Early Stage Research Articles

Analysis of Research Publications on Leprosy Drugs Related Adverse Drug Reactions – A Scinetometric Study

Abstract: Leprosy is curable and can be treated with multidrug therapy in the early stages. As a result, we chose a Scientometrics evaluation of leprosy research guides on adverse drug reactions to better grasp the current popularity of drug-related responses. During the 2010-2021 a study with a total of 48 publications was selected. This study aims to analyze scientometric tools such as frequency distribution, percentage analysis, double-related growth rate, and interaction rate. During the study period, 7 (14.58%) study publications were submitted in 2018. The related growth rate is identified by decreasing trend and the double time is growing from 2010 to 2021. The 11 published study sizes (22.92%) were provided by top writers, the average Degree of Collaboration is 0.96, and 19 (39.58%) published research articles by headers. India is the largest supplier of 21 leprosy research publications (43.75%). As India is the most productive country in leprosy research, hence there are four out of the top five institutions that are from the Indian center that is listed among the most productive institutions.

Poly(I:C), chitosan oligosaccharide, and chitosan enhance inactivated GCRV vaccine potency in grass carp Ctenopharyngodon idella

Vaccination is the most promising strategy to combat infectious diseases. Vaccine adjuvants are considered as key components in modern vaccinology since they provide the necessary help in enhancing the immune responses. This study evaluated the protective effects of poly (I:C), chitosan oligosaccharides (COS) and chitosan as new adjuvants in enhancing immune response and inhibiting GCRV replication using inactivated GCRV vaccines. Complete Freund's adjuvant (CFA) was used as a control adjuvant, and the survival rate of each group of grass carp was assessed. The CiIgM protein levels in sera were obviously boosted and sustained by the three novel adjuvant supplies, examining by enzyme-linked immunosorbent assay (ELISA) and western blotting (WB) methods. Meanwhile, mRNA expression of CiIgM in spleen and head kidney were elevated, checking by real time quantitative RT-PCR (qRT-PCR) assays. The Th1, not Th2 type immune responses, pro-inflammation cytokines and innate antiviral genes were also reinforced in spleen and head kidney tissues at early stages. The GCRV replication was significantly reduced post GCRV injection. The tissue sectioning showed a significant reduction in tissue damage in muscles, intestines, and hepatopancreatic tissues under the protection of the three adjuvants. The results indicated that poly(I:C), COS and chitosan can serve as novel and efficient adjuvants in inactivated vaccine in grass carp.

An Updated Review on Molecular Biomarkers in Diagnosis and Therapy of Colorectal Cancer.

Colorectal cancer is one of the most common cancer types worldwide. Since colorectal cancer takes time to develop, its incidence and mortality can be treated effectively if it is detected in its early stages. As a result, non-invasive or invasive biomarkers play an essential role in the early diagnosis of colorectal cancer. Many experimental studies have been carried out to assess genetic, epigenetic, or protein markers in feces, serum, and tissue. It may be possible to find biomarkers that will help with the diagnosis of colorectal cancer by identifying the genes, RNAs, and/or proteins indicative of cancer growth. Recent advancements in the molecular subtypes of colorectal cancer, DNA methylation, microRNAs, long noncoding RNAs, exosomes, and their involvement in colorectal cancer have led to the discovery of numerous new colorectal cancer biomarkers. In small-scale investigations, most biomarkers appear promising. However, large-scale clinical trials are required to validate their effectiveness before routine clinical implementation. Hence, this review focuses on small-scale investigations and results of big data analysis that may provide an overview of the biomarkers for the diagnosis, therapy, and prognosis of colorectal cancer.

Myelodysplastic Syndrome Related to Successful Treatment With177Lu-PSMA for Metastatic Castration-Refractory Prostate Cancer.

