As the boundary thrust between India and Asia in southern Tibet, the Zhongba–Gyangze Thrust (ZGT) emplaced the Yarlung Zangbo Suture Zone (YZSZ) units in the hanging wall southward onto Tethyan Himalaya sequences (THS) of the northern Indian continental margin in the footwall. Detailed field investigation, electron backscatter diffraction (EBSD) analysis, detrital zircon U–Pb geochronology and 40Ar–39Ar thermochronology were conducted to understand the evolution of the ZGT in Sangsang area, central southern Tibet. The shear zone of ZGT is located within the sedimentary-matrix mélange of YZSZ that is mainly composed of matrix of blueschist with meta pelagic–hemipelagic siliceous and siliciclastic rocks and blocks of basalt, limestone and sandstone. Penetrative F1 foliation and kink band structure were recorded within the matrix both on outcrop and under microscope. Strong lattice preferred orientation (LPO) fabric initiated by the low-temperature (350−450°C) (010)[001] slip system was detected by EBSD in the sodic amphiboles of the blueschist. The 40Ar–39Ar ages of the phengites from blueschist and sericites from the phyllite in the shear zone indicate that the activity of ZGT occurred between 71 and 60Ma. In the THS, a newly documented younger unit preserving detrital zircons from the southern Asian margin lies above the Triassic–Cretaceous sequences that carries only detrital zircons from the Indian continent. This unit is dated to be ~61Ma by the detrital zircon ages, similar to the Sangdanlin Formation and representing the Yarlung Zangbo Foreland Basin (YZFB) system. The ZGT had probably been active due to the initial India–Asia collision and acted as the frontal thrust controlling the development of YZFB.