Background: HIV/AIDS is a serious disease. It is continuing to grow rapidly and spread both in Vietnam and many countries around the world. Recent studies show that approximately 10% of patients with cardiovascular disease. Around the world there are many studies on morphology and left ventricular systolic function by echocardiography in heart disease. The research aimed to evaluate the left ventricular structure and systolic function by echocardiographic in HIV infected and AIDS patients. Objectives: To study of the left ventricular structure and systolic function by echocardiographic in HIV infected and AIDS patients (HIV/AIDS). Methods: The study was performed by cross sectional descriptive study, including 109 patients who had been diagnosed immunodeficiency syndrome - HIV / AIDS, ages 17-70 (63 males and 46 females) in Hospital of Tropical Diseases in Ho Chi Minh City. Results: The rate of heart disease seen in the study: pericardial effusion 2.70%, myocarditis 0.90%, endocarditis 0.90%, mitral valve disease 8.30% and impaired left ventricular systolic function 5.50%. Left ventricular ejection fraction (EF) was 61.31 ± 6.36% and fractional shortening (FS) was 36.90 ± 5.30%. There was a decline (p <0.05) in ejection fraction (EF) and fractional shortening (FS) from 62.42 ± 6.19 % and 37.85 ± 5.25 % in the group of HIV/AIDS patients with CD4 cell counts > 200/mm3 down to 58.51 ± 6.00 % and 34.48 ± 4.68 % in the group of HIV/AIDS patients with CD4 cell counts ≤ 200/mm3. Conclusions: AIDS patients may have a reduced systolic ventricular function and some cardiac complications. Key words: HIV/AIDS; Systolic function; echocardiography.