Re-sampling and new analysis of DSDP core from key Central Atlantic sites, drilled over 30 years ago, has allowed an updated stratigraphic framework to be developed. This study refines the timing and nature of key unconformities that have previously been documented to occur elsewhere in the oceanic domain of the Central Atlantic during the drilling of many DSDP legs. Biostratigraphic dating using calcareous nannofossils and palynology has been performed on 168 samples. This higher biostratigraphic resolution improves regional correlation and has allowed identification of major hiati previously unrecognised within the oceanic domain stratigraphy.This work builds on the pioneering work of the DSDP cruises, and utilises the valuable data collected for new age dating, supplemented with new organic geochemistry analysis and sedimentological characterisation to improve documentation of the Mesozoic strata. Results are extrapolated along the continental margin of northwest Africa and the conjugate in South America, using regional two-dimensional seismic sections, providing a correlation between the oceanic domain stratigraphy and shelfal depositional systems penetrated by hydrocarbon exploration wells.At DSDP Site 367, a middle Berriasian unconformity is recognised for the first time in Core 33, where middle Berriasian white pelagic limestones (Blake-Bahama Formation) sit unconformably on Early Tithonian red argillaceous limestones (Cat Gap Formation). Faunal dating indicates a ca. 5 Myr hiatus at the Jurassic-Cretaceous boundary. Marl interbeds within the pelagic limestones increase in occurrence through the Barremian, reflecting increased terrigenous input, with associated total organic content (TOC) averaging 5%.A second major lithological break is identified at DSDP Site 367, interpreted as a base Albian unconformity, between the Blake-Bahama and overlying Hatteras Formations. Sediments above are intra late Albian variegated claystones with abundant terrestrial detritus and distal turbidites. Seismic data that intersects the well location show onlapping reflections of early-middle Albian strata landward of DSDP Site 367, indicating paleo-topography prior to Albian deposition. These sediments are contemporaneous with a major progradational phase on the shelf and a sedimentary wedge observed at the base of the carbonate escarpment. Early Albian sediments sit above the interpreted base Albian unconformity at DSDP Site 534 A on the conjugate US Atlantic margin, suggesting the super-regional nature of this event. The refined dating provides age calibration of a basin-wide unconformity, previously known from seismo-stratigraphic studies as Reflector β.In addition to the revised stratigraphic framework, evidence is presented for the occurrence of seaward dipping reflectors (SDRs) northwest of the Guinea Plateau. SDRs have not been reported along this section of the African margin, demonstrating volcanic addition during early seafloor spreading and extending the occurrence of volcanics associated with the African Blake Spur magnetic anomaly further south beyond the Cap Vert fracture zone previously mapped. At DSDP Site 368 we also note that the late Albian to late Cenomanian strata (Hatteras Formation) is composed of a 164 m thick organic-rich interval, containing up to 37% TOC, with facies and organic geochemical heterogeneity. This transgressive sequence is associated with a flooding of the shelf.This revised stratigraphic framework provides a solid foundation for future Central Atlantic studies intending to use these sites as calibration of the oceanic domain stratigraphy.