The work embodied in this paper presents the combined effects of Soret, chemical reaction, and Dufour on Couette flow in an irregular channel for dusty viscoelastic couple stress fluid. The behavior of the boundary layer is studied with the help of Brinkman-Forchheimer's extended Darcy model as a momentum equation for the unsteady, incompressible dusty viscoelastic fluid. The heat transfers are considered due to the radiation absorption parameter and Dufour effect, the mass transfer influenced by the chemical reaction, and the Soret effect. The boundary conditions of the problem and leading equations of the physical problem are solved by a similarity transformation, and the consequent ordinary linear differential equations are solved by the perturbation method. The obtained results are shown graphically. The computational results show a good agreement between our values and a particular case of the earlier work.