotor function.

Diabetes Mellitus and obesity represent two chronic multifactorial conditions which may induce modifications in human motion strategy. Our study focused on gaining insight into biomechanical aspects of gait occurring in patients affected by both aforementioned pathologies. One hundred subjects were recruited and divided into four groups: 25 obese-diabetic patients with peripheral neuropathy; 25 obese non-diabetic patients; 25 non-obese diabetic patients with peripheral neuropathy; 25 healthy volunteers participated as a control group. Subjects performed 3-D Gait Analysis while walking barefoot at self-selected speed, performing three consecutive trials. A multivariate analysis of variance test was used to assess spatio-temporal and kinematic data difference in the four groups. Tukey's post-hoc adjustment was applied on multiple groups' comparison. Diabetic-obese subjects showed increased step width compared to controls, while step and stride length, and walking velocity were reduced. Interestingly, step width presented increased values even compared to diabetic patients. Kinematics data showed a significant reduction in ankle plantarflexion during the push-off phase of the gait cycle compared to controls, and to obese subjects. Furthermore, knee kinematics revealed a reduced peak flexion during the swing time of the gait cycle, compared to controls and diabetic subjects, which resulted in reduced knee dynamic excursion during normal walking compared to healthy subjects. Our data demonstrated that diabetic-obese subjects present gait features typical of both such pathologies. The specific impairment of ankle and knee joint kinematics provides evidence of a synergistic effect of Diabetes Mellitus type 2 and obesity on human ambulatory function.

The prognostic role of diabetes mellitus type 2 in the setting of hepatocellular carcinoma: a systematic review and meta-analysis

AimTo evaluate the effect of diabetes mellitus type 2 (T2DM) on the outcomes after treatment of hepatocellular carcinoma (HCC).MethodsPubMed and Cochrane Central Register of Controlled Trials Databases were systematically searched. Three HCC clinical outcomes were explored: death, progressive disease after locoregional therapies, and recurrence. Sub-analysis was performed according to the use of potentially curative (resection, transplantation, termo-ablation) or non-curative therapies. Odds ratios (OR) and 95% confidence intervals (CI) were calculated to compare the pooled data between T2DM and non-T2DM groups.ResultsA total of 27 studies were analyzed. Overall, 85.2% of articles were from Asia. T2MD was associated with an increased risk of death (OR 3.60; 95%CI 2.18-5.95; P < 0.001), irrespective of the treatment approach: curative (OR 1.30 95%CI 1.09-1.54; P = 0.003) or non-curative (OR 1.05; 95%CI 1.00-1.10; P = 0.045), increased HCC recurrence (OR 1.30; 95%CI 1.03-1.63; P = 0.03), and increased disease progressiveness (OR 1.24; 95%CI 1.09-1.41; P = 0.001).ConclusionsCurrent data provide strong evidence that T2DM unfavorably affects HCC progression and recurrence, and patients' survival after treatment, irrespective of the approach used.

Effect of diabetes mellitus type 2 induced high fat diet and STZ on spatial memory in adolescents the Sprague Dawley rat

Background and Aims: Subjects with type 2 diabetes mellitus in older adults have been reported to have decreased cognitive function but diabetes adolescents have received little attention. If the onset of the decline in cognitive or memory function occurs at a young age it will affect the productive age and have a detrimental effect on the quality of life. This study aims to determine the influence of type 2 diabetes mellitus on spatial memory in adolescent rats.

Structural and Biomechanical Corneal Differences between Type 2 Diabetic and Nondiabetic Patients.

