Aims: This study explores the mentorship of Early Career Teachers (ECTs) and its impact on student success in Appalachia, Ohio, by systematically reviewing existing literature. The critical role of mentorship in the professional development and retention of ECTs in rural educational settings is examined. Conceptual Framework: Situated Learning Theory (SLT) was adopted to guide the investigation into the challenges faced by ECTs in rural Appalachia and the significance of structured mentorship programs. Methodology: This study employs a systematic literature review approach, analyzing findings from existing research on the mentorship of ECTs. A rigorous search, selection, and synthesis of relevant studies were conducted to identify key themes and patterns. Results: The study revealed significant challenges for ECTs in Appalachia, including professional isolation, lack of resources, and socio-economic barriers. Structured mentorship programs were found to be crucial in enhancing ECTs’ instructional practices, resilience, and professional growth. The bi-directional benefits of mentorship were highlighted, showing positive impacts on both teachers and students. Conclusion: Effective mentorship is essential for the retention and professional development of ECTs in rural Appalachia. Comprehensive mentorship programs can significantly improve educational outcomes, reduce teacher attrition, and foster a supportive learning environment. Educational leaders and policymakers should prioritize tailored mentorship programs to address the unique challenges of rural settings. Additionally, investing in professional development and increasing access to resources for ECTs are essential for their sustained success and resilience.