Effect Of Cinnamon Supplementation Research Articles

Effect of cinnamon supplementation on blood pressure, oxidative stress, and inflammatory biomarkers in adults: An umbrella review of the meta-analyses of randomized controlled trials

AimsCinnamon has positive effects on markers of cardiometabolic health, including blood pressure (BP), oxidative stress, and inflammation. Despite the evidence accumulated from meta-analysis studies on the effects of cinnamon on these markers, the reported findings are still controversial. This umbrella review was conducted to evaluate the evidence and provide a definitive clarification. Data synthesisWe conducted a systematic search in four scientific databases, including PubMed, Scopus, Web of Science, and Embase electronic databases, up to March 2024 to identify systematic reviews and meta-analyses of randomized clinical trials investigating the impact of cinnamon on blood pressure, oxidative stress, and inflammation. The findings revealed that cinnamon might exert favorable effects on systolic blood pressure (SBP) (ES = −2.36 mmHg; 95% CI: 3.86, −1.40), diastolic blood pressure (DBP) (ES = −1.65 mmHg; 95% CI: 2.41, −0.90), total antioxidant capacity (TAC) (WMD = 0.34; 95% CI: 0.04, 0.64), and interleukin-6 (IL-6) (WMD = −1.48; 95% CI: 2.96, −0.01). However, the results did not show any significant effect of cinnamon on malondialdehyde (MDA) (WMD = −0.47; 95% CI: 0.99, 0.05), C-reactive protein (CRP) (WMD = −1.33; 95% CI: 2.66, 0.00), and intercellular adhesion molecule 1 (ICAM-1) (WMD= 1.53, 95% CI: 12.03, 15.10). ConclusionsThe results of the studies included in this umbrella review support the usefulness of cinnamon consumption in modulating BP as well as improving TAC and IL-6 in metabolic disorders. Due to the limited number of studies, clinical diversity, and other limitations, more high-quality studies must be conducted to provide more precise and comprehensive recommendations. Registration numberPROSPERO, CRD42023487350.

The effect of cinnamon supplementation on eating disorder indices among people suffering from binge eating disorder: a randomized controlled trial

BackgroundBinge eating disorder is one of the main eating disorders that is characterized by recurrent binge eating episodes that lead to complications like high blood pressure, diabetes, dyslipidemia, etc. Many psychological and biological factors can lead to binge eating disorder and one of the main physiological reasons is insulin resistance. Cinnamon is an old favorite that has positive effects on insulin sensitivity. So, we examined the effect of cinnamon on binge eating disorder in this study.MethodsThis study was conducted on 40 binge eating disorder patients with a BMI between 25 and 39.9 kg/m2. They were divided into two groups one of them consumed 6 g of cinnamon per day while the other group consumed 6 g of white wheat as a placebo. Before and after the study we examined weight, height, Body Shape Questionnaire (BSQ), and Binge Eating Scale (BES) scale in all participants and did the statistical analysis.ResultsThere were no significant differences in baseline characteristics, gender, height, weight, BMI, education, and marriage status between the two groups. There were no significant changes between BSQ, BES, weight, and height after the study either.ConclusionAccording to our findings, although the weight of the patients in the cinnamon group decreased significantly, after the end of the study, no significant difference was observed in the weight, BMI, and BAS and BSQ indices between the two groups.Trial registrationThe study protocol was registered in the Iran Registry of Clinical Trials (IRCT) center (IRCT code: IRCT20090822002365N26, Registration date: 2021/11/7).

Effects of Cinnamon Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Since the effects of cinnamon supplementation on lipid profiles are still controversial, this study conducted a meta-analysis of randomized controlled trials to assess the effect of cinnamon supplementation on lipid profiles. The study was designed and conducted according to the guidelines of the 2020 preferred reporting items for systematic reviews and meta-analysis (PRISMA) statements. A systematic and comprehensive search was performed in several databases from inception up to 11 November 2023. The meta-analysis on the impact of Cinnamon on lipid profiles indicates a non-significant overall effect on low-density lipoprotein (weighted mean differences [WMD], -2.48; 95% confidence interval [CI], -9.70, 4.72). However, significant reductions are seen with doses < 500 mg/day (-10.26), and non-significant increases with doses ≥ 500 mg/day (1.18). The overall effect on high-density lipoprotein is non-significant (WMD, 3.97; 95% CI, -7.877, 15.831), showing varying responses at different doses. Triglycerides exhibit a significant overall reduction (WMD, -6.88; 95% CI, -12.62, -1.15), particularly in the < 500 mg/day group. The overall effect on cholesterol is non-significant (WMD, -4.314; 95% CI, -15.011, 6.384), with diverse responses at different doses. High heterogeneity underlines the importance of standardized study designs and further exploration of dosage-specific effects. Findings from this study suggest that cinnamon supplements might be beneficial to modulate the blood lipid profile.