Purpose To analyze and compare corneal structural and biomechanical properties, characterized by corneal hysteresis (CH) and resistance factor (CRF), between patients with and without type 2 diabetes mellitus (DM), and determine the main ocular variables that influence them. Methods Sixty diabetic and 48 age- and sex-matched non-DM patients were enrolled in this cross-sectional study. The DM group was analyzed according to DM duration (<or ≥ 10 years), HbA1c levels (<or ≥ 7%), and presence of retinopathy. CH and CRF were evaluated using the Ocular Response Analyzer® (ORA). Central corneal thickness (CCT) was determined by Scheimpflug tomography (Pentacam® HR). Intraocular pressure was obtained with ORA (IOPcc) and Goldmann applanation tonometry (IOP-GAT). Univariate and multivariate linear regression analyses were performed to evaluate the relationship between demographical, clinical, and ocular variables with the biomechanical properties. Results There were no statistically significant differences in the CH and the CRF between DM and non-DM groups (p=0.637 and p=0.439, respectively). Also, there was no statistical difference between groups for the CCT, IOPcc, or IOP-GAT. Multivariate linear regression analysis showed that CH was positively associated with CCT (p < 0.001) and negatively associated with IOPcc (p < 0.001), while CRF was positively associated with CCT (p < 0.001) and IOPcc (p=0.014). Conclusion The CCT and IOPcc were found to be the main parameters that affect corneal biomechanical properties both in diabetics and controls. In this study, there was no significant effect of DM type 2 on corneal biomechanics.

Effect of diabetes mellitus type 1 diagnosis on the corneal cell densities and nerve fibers.

Relation of diabetes mellitus (DM) to the various stages of corneal nerve fiber damage is well accepted. A possible association between changes in the cornea of diabetic patients and diabetic retinopathy (DR), DM duration, and age at the time of DM diagnosis were evaluated. The study included 60 patients with DM type 1 (DM1) and 20 healthy control subjects. The density of basal epithelial cells, keratocytes and endothelial cells, and the status of the subbasal nerve fibers were evaluated using in vivo corneal confocal microscopy. Basal epithelial cell density increased with age (p=0.026), while stromal and endothelial cell density decreased with age (p=0.003, p=0.0005, p<0.0001). After the DM1 diagnosis was established, this association with age weaken. We showed nerve fiber damage in DM1 patients (p<0.0001). The damage correlated with the degree of DR. DM1 patients with higher age at DM1 diagnosis had a higher nerve fiber density (p=0.0021). These results indicated that age at DM1 diagnosis potentially has an important effect on final nerve fiber and corneal cell density.

Effect of diabetes mellitus type 2 on salivary glucose, immunoglobulin A, total protein, and amylase levels in adults: A systematic review and meta-analysis of case-control studies.

Background:Saliva is a fluid with the complex compound which can be used as diagnostic markers for type 2 diabetes (T2D). This meta-analysis evaluated salivary glucose, immunoglobulin A (IgA), total protein, and amylase levels in adult T2D compared with the controls as well as the correlation of salivary glucose levels with serum glucose and hemoglobin A1C (HbA1c) levels in both groups.Materials and Methods:Web of Science, Scopus, PubMed, and Cochrane Library databases were searched up to July 2017. A random-effects analysis was performed using the mean difference (MD) and 95% confidence intervals. The search terms were “T2D, IgA, amylase, total protein, or glucose” combination with “saliva.” The studied variables were the sample size, the percentage of male, the mean age, the condition of saliva sampling, and the salivary levels of mentioned factors.Results:A total of 25 studies were included in this meta-analysis with 1432 and 900 diabetic patients and healthy controls, respectively. MD of salivary glucose level in patients with T2D, compared with the healthy controls, in fasting and nonfasting conditions were 6.23 mg/dL (P = 0.0002) and 6.70 mg/dL (P < 0.00001), respectively. Furthermore, the fasting salivary total protein in the patients was significantly higher than the controls (MD = 167.96 mg/dL; P = 0.03). Non-fasting salivary amylase and secretory IgA levels were significantly lower in the patients (MD = −48.61 IU/mL; P < 0.00001) than in the controls (MD = −9.42 IU/mL; P = 0.0006), respectively. The pooled estimate showed a significant correlation between salivary and serum glucose in the patients (r = 0.765; P < 0.001) and the controls (r = 0.646; P < 0.001) and between salivary glucose and serum glycated hemoglobin in the patients (r = 0.721; P < 0.001).Conclusion:Measurement of these salivary factors can be helpful for diagnostic and monitoring purposes of T2D. In addition, salivary glucose as a diagnostic tool can evaluate serum glucose and HbA1c levels in the diabetic patients.