177Lu-vipivotide tetraxetan (177Lu-PSMA-617/LuPSMA) received recent EMA approval for metastatic castration-resistant prostate cancer, with promising data for earlier stages. Secondary myeloid neoplasm following exposure to DNA-damaging therapy (therapy-related myelodysplastic syndrome [MDS]) is a rare severe complication of 177Lu-oxodotreotide. We present a 77-year-old man, with synchronous liver, bone, and lymph node metastatic prostate cancer, having developed a low-risk MDS with SF3B1 mutation, 1 month after the sixth administration of LuPSMA. Although on partial metabolic and biological response with PSA nadir at 7 months after therapy, life quality was significantly altered by MDS.

Early Marine Systems' Design – Cracking the wicked problem - The case of a novel biomass harvesting vessel

Several IMDC contributions have argued for a better approach to capture stakeholders' expectations in vessel newbuilding projects' execution. The appropriate processes of requirements elucidation are, however, often forgotten or insufficiently handled in traditional ship design and customer-designer settings. Such situations most often reveal a situation in which both "tamed" and "wicked" problems are addressed and must be dealt with properly and effectively at the earliest stage of the process. This paper shows how such problems can be addressed by using the existing multidisciplinary methodology. A practical approach consisting of a set of methods, tools, and work processes integrated into the Accelerated Business Development (ABD) approach is applied to a specific use case, a next-generation factory stern trawler development. A detailed step-by-step story of the early vessel design process – requirements elucidation in parallel with concept design solution development – is outlined following a narrative approach. The process being described covers how necessary support information, stakeholders' expectations identification, business[1]related analyses, specific design layout, onboard comfort, and fish process handling and storage are dealt with effectively and efficiently. This case study exemplifies specific solutions to better handle particularly wicked problem situations, but also tamed problems are addressed systemically. The paper concludes by showing how a final ship design solution can look like and consequently be prepared for and to be built. The handover process and documentation from requirements capture and concept design solution development to further basic design activities are highlighted. The case vessel at hand won the prestigious “ship-of-the-year” award in Norway in 2023. The paper critically discusses what are likely to be the most important factors leading to this outcome.

PSYCHOLOGICAL CHARACTERISTICS OF EMERGING ADULTS – STUDENTS OF HIGHER EDUCATIONAL INSTITUTIONS

Introduction. At present, understanding the psychological and social aspects of personality development among adolescents aged 17-21 is crucial. By this age, most have completed secondary education, with many continuing their studies at higher educational institutions. However, junior students often face challenges related to psychological maturity, readiness for independent work, and adaptation to the academic environment, leading to maladaptation and stress resistance issues. This study aims to investigate the key psychological characteristics of older adolescents to enhance their effectiveness in higher education. Materials and Methods. A thorough analysis of the main psychological traits of older adolescents in higher educational institutions was conducted based on data from recent domestic and international literature. Results. This study identified several psychological factors that influence the academic productivity and adaptation of older adolescent students in higher education. Some factors contribute to their success, such as adaptability to new social groups and recognition by peers and faculty. However, other factors can hinder or even prevent these processes for certain groups of students. Conclusion. Older adolescents demonstrate a deepening of their individual development compared to earlier stages. However, first-year students often exhibit traits of psychological immaturity and partial instability. Understanding these psychological characteristics is essential for effectively supporting and guiding older adolescents in their educational journey.

Unveiling the role of interleukin-6 in pancreatic cancer occurrence and progression

Pancreatic cancer is difficult to diagnose early and progresses rapidly. Researchers have found that a cytokine called Interleukin-6 (IL-6) is involved in the entire course of pancreatic cancer, promoting its occurrence and development. From the earliest stages of pancreatic intraepithelial neoplasia to the invasion and metastasis of pancreatic cancer cells and the appearance of tumor cachexia, IL-6 drives oncogenic signal transduction pathways and immune escape that accelerate disease progression. IL-6 is considered a biomarker for pancreatic cancer diagnosis and prognosis, as well as a potential target for treatment. IL-6 antibodies are currently being explored as a hot topic in oncology. This article aims to systematically explain how IL-6 induces the deterioration of normal pancreatic cells, with the goal of finding a breakthrough in pancreatic cancer diagnosis and treatment.

