Topological states may be protected by a lattice symmetry in a class of topological semi-metals. In three spatial dimensions, the Berry flux around gapless excitations in momentum space defines a chirality concretely, so a protecting symmetry may be referred to as a chiral symmetry. Prime examples include Dirac semi-metal (DSM) in a distorted spinel, BiZnSiO$_4$, protected by a mirror symmetry and DSM in Na$_3$Bi, protected by a rotational symmetry. In these states, topology and a chiral symmetry are intrinsically tied. In this work, we investigate characteristics interplay between a chiral symmetry order parameter and instantaneous long-range Coulomb interaction with the standard renormalization group method. We show that a topological transition associated with a chiral symmetry is stable under the presence of the Coulomb interaction and the electron velocity always becomes faster than one of a chiral symmetry order parameter. Thus, the transition {\it must not} be relativistic, which implies a supersymmetry is intrinsically forbidden by the long-range Coulomb interaction. {Asymptotically exact} universal ratios of physical quantities such as energy gap ratio are obtained, and connections with experiments and recent theoretical proposals are also discussed.