MP13-14 STUDYING THE EFFECT OF DIABETES MELLITUS TYPE 2 ON PROSTATE RELATED PARAMETERS: A PROSPECTIVE SINGLE INSTITUTIONAL STUDY.

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology & Evaluation1 Apr 2017MP13-14 STUDYING THE EFFECT OF DIABETES MELLITUS TYPE 2 ON PROSTATE RELATED PARAMETERS: A PROSPECTIVE SINGLE INSTITUTIONAL STUDY. Ahmed Elabbady, Mohamed Mohieeldin Hashad, Ahmed Kotb, and Ali Ghanem Ahmed ElabbadyAhmed Elabbady More articles by this author , Mohamed Mohieeldin HashadMohamed Mohieeldin Hashad More articles by this author , Ahmed KotbAhmed Kotb More articles by this author , and Ali GhanemAli Ghanem More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.457AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Diabetes mellitus (DM) is a serious culprit of male health. A positive association exists between clinical markers of BPH and DM. The aim of this work is to examine the effects of type 2 diabetes mellitus (DM) on the variables associated with prostatic growth including serum PSA, serum testosterone and prostate volume and to correlate these variables with the duration of diabetic treatment. METHODS Our study was conducted over 3 months recruiting 501 men aged 55 years old or more, of which 207 patients had type 2 DM. Exclusion criteria were active urinary tract infection, suspicious rectal examination, urologic cancers, end organ damage and recent urologic manipulations. Serum PSA and serum testosterone were measured. Prostate volume was determined by abdominal ultrasonography using ellipsoid formula. This study was approved by the ethical committee and informed consents were obtained from participating patients. RESULTS The mean patient age was 60.21 ± 5.95 years. The mean PSA, Testosterone and prostate volume for diabetic men were 2.3 ng/ ml, 3 ng/ ml and 56 grams respectively. These were 3.5 ng/ ml, 4 ng/ ml and 51 grams respectively for non-diabetics. (p 0.001, p 0.001, p 0.03 respectively). The mean PSA density was 0.049 ± 0.043 ng/ml/cm3 in diabetics versus 0.080 ± 0.056 ng/ml/cm3 in non-diabetics (p<0.001). As high BMI in diabetic patients was a confounding factor, multiple regression analysis was done (table 1), confirming the true significant correlation of DM with the studied parameters. CONCLUSIONS Type 2 D.M is significantly associated with lower serum PSA, Testosterone and larger prostate volume. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e158-e159 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Ahmed Elabbady More articles by this author Mohamed Mohieeldin Hashad More articles by this author Ahmed Kotb More articles by this author Ali Ghanem More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

404 - Studying the effect of diabetes mellitus type 2 on prostate related parameters: A prospective single institutional study

404 - Studying the effect of diabetes mellitus type 2 on prostate related parameters: A prospective single institutional study

Auditory Temporal Resolution in Individuals with Diabetes Mellitus Type 2.

Introduction “Diabetes mellitus is a group of metabolic disorders characterized by elevated blood sugar and abnormalities in insulin secretion and action” (American Diabetes Association). Previous literature has reported connection between diabetes mellitus and hearing impairment. There is a dearth of literature on auditory temporal resolution ability in individuals with diabetes mellitus type 2. Objective The main objective of the present study was to assess auditory temporal resolution ability through GDT (Gap Detection Threshold) in individuals with diabetes mellitus type 2 with high frequency hearing loss. Methods Fifteen subjects with diabetes mellitus type 2 with high frequency hearing loss in the age range of 30 to 40 years participated in the study as the experimental group. Fifteen age-matched non-diabetic individuals with normal hearing served as the control group. We administered the Gap Detection Threshold (GDT) test to all participants to assess their temporal resolution ability. Result We used the independent t-test to compare between groups. Results showed that the diabetic group (experimental) performed significantly poorer compared with the non-diabetic group (control). Conclusion It is possible to conclude that widening of auditory filters and changes in the central auditory nervous system contributed to poorer performance for temporal resolution task (Gap Detection Threshold) in individuals with diabetes mellitus type 2. Findings of the present study revealed the deteriorating effect of diabetes mellitus type 2 at the central auditory processing level.

