Purpose This study aimed to determine how tongue and jaw displacement changes impact acoustic vowel contrast in talkers with amyotrophic lateral sclerosis (ALS) and controls. Method Ten talkers with ALS and 14 controls participated in this study. Loud, clear, and slow speech cues were used to elicit tongue and jaw kinematic as well as acoustic changes. Speech kinematics was recorded using three-dimensional articulography. Independent tongue and jaw displacements were extracted during the diphthong /ai/ in kite. Acoustic distance between diphthong onset and offset in Formant 1-Formant 2 vowel space indexed acoustic vowel contrast. Results In both groups, all three speech modifications elicited increases in jaw displacement (typical < slow < loud < clear). By contrast, only slow speech elicited significantly increased independent tongue displacement in the ALS group (typical = loud = clear < slow), whereas all three speech modifications elicited significantly increased independent tongue displacement in controls (typical < loud < clear = slow). Furthermore, acoustic vowel contrast significantly increased in response to clear and slow speech in the ALS group, whereas all three speech modifications elicited significant increases in acoustic vowel contrast in controls (typical < loud < slow < clear). Finally, only jaw displacements accounted for acoustic vowel contrast gains in the ALS group. In controls, however, independent tongue displacements accounted for increases in vowel acoustic contrast during loud and slow speech, whereas jaw and independent tongue displacements accounted equally for acoustic vowel contrast change during clear speech. Conclusion Kinematic findings suggest that slow speech may be better suited to target independent tongue displacements in talkers with ALS than clear and loud speech. However, given that gains in acoustic vowel contrast were comparable for slow and clear speech cues in these talkers, future research is needed to determine potential differential impacts of slow and clear speech on perceptual measures, such as intelligibility. Finally, findings suggest that acoustic vowel contrast gains are predominantly jaw driven in talkers with ALS. Therefore, the acoustic and perceptual consequences of direct instructions of enhanced jaw movements should be compared to cued speech modification, such as clear and slow speech in these talkers.