Effect Of Caffeine Citrate Research Articles

Effect of Caffeine Citrate with Aminophyline on Apoptosis and Respiratory Endothelial Cell Dysfunction in Premature Infants

Effect of Caffeine Citrate with Aminophyline on Apoptosis and Respiratory Endothelial Cell Dysfunction in Premature Infants

Effects of caffeine citrate on respiratory mechanics and pulmonary function during peri-extubation in premature infants with low body weight.

article: Effects of caffeine citrate on respiratory mechanics and pulmonary function during peri-extubation in premature infants with low body weight - Minerva Pediatrics 2022 August;74(4):493-5 - Minerva Medica - Journals

Comparison of the effects of caffeine citrate administering at different time on outcome and neuro-development of premature infants

Objective To investigate the effect of caffeine citrate administering at different time on outcome and neurodevelopment of premature infants. Methods A total of 113 preterm infants with gestational age less than 32 weeks and birth weight less than 1 500 g who were hospitalized and treated in the neonatal intensive care unit from January 2018 to June 2018 were enrolled.According to the time when caffeine citrate treatment was started, they were divided into early treatment group(≤1 days) with 53 infants and late treatment group(1 to 10 days) with 60 infants.A retrospective analysis was performed for their clinical data.The perinatal conditions, treatment process and clinical outcomes of the two groups were compared and the neurological development was followed up at 12 months old. Results Compared with the late treatment group, the early treatment group had a significantly shorter durations of mechanical ventilation time, oxygen therapy time, hospitalization days and a significantly lower incidence of bronchopulmonary dysplasia, patent ductus arteriosusand intraventricular hemorrhage or periventricular leukomalacia, and there were significant differences between two groups(P<0.05, respectively). The neonatal behavioral neurological assessment score in the early treatment group was higher than that in the late treatment group at 40 weeks of gestational age, and there was significant difference between two groups(P<0.05). The mental developmental index at 3 months of corrected age, the mental developmental index and psychomotor developmental index at 12 months were significantly better in the early treatment group than those in the late treatment group, and there were significant differences between two groups(P<0.05, respectively). Conclusion Early use of caffeine citrate can improve the outcome of premature infants and improve the prognosis of nervous system. Key words: Caffeine citrate; Premature infant; Very low birth weight infant; Neural development

枸橼酸咖啡因预防早产儿呼吸暂停的临床效果观察

枸橼酸咖啡因预防早产儿呼吸暂停的临床效果观察

Neuroprotection in newborns. Review of current evidence

Neonatal hypoxia / ischemia increases morbidity and mortality, influences the further development of the child. This review presents current evidence of the effect of some substances with supposedly neuroprotective properties on the outcomes of newborn with perinatal encephalopathy. The results of the different temperature regimes after intranatal asphyxia are discussed. In previous trials, the efficacy and safety of therapeutic hypothermi a has been proven. Its use is enshrined in international recommendations on cardiop ulmonary resuscitation. However, in recent studies, no difference in outcomes is observed with the use of therapeutic hypothermia in comparison with normothermia. Evidence of the effect on the further neurological development the use in the early neonatal period of recombinant human erythropoietin in neonates with perinatal asphyxia is presented. Based on the results of the first randomized controlled trial, the use of xenon in combination with hypothermia did not lead to better outcomes than hypothermia alone. Data are given on the effect of caffeine citrate on the further neurological devel opment of children who received a drug for the treatment of apnea of prematurity in the neonatal period.

Protective effect of caffeine citrate on neonatal rat brain white matter damage induced by infection