Additional Effect of Diabetes Mellitus Type 2 on the Risk of Coronary Artery Disease: Role of Serum Adiponectin

Background:Adiponectin, an adipocyte-derived hormone, is implicated in diabetes mellitus type 2 and atherosclerosis. The study was designed to investigate whether serum adiponectin levels in patients with both coronary artery disease (CAD) and diabetes mellitus type 2 (T2DM) are lower than in patients with CAD alone and control subjects.Objectives:In this present study, we measured serum adiponectin levels in consecutive CAD patients with and without T2DM and investigated whether decreased adiponectin is associated with risk factors of CAD.Materials and Methods:The study included 198 subjects, 138 patients with CAD (72 of whom had both CAD and T2DM), and 60 control subjects. We measured serum adiponectin, interleukin-6 (IL-6) and insulin by ELISA. In addition, Lipid profile, glucose and anthropometrical measurements were performed in all subjects.Results:The results revealed significant difference in serum adiponectin levels between patients with CAD+T2DM and patients with CAD alone (3.80 ± 1.52 vs. 5.25 ± 2.35, P = 0.007), between patients with CAD and control (5.25 ± 2.35 vs. 7.04 ± 3.32, P = 0.001), and between patients with CAD + T2DM and control (3.80 ± 1.52 vs. 7.04 ± 3.32, P < 0.001). Serum adiponectin level was significantly higher in women in contrast to men (5.97 ± 3.15 vs. 4.62 ± 2.81 µg/ml, P = 0.002). Serum adiponectin levels were correlated significantly with insulin (r = -0.178, P = 0.013), total cholesterol (r = -0.313, P < 0.001), low density lipoprotein (r = -0.154, P = 0.016), body mass index (r = -0.171, P = 0.016), glucose (r = -0.202, P = 0.006), HOMA-IR (r= -0.251, P = 0.001), and IL-6 levels (r = -0.321, P = 0.001). Adiponectin was correlated positively only with high density lipoprotein (r = 0.389, P < 0.001).Conclusions:It is speculated that increased insulin resistance and increase in other adipokines such as IL-6 may contribute to the decreased serum levels of adiponectin in patients with both CAD and T2DM.

Effect of Diabetes mellitus Type 2 on Pituitary Gland Hormones (FSH, LH) in Men and Women in Iraq

Effect of Diabetes mellitus Type 2 on Pituitary Gland Hormones (FSH, LH) in Men and Women in Iraq

Abstract P6-09-05: Insulin Resistance, Diabetes Mellitus and Breast Cancer Risk in Pre-and Postmenopausal Women: Modification Effect by Moderate Physical Activity