P25 Identification of early changes in extracellular microRNA biomarkers of scleroderma for point-of-care diagnosis

Abstract Introduction and aims Scleroderma is a rare autoimmune disease, characterized by excessive extracellular matrix deposition leading to chronic inflammation and fibrosis. As a progressive disease initially affecting the skin, it presents similarly to Raynaud phenomenon, which delays diagnosis and treatment. Clinical diagnostic tests lack sensitivity, therefore novel Methods of detection and sensitive biomarkers are required to improve diagnosis rates. MicroRNAs are short, stable, noncoding RNAs, often present in the extracellular space, and can be sampled from interstitial skin fluid (ISF) through the employment of hydrogel microneedles. We aim to use this technique to improve upon current clinical gold standards of diagnosing scleroderma, at earlier stages of the disease. Methods In this study, we performed next-generation small-RNA sequencing on ISF from healthy individuals, patients prior to a clinical diagnosis of scleroderma [termed very early detection of systemic sclerosis (VEDOSS)], and patients with scleroderma classified as low and high skin score, identifying a panel of microRNA biomarkers for scleroderma diagnosis. Swellable hydrogel microneedles were manufactured in house, applied to excised human tissue and preclinical mouse models to demonstrate the ability to access and quantify extracellular microRNAs in ISF. Results Patients who received a VEDOSS diagnosis have increased ISF abundance of miR-379-5p and miR-125a-5p and decreased miR-30e-3p compared with healthy patients. miR-379-5p, miR-363-3p and miR-221-3p are sensitive to the progression of scleroderma and could be used to track the disease with improved sensitivity to autoantibodies in blood or where clinical practices usually require a skin biopsy. Using preclinical models of skin disease, we could differentiate between conditions, with higher sensitivity than blood sampling using our microneedle technology. Conclusions By identifying extracellular mircoRNAs, we have shown the potential use of these sensitive biomarkers in a liquid biopsy that can be applied at point-of-care. Peptide nucleic acids complementary to our microRNA biomarkers, will be used to provide real-time on-the-chip readouts of these ­biomarkers.

Advances in Mapping Lowermost Mantle Convective Flow With Seismic Anisotropy Observations

AbstractConvective flow in the deep mantle controls Earth's dynamic evolution, influences plate tectonics, and has shaped Earth's current surface features. Present and past convection‐induced deformation manifests itself in seismic anisotropy, which is particularly strong in the mantle's uppermost and lowermost portions. While the general patterns of seismic anisotropy have been mapped for the upper mantle, anisotropy in the lowermost mantle (called D′′) is at an earlier stage of exploration. Here we review recent progress in methods to measure and interpret D′′ anisotropy. Our understanding of the limitations of existing methods and the development of new measurement strategies have been aided enormously by the availability of high‐performance computing resources. We give an overview of how measurements of seismic anisotropy can help constrain the mineralogy and fabric of the deep mantle. Specifically, new and creative strategies that combine multiple types of observations provide much tighter constraints on the geometry of anisotropy than have previously been possible. We also discuss how deep mantle seismic anisotropy provides insights into lowermost mantle dynamics. We summarize what we have learned so far from measurements of D′′ anisotropy, how inferences of lowermost mantle flow from measurements of seismic anisotropy relate to geodynamic models of mantle flow, and what challenges we face going forward. Finally, we discuss some of the important unsolved problems related to the dynamics of the lowermost mantle that can be elucidated in the future by combining observations of seismic anisotropy with geodynamic predictions of lowermost mantle flow.

