This study provides a comprehensive systematic review of innovations in earthquake-resistant building design, focusing on advancements in materials, technologies, and methodologies aimed at enhancing structural resilience. A total of 32 peer-reviewed articles were analyzed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The findings highlight the critical role of advanced materials such as fiber-reinforced polymers (FRPs) and shape memory alloys (SMAs) in improving seismic performance, particularly through enhanced energy dissipation and structural flexibility. Technological integrations like Building Information Modeling (BIM), artificial intelligence (AI), and structural health monitoring (SHM) systems were identified as transformative tools that optimize design processes, predict structural vulnerabilities, and enable real-time risk management. Advanced simulation techniques, including finite element analysis (FEA) and computational fluid dynamics (CFD), were shown to significantly improve the accuracy and efficiency of seismic design. Despite these innovations, challenges related to cost, regulatory inconsistencies, and limited access to cutting-edge technologies persist, particularly in developing regions. The study concludes that while these advancements have revolutionized earthquake-resistant design, further efforts are needed to address these barriers and promote global resilience to seismic hazards.