Effect of cinnamon supplementation on the gut environment and ESR gene expression in the ovaries of laying quail

This study addressed the hypothesis that the inclusion of powdered cinnamon in a laying quail diet could increase the expression of genes related to the antioxidant defense systems in the intestine and improve the intestinal environment, thus promoting balance in the body. We used 144 laying quail (Coturnix japonica) distributed in a completely randomized design with two treatments: no supplementation of cinnamon (NSC) and supplementation of 9g/kg of cinnamon powder (CPS). At the end of the experimental period ovarian and duodenal tissues were collected for analysis of gene expression. Fragments of the central portions of the duodenum and jejunum were also collected for intestinal histological analysis. We observed a significant effect of the inclusion of cinnamon powder in the diet quail on the expression of the estrogen receptor alpha gene (P = 0.0004). The animals from the CPS treatment presented a higher height of villi and greater depth of crypts in the duodenum, and a higher height of villi and villus:cryptratio in the jejunum. The results show that cinnamon supplementation improves the integrity of intestinal tissue structures and development of the structures of the epithelium. Thus improves the productive performance of the birds.

Effects of cinnamon supplementation on systolic and diastolic blood pressure: a systematic review and meta-analysis of randomized controlled clinical trials

Introduction: Hypertension is a chronic condition that might lead to renal and cardiovascular diseases. The previous trials examining the effect of cinnamon supplementation on blood pressure have led to conflicting results. The present systematic review aimed to summarize the effect of cinnamon supplementation on blood pressure using a meta-analysis of published randomized controlled clinical trials.&#x0D; Methods: To identify the eligible articles, MEDLINE, SCOPUS, ISI Web of Science, and Google Scholar were searched from inception until September 2019 for relevant articles. The risk of bias assessment was performed using the Cochrane collaboration tool. A Random-effects model was applied to calculate the summary effects.&#x0D; Results: Totally, 11 trials with 686 participants were included in this systematic review and meta-analysis. The dose of cinnamon supplement consumption varied from 500 to 10000 mg/d. The meta-analysis revealed that cinnamon supplementation significantly decreases systolic blood pressure (SBP) [WMD (weighted mean difference)= -5.72 mmHg, 95% confidence interval (CI): -8.63 to -2.80; P&lt;0.001, I2= 81.1)] and diastolic blood pressure (DBP) (WMD= -4.06 mmHg, 95% CI: -6.68 to -1.44; P= 0.002, I2 = 88.6). Subgroup analysis suggested no significant reduction of DBP in subjects with diabetes (WMD= -2.015 mmHg, 95% CI: -4.55 to 0.52; P= 0.12, I2 = 72.3) and prediabetes or metabolic syndrome (WMD= -4.8 mmHg, 95% CI: -10.06 to 0.44; P= 0.073, I2= 92.5).&#x0D; Conclusions: Cinnamon supplementation could be beneficial in lowering SBP and DBP in adults. Further studies with different doses are recommended to confirm the present findings.

A Comparative study between Male and Female with Type 2 Diabetic based on the effect of cinnamon supplementation on fasting serum glucose, triglyceride, total cholesterol levels, and blood pressure