Estimation of potential carbon sequestration in Thai reforestation from mining, based on the integrated spatial analysis

Mining, an activity that dates to the earliest stages of human civilization, has played a vital role in fulfilling human requirements for an extended period of time. Nevertheless, it is worth noting that this particular activity accounts for a significant proportion, ranging from 4% to 7% of the overall world greenhouse gas emissions. These emissions mostly consist of carbon dioxide, methane, and nitrogen oxides, which are released because of fuel burning, on-site energy generation, and many other sources. The mining industry, as a constituent of industrial process and product use (IPPU) sector in Thailand, makes a substantial contribution to these emissions. Thailand is now engaged in the implementation of carbon sequestration strategies, specifically focusing on the reclamation and replanting of post-mining zones. This initiative aims to tackle the various issues associated with small-scale operations within the country’s mining sector. The objective of this study is to analyse the carbon sequestration potential of Thailand’s mining area through the utilization of satellite pictures obtained from LANDSAT 8 OLI and Geographic Information System (GIS) applications. This study assesses the present carbon storage capacity, establishes the appropriate carbon pricing, and investigates the potential for reforestation in mining areas inside the nation. Based on the findings, it is evident that the northern region of Thailand has the most substantial potential for carbon sequestration, mostly due to the presence of vegetated land. Furthermore, it is projected that the overall carbon sequestration capacity in Thailand will amount to 14.68 MtCO2e in 2023 and 28.02 MtCO2e in 2030.

Approaches and considerations in the endoscopic treatment of T1 colorectal cancer.

The detection of early colorectal cancer (CRC) is increasing through the implementation of screening programs. This increased detection enhances the likelihood of minimally invasive surgery and significantly lowers the risk of recurrence, thereby improving patient survival and reducing mortality rates. T1 CRC, the earliest stage, is treated endoscopically in cases with a low risk of lymph node metastasis (LNM). The advantages of endoscopic treatment compared with surgery include minimal invasiveness and limited tissue disruption, which reduce morbidity and mortality, preserve bowel function to avoid colectomy, accelerate recovery, and improve cost-effectiveness. However, T1 CRC has a risk of LNM. Thus, selection of the appropriate treatment between endoscopic treatment and surgery, while avoiding overtreatment, is challenging considering the potential for complete resection, LNM, and recurrence risk.

Preferences of physicians for treatment-related toxicity vs. recurrence in melanoma (GERMELATOX-A): the doctors’ perspective

IntroductionAdjuvant treatment with immune checkpoint inhibitors, such as PD1-antibodies (ICI) ± CTLA4-antibodies (cICI) or targeted therapy with BRAF/MEK inhibitors (TT), has shown a significant improvement in disease-free survival (DFS) for high-risk melanoma patients. However, due to specific side effects, the choice of treatment is often influenced by the risk of toxicity. Therefore, the role of physicians in treatment decisions of patients is crucial. This study investigated for the first time in a multicenter setting the attitudes and preferences of dermatooncologists in Germany and Switzerland regarding adjuvant treatment with (c)ICI and TT.MethodsIn the GERMELATOX-A study, 108 physicians (median age: 32 yrs, 67.6% female) from 11 skin cancer centers were surveyed to rate typical side effect scenarios of (c)ICI and TT treatments and then compared to patients’ ratings evaluated in a previous analysis from the same centers. The scenarios described mild-to-moderate or severe toxicity and included melanoma relapse leading to death. The physicians were asked about the level of side effects they would tolerate in exchange for a reduction in melanoma relapse and an increase in survival at 5 years.ResultsThe preferences of physicians and patients revealed significant differences regarding adjuvant melanoma treatment with (c)ICI and TT (p < 0.05). Compared to patients, physicians tend to value a melanoma relapse less severe, according to a visual analog scale. They were also less threatened by all scenarios of side effects during adjuvant treatment with (c)ICI or TT, compared to patients. Physicians required lower risk reductions for disease-free survival (DFS) and overall survival (OS) for both ICI and TT and their drug-related side effects to accept these treatments. In case of severe side effects, physicians required similar 5-year DFS rates for ICI and TT (60–65%), while patients needed a 15% improvement of 5-year DFS for ICI compared to TT (80%/65%). For survival, physicians expected an OS improvement of + 10% for all three treatment modalities, whereas patients required a higher increase: + 18–22% for ICI and + 15% for TT.ConclusionOur study highlights the importance of understanding the patient’s perspective and a potential difference to the doctor’s view when making decisions about adjuvant melanoma treatment with (c)ICI and TT, especially as these treatments are increasingly being implemented in earlier stages.

