The West Bohemia and adjacent Vogtland are well known for quasi-periodical earthquake swarms persisting for centuries. The seismogenic area near Nový Kostel involved about 90 % of overall earthquake activity clustered here in space and time. The latest major earthquake swarm took place in August–September 2011. In 1994 and 1997, two minor earthquake swarms appeared in another location, near Lazy. Recently, the depth-recursive tomography yielded a velocity image with an improved resolution along the CEL09 refraction profile passing between these swarm areas. The resolution, achieved in the velocity image and its agreement with the inverse gravity modeling along the collateral 9HR reflection profile, enabled us to reveal the key structural background of these West Bohemia earthquake swarms. The CEL09 velocity image detected two deeply rooted high-velocity bodies adjacent to the Nový Kostel and Lazy focal zones. They correspond to two Variscan mafic intrusions influenced by the SE inclined slab of Saxothuringian crust that subducted beneath the Tepla-Barrandian terrane in the Devonian era. In their uppermost SE inclined parts, they roof both focal zones. The high P-wave velocities of 6,100–6,200 m/s, detected in both roofing caps, indicate their relative compactness and impermeability. The focal domains themselves are located in the almost gradient-free zones with the swarm foci spread near the axial planes of profound velocity depressions. The lower velocities of 5,950–6,050 m/s, observed in the upper parts of focal zones, are indicative of less compact rock complexes corrugated and tectonically disturbed by the SE bordering magma ascents. The high-velocity/high-density caps obviously seal the swarm focal domains because almost no magmatic fluids of mantle origin occur in the Nový Kostel and Lazy seismogenic areas of the West Bohemia/Vogtland territory, otherwise rich in the mantle-derived fluids. This supports the hypothesis of the fluid triggering of earthquake swarms. The sealed focal domains retain ascending magmatic fluids until their critical pressure and volumes accumulated cause rock micro-fractures perceived as single earthquake bursts. During a swarm period, the focal depths of these sequential events become shallower while their magnitudes grow. We assume that coalescence of the induced micro-fractures forms temporary permeability zones in the final swarm phase and the accumulated fluids release into the overburden via the adjacent fault systems. The fluid release usually occurs after the shallowest events with the strongest magnitudes ML > 3. The seasonal summer declines of hydrostatic pressure in the Cheb Basin aquifer system seem to facilitate and trigger the fluid escape as happened for the 2000, 2008, and 2011 earthquake swarms. The temporary fluid release, known as the valve-fault action, influences the surface aquifer systems in various manners. In particular, we found three quantities, the strain, mantle-derived 3He content in CO2 surface sources and ground water levels, which display a 3–5 months decline before and then a similar restoration after each peak earthquake during the swarm activities. The revealed structure features are particularly important since the main Nový Kostel earthquake swarm area is proposed as a site for the ICDP project, ‘Eger Rift Drilling’.