Objectives: This study aimed to assess the impact of a 20-week resistance training program on force–velocity (F-V) parameters using an isokinetic two-point method and comparing one-repetition maximum (1-RM) methods in novice lifters. Methods: Previously untrained individuals completed a supervised, three-session weekly resistance training program involving concentric, eccentric, and isometric phases, repeated every 2 to 4 weeks. Isokinetic dynamometry measured the strength of elbow flexors/extensors at 60°/s and 150°/s, and knee flexors/extensors at 60°/s and 240°/s at Baseline, 3 months, and 5 months. F-V parameters, including maximal theoretical force (F0) and the F-V slope, were calculated. Participants also performed 1-RM tests for the upper and lower limbs. Repeated measures ANOVA with effect size (η2 > 0.14 as large) was used to analyze changes in F-V parameters and repeated measures correlation was used to test their association with 1-RM outcomes. Results: Eighteen male participants (22.0 ± 3.4 years) were analyzed. F0 significantly increased for all muscle groups (η2 = 0.423 to 0.883) except elbow flexors. F-V slope significantly decreased (steeper) for knee extensors and flexors (η2 = 0.348 to 0.695). Knee extensors showed greater F0 gains and steeper F-V slopes than flexors (η2 = 0.398 to 0.686). F0 gains were associated with 1-RM changes (r = 0.38 to 0.83), while F-V slope changes correlated only with lower limb 1-RM (r = −0.37 to −0.68). Conclusions: The 20-week resistance training program significantly increased F0 and shifted the F-V profile towards a more “force-oriented” state in knee muscles. These changes correlated with improved 1-RM performance. Future studies should include longer follow-ups and control groups.
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