Objective: The objective of this study was to compare the effects of cinnamon on Fasting Serum glucose, triglyceride, total cholesterol levels and, Systolic and diastolic blood pressure (SBP and DBP) between men and women with type 2 diabetes.&#x0D; Methods: The 44 type 2 diabetic individuals were divided in 2 groups. Each group had 22 individuals and were randomly assigned to take either a cinnamon or a placebo capsule two times a day (2g/day) for 60 days in a double-blind study.&#x0D; Results: After 60 days, consumption 2 g/day of cinnamon reduced the mean fasting serum glucose to (– 11.7 % and – 35.5%), triglyceride (– 21.9 % and – 23.4%), total cholesterol (–31.52% and –24.29%), SBP (–10.86% and –17.7%) and DBP was reduced to (-4.1% and -0.22%) for female and male respectively.; no significant changes were noted in the placebo groups. There were changes at 60 days in fasting serum glucose and were significant (p&lt;0.05) for male comparing to female and there was significant (P&lt;0.05) effect of cinnamon doses on the concentration of cholesterol level in type 2 diabetic for female comparing to male.&#x0D; Conclusion: In the light of this research, it is recommended that individuals who have high fasting blood glucose, triglyceride, cholesterol and blood pressure levels should use cinnamon in their food preparations on regular basis.&#x0D; Key words: Cinnamon, Type 2 Diabetes, Fasting Serum Glucose, Diastolic Blood Pressure.&#x0D; &#x0D; الملخص&#x0D; هدفت هذه الدراسة إلى مقارنة تأثير القرفة على سكر الدم الصائم والدهون الثلاثية والكوليسترول وضغط الدم الانقباضي والانبساطي بين الذكور والإناث المصابين بمرض السكري نوع 2. شملت الدراسة 44 مريض سكري نوع 2 من كلا الجنسين (الذكور والإناث) وتم تقسيمهم إلى مجموعتين كل مجموعة مكونة من 22 شخص، تم تعيين الاختيار بشكل عشوائي إما كبسولات القرفة أو الدواء الوهمي لتناولها مرتين في اليوم (2جرام/يوم) لمدة 60 يوم في دراسة تامة التعشية. بعد 60 يوما من استهلاك 2 جرام من القرفة انخفضت نسبة سكر الدم الصائم إلى (-11.7% و -35.5%)، الدهون الثلاثية إلى (-21.9% و -23.4%), الكوليسترول إلى (-31.52% و -24.29%), ضغط الدم الانقباضي إلى (-10.68% و -17.7%), ضغط الدم الانبساطي إلى (-4.1% و -0.22%) للإناث والذكور على التوالي; ولا توجد فروق معنوية على مجموعة الدواء الوهمي.&#x0D; كانت هناك فروق معنوية (p&lt;0.05) للذكور مقارنة بالإناث عند استخدام القرفة لمدة 60 يوم في جلوكوز الدم الصائم وهناك أيضا فروق معنوية (p&lt;0.05) للإناث مقارنة بالذكور في مستوى الكوليسترول لمرضى السكري نوع 2. وعلى ضوء هذا البحث، يوصى الأشخاص الذين لديهم ارتفاع في سكر الدم الصائم والدهون الثلاثية والكوليسترول، باستخدام القرفة مع وجباتهم الغذائية بشكل منتظم.

The effect of cinnamon supplementation on glycemic control in women with polycystic ovary syndrome: A systematic review and meta-analysis.

Several clinical trials have identified glycemic-lowering effects of cinnamon, while other studies have reported conflicting findings. A comprehensive systematic search on Embase, PubMed, Scopus, Web of Science, and Cochrane Library was conducted using defined keywords in any language through June 2020. Studies that compared the effect of cinnamon with placebo on insulin resistance (IR) indices, as the primary outcome, in women with polycystic ovary syndrome (PCOS) were considered eligible. Standard Mean difference (SMD) (with 95% confidence intervals) for endpoints were calculated using the random-effects model. Finally, five RCTs which met the criteria were included in the meta-analysis. After pooling data, cinnamon supplementation significantly reduced homeostatic model assessment for insulin resistance (HOMA-IR) scores in women with PCOS (SMD: -0.84, 95% CI: -1.52, -0.16, p=.010). Cinnamon supplementation likely improves certain IR markers in patients with PCOS. PRACTICAL APPLICATIONS: There are controversies reports for cinnamon intake, which animal models have suggested that it decreases IR via promotion of insulin action, stimulating insulin signaling pathways, and enhancing insulin sensitivity. This study provides comprehensive information about the effect of cinnamon on insulin resistance (IR) indices in women with PCOS. In this regard, our results indicated that cinnamon supplementation significantly reduced homeostatic model assessment for insulin resistance (HOMA-IR) scores in women with PCOS. Therefore, consumption of cinnamon can be safe and this can be a useful recommendation for improving IR and promotion of healthy life which indeed are the potential or actual uses of this research.

Effect of cinnamon supplementation on blood glucose and lipid levels in type2 diabetic patients

This study was planned to investigate the effects of supplementation of cinnamon on fasting blood glucose levels and lipid profiles among type2 diabetic patients. 60 subjects with type 2 diabetes from both sexes (30 males and 30 females) were allocated to the intervention and control groups (30 individuals per group). The doses of 1.5 g of cinnamon were equally administered orally in the form of cinnamon powder into 500 mg per capsule with breakfast, lunch, and dinner for 60 days. Control group received capsules of containing placebo. Blood samples were obtained on the beginning day of the experiment and at the end of 60 days. The fasting blood glucose levels and lipid profiles including total cholesterol, LDL-C, HDL-C and triglycerides of types 2 subjects were measured. Fasting blood glucose levels and lipid profiles in intervention group were significantly lower than control group (p<0.05). The average of fasting blood glucose levels, total cholesterol, cholesterol LDL and triglyceride levels were decreased after consumption of cinnamon powder, significantly(p<0.05). We observed no significant changes in fasting blood glucose levels and lipid profiles after consumption of placebo in control group. Conclusion: This study showed that consumption of cinnamon supplementation may be useful in control and decreasing of fasting blood glucose levels and lipid profiles among type 2 diabetes individuals.