Ply wrinkles in CFRP laminates are common and can lead to significant failure in composite structures if not properly assessed during the design, manufacturing, and service phases. Evaluating wrinkle geometries can be difficult as they are influenced by multiple factors, such as asymmetry, wavelength, and amplitude, which impact the structure's mechanical performance. High-frequency eddy current testing has proven effective for detecting in-plane waviness and out-of-plane wrinkles. However, the complex nature of CFRP structures and electrical anisotropy may hinder the effectiveness of an eddy current in-line monitoring system if not taken into account. In this study, an advanced modelling approach is employed to simulate the structural variation of the conductivity tensor. A designated wrinkle area, characterized by reduced electrical conductivity, is integrated with structural modelling to replicate a realistic coupon sample containing a wrinkle defect. Four proposed configurations are used to virtually test the samples, and their detection capabilities are analyzed quantitatively.