Abstract Background It has been hypothesized that diabetes may influence the risk of breast cancer (BC) by impaired regulation of the insulin and insulin-like growth factors (IGF) pathways. Current evidence supports a reduction in BC risk by doing regular physical activity due, in part, by reducing insulin resistance and improving glucose control. Material and Methods A population based case control study was conducted to evaluate the association between insulin resistance and diabetes mellitus on the risk of BC in Mexican women. A total of 1000 incident cases and 1074 matched controls to cases by five years of age, site and health institution were analyzed. Women provided information on health, diet and physical activity by means of a face to face interview; information about the family history of diabetes mellitus and whether or not women were diagnosed with this disease. Anthropometric measurements and blood samples were obtained from all women. A conditional logistic regression model was used to assess this association. Results In postmenopausal women, there was an interaction between physical activity and diabetes mellitus on the risk of BC. The effect of diabetes mellitus type 2 decreased with increasing moderate physical activity (OR = 3.67, 95% CI 1.78 — 7.58; OR = 2.86, 95% CI 1.37 — 5.96; OR = 0.82, 95% CI 0.19 — 3.59, by increasing tertiles of daily hours of moderate physical activity respectively); in premenopausal women, this association was not statistically significant (OR = 1.55, 95% CI 0.86-2.79), however in a subsample of premenopausal women, an increase was observed in the risk of BC per unit change in the increase of C-peptide, an indirect marker of insulin resistance (OR = 1.98, 95% CI 1.41 - 2.76). Discussion The results of this study are consistent with numerous mechanisms linking physical activity directly to reduce BC risk probably, in part, through reducing insulin resistance and improving glucose control. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P6-09-05.

Changes in the Internal Structure of the Human Crystalline Lens with Diabetes Mellitus Type 1 and Type 2

To investigate the effect of diabetes mellitus (DM) type 1 and type 2 on the internal structure of the lens. Observational cross-sectional study. One hundred seven patients with DM type 1, 106 patients with DM type 2, and 75 healthy control subjects. Scheimpflug photography was used to image the lens of the right eye of 213 patients with DM and 75 healthy control subjects. The densitogram of the Scheimpflug image was used to indicate the nucleus and the different layers of the cortex of the lens. Lenses with cataract were excluded. The size of the nucleus and the different layers of the cortex of the lens. The nucleus and the different cortical layers of the DM type 1 lenses were significantly thicker compared with those of the control group (P<0.001). A significant association was found between the duration of DM type 1 and both the anterior and posterior cortex, its different layers, and the nucleus (P<0.001). The increase in the anterior and posterior cortex with the duration of DM was comparable with that of the nucleus. No important differences in the internal structure of the lens were found between the patients with DM type 2 and the control group. Diabetes mellitus type 1 has a significant effect on the internal structure of the lens. The difference in effect of DM type 1 and type 2 on internal lens structure suggests an essential difference in pathogenesis. Furthermore, the results of the present study may indicate that the increase in the size of the lens with DM type 1 is the result of a generalized swelling of the lens, affecting all its different parts.

The effect of diabetes mellitus type 2, on endothelial function and inflammatory process in patients with coronary artery disease

The effect of diabetes mellitus type 2, on endothelial function and inflammatory process in patients with coronary artery disease

Adiponectin and Coronary Heart Disease: The Strong Heart Study

To the Editor: The adipocyte secreted protein, adiponectin, is of particular interest in metabolic and vascular disease because of its close associations with insulin sensitivity and obesity.1 Lower levels of adiponectin are associated with later development of type 2 diabetes.2 Recent observations from the Health Professionals Follow-Up Study3 suggest that lower adiponectin concentrations might also be associated with incident myocardial infarction, findings in keeping with prior observations in patients with end-stage renal failure.4 We examined prospective relationships of adiponectin to vascular disease in a case–control series selected from the Strong Heart Study (SHS). The SHS is the largest study of cardiovascular disease in American Indians, a group at particular risk of obesity and type 2 diabetes and in whom an increasing incidence of coronary heart disease (CHD) is seen.5 Cases and controls were selected from the SHS cohort.6 The SHS recruited 4549 volunteers of American Indian heritage from 3 geographic areas (Arizona, North and South Dakota, and Oklahoma).6 Volunteers (59% female) were invited to a study examination on three occasions (SH1, 1988 to 1992; SH2, 1993 to 1995; SH3, 1997 to 1999) and remained under continued surveillance for development of vascular disease as described previously.7,8 Because of availability of plasma samples, baseline data for this study were taken from the second examination (SH2), and participants with prevalent cardiovascular disease at SH2 (definite CHD and stroke), …