EfficientTrain++: Generalized Curriculum Learning for Efficient Visual Backbone Training.

The superior performance of modern computer vision backbones (e.g., vision Transformers learned on ImageNet-1K/22K) usually comes with a costly training procedure. This study contributes to this issue by generalizing the idea of curriculum learning beyond its original formulation, i.e., training models using easier-to-harder data. Specifically, we reformulate the training curriculum as a soft-selection function, which uncovers progressively more difficult patterns within each example during training, instead of performing easier-to-harder sample selection. Our work is inspired by an intriguing observation on the learning dynamics of visual backbones: during the earlier stages of training, the model predominantly learns to recognize some 'easier-to-learn' discriminative patterns in the data. These patterns, when observed through frequency and spatial domains, incorporate lower-frequency components, and the natural image contents without distortion or data augmentation. Motivated by these findings, we propose a curriculum where the model always leverages all the training data at every learning stage, yet the exposure to the 'easier-to-learn' patterns of each example is initiated first, with harder patterns gradually introduced as training progresses. To implement this idea in a computationally efficient way, we introduce a cropping operation in the Fourier spectrum of the inputs, enabling the model to learn from only the lower-frequency components. Then we show that exposing the contents of natural images can be readily achieved by modulating the intensity of data augmentation. Finally, we integrate these two aspects and design curriculum learning schedules by proposing tailored searching algorithms. Moreover, we present useful techniques for deploying our approach efficiently in challenging practical scenarios, such as large-scale parallel training, and limited input/output or data pre-processing speed. The resulting method, EfficientTrain++, is simple, general, yet surprisingly effective. As an off-the-shelf approach, it reduces the training time of various popular models (e.g., ResNet, ConvNeXt, DeiT, PVT, Swin, CSWin, and CAFormer) by [Formula: see text] on ImageNet-1K/22K without sacrificing accuracy. It also demonstrates efficacy in self-supervised learning (e.g., MAE). Code is available at: https://github.com/LeapLabTHU/EfficientTrain.

The health-related quality of life of early-onset colorectal cancer patients: an Australian cross-sectional study.

Early-onset colorectal cancer (EOCRC) patients are more likely to have advanced disease and undergo more aggressive treatment modalities. However, current literature investigating the health-related quality of life (HRQoL) of EOCRC patients is scarce. This study aimed to determine the HRQoL of an Australian cohort of EOCRC patients including a subset who underwent pelvic exenteration (PE) or cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). A cross-sectional study of EOCRC patients treated at the Royal Prince Alfred Hospital, Sydney Australia was performed. Patients were divided into groups based on the time interval from their index operation: ≤2 years and >2 years. HRQoL was evaluated using the SF-36v2 questionnaire. A total of 50 patients were included. For patients ≤2 years from surgery, the median physical component summary (PCS) and mental health component summary (MCS) scores were 53.3 (36.4-58.9) and 47.3 (37.5-55.7). In the >2 years group, the median PCS and MCS scores were 50.6 (43.3-57.7) and 50.2 (39.04-56.2), respectively. Stage I (vs. stage II) disease and emergency (vs. elective) surgery conferred poorer PCS scores in patients ≤2 years from surgery. No other variables impacted PCS or MCS scores in EOCRC patients in either group. HRQoL of EOCRC patients was equivocal to the Australian population. Having an earlier stage of diagnosis and emergency index operation was associated with poorer levels of physical functioning in patients ≤2 years from surgery. However, because of the limitations of this study, these findings require validation in future large-scale prospective research.

