Effects Of Calcitonin Administration Research Articles

Effects of Calcitonin Administration on the Amount of Bone Formation After Sutural Expansion Using Micro-CT.

Calcitonin injections were used in this investigation to see whether they influenced the quantity of bone formation after a rabbit model was subjected to micro-computed tomography expansion. Research was conducted on a total of 16 white male rabbits. Randomly, 4 groups of 4 rabbits each had their bone-borne expanders triggered by the Hyrax appliances as follows: In the first group (the control), the expansion was (0.5) mm per day for 12 days. In the second group, the same expansion protocol was used with 3 subcutaneous injections of calcitonin). In the third group, the expansion was (2.5) mm per day for 7 days followed by (0.5) mm per day for 7 days. In the fourth group, the same expansion protocol was used with 3 subcutaneous injections of calcitonin. As a result, all groups had their Hyrax devices expanded by 6mm in total. Sutural separation and new bone growth were examined by micro-computed tomography after 6 weeks of retention. To end the experiment, the rabbits were given a high dosage of phenobarbitone (90mg/kg). In the calcitonin-receiving group, there was a significant increase in anterior and posterior sutural separation, when compared with non-calcitonin-receiving groups. In the (2.5) mm instant expansion protocol, there was a significant increase in anterior and posterior sutural separation, when compared with the (0.5) mm instant expansion protocol. Calcitonin and the instant expansion protocol enhance new bone formation in rabbits.

Effect of calcitonin administration in dialysis patients with low-turnover bone disease: S.Spaia, N. Askepidis,I.Tsouchnikas,M.Theodoridis,C.Katsinas,M.Touboura,G. Vayonas.Renal Department, 2NDHospital IKAThessaloniki-Greece

Effect of calcitonin administration in dialysis patients with low-turnover bone disease: S.Spaia, N. Askepidis,I.Tsouchnikas,M.Theodoridis,C.Katsinas,M.Touboura,G. Vayonas.Renal Department, 2NDHospital IKAThessaloniki-Greece

Effects of calcitonin administration on serum calcium and inorganic phosphate levels of the fish, Heteropneustes fossilis, maintained either in artificial freshwater, calcium‐rich freshwater, or calcium‐deficient freshwater

AbstractFreshwater catfish, Heteropneustes fossilis, were injected daily intraperitoneally either with vehicle (0.1 ml of 0.6% NaCl/100 g body wt) or calcitonin (0.5 MRC U/100 g body wt) and maintained either in artificial freshwater, calcium‐rich freshwater, or calcium‐deficient freshwater for 10 days. The blood samples were collected on days 1, 3, 5, and 10 after initiation of the experiment, and serum calcium and inorganic phosphate levels were analysed.(i) Artificial freshwater: There is no change in the serum calcium and inorganic phosphate levels of calcitonin‐injected fish.(ii) Calcium‐rich freshwater: In vehicle‐injected fish there is a progressive hypercalcemia from day 1 to day 5. On day 10 the value decreases but it is still hypercalcemic. No change has been noticed in the serum calcium level of calcitonin‐treated fish. In vehicle‐treated fish the serum inorganic phosphate level indicates a decrease on day 10. The serum inorganic phosphate level of calcitonin‐treated specimens exhibits no change.(iii) Calcium‐deficient freshwater: There is a progressive decrease from day 1 to day 3 in serum calcium level of vehicle‐injected fish. Thereafter, from day 5 the level increases thus resulting in hypercalcemia on day 10. Calcitonin treatment to the fish evokes a decrease in the serum calcium level from day 1 to day 3. Thereafter a significant hypercalcemia is recorded on day 5 and day 10. In vehicle‐injected fish the serum inorganic phosphate levels decrease from day 3 to day 5. However, the value increases on day 10. Serum inorganic phosphate level of calcitonin‐treated fish exhibits a decrease on day 1. Thereafter, it rises progressively from day 3 to day 10. © 1993 Wiley‐Liss, Inc.

Inhibitory effect of calcitonin on growth hormone and insulin secretion in man

The effect of calcitonin administration on basal and arginine-stimulated growth hormone and insulin plasma levels was investigated. The intramuscular injection of synthetic salmon calcitonin (100 U MRC) in five normal subjects produced a significant decrease ( p < 0.05) in insulin concentration. The same amount of calcitonin given 15 min before an arginine infusion test in seven normal subjects significantly reduced the response of growth hormone ( p < 0.025) and insulin ( p < 0.005) to the stimulus.