Objective To investigate the protective effect of caffeine citrate on white matter damage in 2-day-old neonatal rats induced by postnatal infection. Methods Forty-eight 2-day-old SD rats were randomly divided into the control group (group A, n=16), lipopolysaccharide(LPS) infection group (group B, n=16), and caffeine citrate intervention group (group C, n=16) according to the random table method.The newborn rats of group B and C were continuously injected LPS 0.6 mg/kg intraperitoneally for 5 days from 2 days old, and the newborn rats of group A were continuously injected by an equal volume of 9 g/L saline intraperitoneally.Group C was continuously injected by caffeine citrate 10 mg/kg intraperitoneally for 7 days from 4 days old; equal volume of 9 g/L saline was injected into group A and B for 7 days continuously.At 12 days old, 8 rats of each group were sacrificed randomly to evaluate the expression of myelin basic protein(MBP) subcortical white matter by immunohistochemical method.Both sides of hippocampus of the rest 8 rats of each group were taken out in ice surface rapidly.The left hippocampus was used to detect the expression of MBP and Caspase-3 by Western blot method, and the right hippocampus was used to evaluate the MBP and Caspase-3 protein level by quantitative real-time PCR(qPCR) method. Results The mean integral optical density (IOD) of subcortical MBP positive expression in group A, group B and group C were 132.64±1.94, 102.43±2.12, 114.25±2.04, and the difference was statistically significant among 3 groups (F=22.912, P<0.05). The relative expression levels of MBP mRNA of 3 groups in hippocampus were 0.79±0.01, 0.39±0.03, 0.55±0.02, and the difference was statistically significant among 3 groups (F=18.584, P<0.05). The relative expression levels of MBP protein of 3 groups in hippocampus were 0.64±0.03, 0.31±0.03, 0.51±0.05, and the difference was statistically significant among 3 groups (F=25.780, P<0.05). The relative expression levels of Caspase-3 mRNA of 3 groups in hippocampus were 0.34±0.02, 0.74±0.03, 0.57±0.04, and the difference was statistically significant among 3 groups (F=6.105, P<0.05). The relative expression of Caspase-3 protein of 3 groups in hippocampus were 0.11±0.03, 0.36±0.02, 0.23±0.03, and the difference was statistically significant among 3 groups (F=40.541, P<0.05). Conclusions Caffeine citrate has showed protective effect on white matter damage in neonatal rats of 2 days old induced by postnatal infection.The mechanism may be related to inhibition of inflammatory response and reducing apoptosis. Key words: Caffeine citrate; Lipopolysaccharide; Brain damage; SD rats

Implantation de la microflore intestinale et régulation de la translocation bactérienne sous l’effet d’un traitement au citrate de caféine chez le raton en période néonatale

To relieve respiratory problems such as apnea in newborns, caffeine citrate is the drug of choice because of its good tolerance and therapeutic index. However, its impact on the intestinal microbial ecosystem and on bacterial translocation in the neonatal period remains insufficiently investigated. Therefore, the objective of this study was to evaluate the effects of caffeine citrate on the establishment of the intestinal microflora and bacterial translocation in rats from birth to the 30th day of life. Newborn Wistar rats were divided into four groups of 14 animals, each subdivided into a control group receiving a placebo (12mL tap water/kg/day) and another treated with caffeine citrate (12mg/kg/day). The animals were nursed by their mothers and weighed daily. A group of 14 rats was killed at birth and after 10, 20, or 30 days of life. Organs in which translocation was assessed (liver, lungs, spleen, and kidneys) and various fragments of intestine (duodenum, jejunum, ileum, and colon) were surgically removed. The bacteriological analysis performed involved enumeration of the total microflora, staphylococci, enterobacteria, and lactobacilli. From the 10th day, caffeine was shown to significantly decrease the weight of treated animals as compared with controls (P<0.05). However, caffeine treatment did not drastically alter the kinetics of establishment of the intestinal microflora as only enterobacteria were found to be significantly lower in any intestinal segment of the treated group (P<0.05). Moreover, from the 20th day of life, caffeine citrate significantly downregulated bacterial translocation of both Gram-positive and -negative bacteria (P<0.05). This preliminary study on the effects of treatment with caffeine citrate may open opportunities in clinical pediatrics; the treatment will remain partially effective in preventing bacterial translocation in the neonatal period.

The effects of caffeine citrate and white noise on ear asymmetry in the detection of two clicks

When one or two clicks are presented monaurally with white noise in the contralateral ear, there is considerable decrement in detection of two clicks presented to the right ear but little change in detection for the left ear in comparison to the performance without contralateral noise. An inverted U function is obtained when performance is tested with placebo, 375 mg or 500 mg of caffeine citrate, for right and left ear, with and without white noise. The relative superiority of the right ear performance without caffeine citrate or white noise is significantly correlated with right ear decrement with caffeine citrate or white noise. Results are discussed with reference to “strenght of the nervous system”, arousal and differentiation of function of the right and left cerebral hemispheres.