Effects of non-ionizing radio frequency electromagnetic radiation on the development and behavior of early embryos of Danio rerio

ABSTRACT Biological effects of radio frequency electromagnetic radiation (RF-EMR) in the range of 900–1800 MHz emerging from the mobile phone were investigated and were found to influence the locomotor pattern when exposure was initiated from 1 hour post fertilization (hpf) in zebrafish embryos (ZE), Danio rerio. Mobile phones and other wireless devices offer tremendous advantages. However, on the flipside they are leading to an increased electromagnetic energy in the environment, an excess of which could be termed as electromagnetic pollution. Herein, we tried to understand the effects of RF-EMR emerging from the mobile phone, on the development and behavior of ZE, exposed to RF-EMR (specific absorption rate of 1.13 W/kg and 1800 MHz frequency) 1 hr daily, for 5 days. To understand if there could be any developmental stage-specific vulnerability to RF-EMR, the exposure was initiated at three different time points: 1hpf, 6hpf and 24hpf of ZE development. Observations revealed no significant changes in the survival rate, morphology, oxidative stress or cortisol levels. However, statistically significant variations were observed in the batch where exposure started at 1hpf, with respect to locomotion patterns (distance travelled: 659.1 ± 173.1 mm Vs 963.5 ± 200.4 mm), which could be correlated to anxiety-like behavior; along with a corresponding increase in yolk consumption (yolk sac area: 0.251 ± 0.019 mm2 Vs 0.225 ± 0.018 mm2). Therefore, we conclude that RF-EMR exposure influences the organism maximally during the earliest stage of development, and we also believe that an increase in the time of exposure (corresponding to the patterns of current usage of mobile phones) might reveal added afflictions.

Transscleral ciliary surgery in glaucoma:from destructive surgery to minimally invasive surgery

Over the years, there has been significant advancement in the safety and effectiveness of external cyclosurgery for glaucoma. This progress ranges from the initial "cyclodestructive surgery" to modern cycloplasty techniques, expanding beyond end-stage glaucoma treatment. Notably, innovative approaches like micropulse transscleral cycloplasty and ultrasonic cycloplasty are now being employed in earlier stages of glaucoma with better visual acuity, qualifying as minimally invasive procedures. Through a comprehensive review of the historical evolution of external cyclosurgery, elucidation of the mechanisms, clinical outcomes, and potential complications associated with novel cycloplasty techniques, and integration of practical clinical insights, this article aims to furnish clinicians with a profound comprehension of external cyclosurgery for glaucoma.

Lung cancer detection based on computed tomography image using convolutional neural networks.

Lung cancer is the most common type of cancer, accounting for 12.8% of cancer cases worldwide. As initially non-specific symptoms occur, it is difficult to diagnose in the early stages. Image processing techniques developed using machine learning methods have played a crucial role in the development of decision support systems. This study aimed to classify benign and malignant lung lesions with a deep learning approach and convolutional neural networks (CNNs). The image dataset includes 4459 Computed tomography (CT) scans (benign, 2242; malignant, 2217). The research type was retrospective; the case-control analysis. A method based on GoogLeNet architecture, which is one of the deep learning approaches, was used to make maximum inference on images and minimize manual control. The dataset used to develop the CNNs model is included in the training (3567) and testing (892) datasets. The model's highest accuracy rate in the training phase was estimated as 0.98. According to accuracy, sensitivity, specificity, positive predictive value, and negative predictive values of testing data, the highest classification performance ratio was positive predictive value with 0.984. The deep learning methods are beneficial in the diagnosis and classification of lung cancer through computed tomography images.

Identification of potential hub genes and regulatory networks of smoking-related endothelial dysfunction in atherosclerosis using bioinformatics analysis.

Endothelial dysfunction, the earliest stage of atherosclerosis, can be caused by smoking, but its molecular mechanism requires further investigation. This study aimed to use bioinformatics analysis to identify potential mechanisms involved in smoking-related atherosclerotic endothelial dysfunction. The transcriptome data used for this bioinformatics analysis were obtained from the Gene Expression Omnibus (GEO) database. The GSE137578 and GSE141136 datasets were used to identify common differentially expressed genes (co-DEGs) in endothelial cells treated with oxidized low-density lipoprotein (ox-LDL) and tobacco. The co-DEGs were annotated using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomics (KEGG) databases. Additionally, a protein-protein interaction (PPI) network was constructed to visualize their interactions and screen for hub genes. GSE120521 dataset was used to verify the expression of hub genes in unstable plaques. The miRNA expression profile GSE137580 and online databases (starBase 2.0, TargetScan 8.0 and DGIdb v4.2.0) were used to predict the related non-coding RNAs and drugs. A total of 232 co-DEGs were identified, including 113 up-regulated genes and 119 down-regulated genes. These DEGs were primarily enriched in detrimental autophagy, cell death, transcription factors, and cytokines, and were implicated in ferroptosis, abnormal lipid metabolism, inflammation, and oxidative stress pathways. Ten hub genes were screened from the constructed PPI network, including up-regulated genes such as FOS, HMOX1, SQSTM1, PTGS2, ATF3, DDIT3, and down-regulated genes MCM4, KIF15, UHRF1, and CCL2. Importantly, HMOX1 was further up-regulated in unstable plaques (p= 0.034). Finally, a regulatory network involving lncRNA/circRNA-miRNA-hub genes and drug-hub genes was established. Atherosclerotic endothelial dysfunction is associated with smoking-induced injury. Through bioinformatics analysis, we identified potential mechanisms and provided potential therapeutic targets.

Callovian Marine Reptiles of European Russia

Our knowledge of marine reptiles of the Callovian age (Middle Jurassic) is majorly based on the collections from the Oxford Clay Formation of England, which yielded a diverse marine reptile fauna of plesiosaurians, ichthyosaurians, and thalattosuchians. However, outside of Western Europe, marine reptile remains of this age are poorly known. Here, we survey marine reptiles from the Callovian stage of European Russia. The fossils collected over more than a century from 28 localities are largely represented by isolated bones and teeth, although partial skeletons are also known. In addition to the previously described rhomaleosaurid and metriorhynchids, we identify pliosaurids of the genera Liopleurodon and Simolestes; cryptoclidid plesiosaurians, including Cryptoclidus eurymerus, Muraenosaurus sp., and cf. Tricleidus, and ophthalmosaurid ichthyosaurians, including the iconic Ophthalmosaurus icenicus. These findings expand the ranges of several Callovian marine reptile taxa far to the Eastern Europe, and support the exchange of marine reptile faunas between Western and Eastern European seas in the middle to late Callovian. However, some specimens from the lower Callovian of European Russia show differences from typical representatives of the middle Callovian Oxford Clay fauna, possibly representing the earlier stages of evolution of some of these marine reptiles not yet recorded in Western Europe or elsewhere.

Exploring cultural dynamics of Black Asian Minority Ethnic (BAME) women in addiction recovery: a comparison of three women from different ethnic backgrounds

Background The existing recovery capital (RC) literature primarily focuses on white males. This study aims to fill this gap by exploring addiction recovery among three culturally diverse UK women, utilizing CHIME-D (Connectedness, Hope/Optimism, Identity, Meaning, Empowerment, and Difficulties) and RC frameworks. It seeks to compare their recovery paths, combining quantitative data with lived experiences, and barriers specific to women in recovery. Methods The article will deploy a case study design involving a mixed methods approach to explore recovery pathways and resulting RC, based on in-depth interviews and recovery capital assessments with three women from white, black and Asian ethnic backgrounds. Results While one of the three participants, reports very strong and positive RC on the REC-CAP, the other two are at a much earlier stage in their journey. In contrast to the white female participant, who lacks personal RC and has significant barriers around ongoing substance use, the Black and Asian Minority Ethnic (BAME) participants report cultural challenges and difficulties engaging with mainstream services. Conclusion Recovery is a personal and individualized journey, but one that is predicated on social support, belonging and access to cultural and community resources. For BAME participants, accessing and engaging with appropriate peer support is essential in building RC and fulfilling the requirements of CHIME.