Early Postoperative Care Research Articles

One stage anterior sagittal sphincter saving anorectoplasty (ASSSARP) for the repair or rectovestibular fistula: mid and long-term outcome in two tertiary centers

PurposeThis is a retrospective study of one-stage anterior sagittal sphincter saving anorectoplasty (ASSSARP) for repairing rectovestibular fistula (RVF) including operative details and postoperative complications, functional and cosmetic outcome.Patients and methodsRecords of 41 cases of RVF, managed between April 2010 and September 2019 by one-stage ASSSARP, were reviewed. Preoperative preparation, both early and late postoperative care & complications, hospital stay, and functional & cosmetic outcomes were reported.ResultsThe mean age was 6.6 months. Vaginal tear occurred in 5/41 cases, and distal rectal tears in 4/41 cases. Thirteen patients suffered mild superficial wound inflammation; while Skin dehiscence; occurred in five patients. No colostomy or redo was needed. The mean hospital stay was 6.1 days. Mean follow-up was 43.13 months; (Range; 24–100 months). Subclinical anal stricture was detected in six patients. Constipation occurred in 14 cases. Soiling grade I occurred in five patients. Thirty-two patients reached past the age of three years; two of whom showed cough/diarrhea incontinence.ConclusionOne-stage ASSSARP is safe and gives functional and cosmetic results comparable to other techniques. It provides better access during RVF repair. The avoidance of muscle incision protects against muscle breakdown, if infection sets in, and thus against incontinence. It avoids the morbidity, cost and psychological burden of performing a three-stage repair.

Post Bariatric Surgery Nursing Care

Morbid obesity is defined as having a body mass index (BMI) above 40 or having a BMI of 35 and comorbidities along with obesity. Bariatric surgeries can be grouped into three. These are restrictive surgeries, malabsorption (impairing absorption) surgeries, and both restrictive and malabsorption surgeries. In bariatric surgery, restrictive surgeries such as vertical band gastroplasty (VGB), adjustable gastric banding (AGB) surgeries, malabsorption surgeries such as biliopancreatic diversion (BPD)/duodenal switch (DS) surgeries, and both restrictive and malabsorption surgeries such as Roux-en-Y gastric bypass (RYGB) surgeries, are commonly performed. Post-bariatric surgery care should include a multidisciplinary team consisting of a surgeon, an endocrinologist, a psychiatrist, a dietitian, and a nurse specializing in bariatric surgery. Nursing care after obesity surgery is evaluated as early postoperative care (1-3 days) and late postoperative care. Close observation, careful and complete evaluation are important in the specialist nursing care of bariatric surgery patients. In bariatric surgery, patients are provided with routine post-operative nursing care such as oxygen and hemodynamic monitoring, pain management, mobilization, wound care, deep vein thrombosis prophylaxis, early and frequent ambulation, drain care, fluid balance nutrition, training, and emotional support.

The Effect of Video-Assisted Education on Knee Function and Quality of Life after Total Knee Replacement: A Randomized Controlled Trial

Objective: This study aims to investigate the effect of video-assisted patient education (VPE) on knee functions, quality of life (QoL) and decrease complications in total knee replacement (TKR) patients. Methods: This study is designed as a prospective, parallel, two-arm, randomized clinical trial. It included 44 patients who underwent elective TKR at an orthopedics and traumatology clinic. The VPE group received VPE including early postoperative care for TKR, activities of daily living, and gradual exercise program in addition to the existing routine care at the clinic. The control group received only routine care. The results were collected with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Short Form-36 (SF-36) scores measured at baseline, 1st and 3rd months after TKR. Results: The mean scores of the VPE group on the pain, stiffness, and physical function of the WOMAC were significantly lower in 3rd month after TKR than the control group. The VPE group had significantly higher scores than the control group on SF-36 of all subcategories except pain, emotional role, and mental health in 3rd month after TKR. Conclusion: The VPE can improve knee function and QoL in TKR patients. Nurses can use the VPE method in patients to improve knee functions and QoL after TKR.

Effect of Surgery Setting for Outpatient Shoulder Procedures on Early Postoperative Complications in a Military Population

There has been a recent push to transition procedures previously performed at hospital-based outpatient surgical departments (HOPDs) to ambulatory surgery centers (ASCs). However, limited data regarding differences in early postoperative complications and care utilization (e.g., emergency department visits and unplanned admissions) may drive increased overall costs or worse outcomes. /Hypothesis: The purpose of this study was to examine differences in early 90-day adverse outcomes and postoperative emergency department visits associated with shoulder surgeries excluding arthroplasties that were performed in HOPDs and ASCs in a closed military health care system. We hypothesized that there would be no difference in outcomes between treatment settings. We retrospectively evaluated the records for 1,748 elective shoulder surgeries from 2015 to 2020. Patients were considered as one of two cohorts depending on whether they underwent surgery in an ASC or HOPD setting. We evaluated groups for differences incomplexity, surgical time, and medical risk. Outcome measures were emergency department visits, unplanned hospital admissions, and complications within the first 90 days after surgery. There was no difference in 90-day postoperative emergency department visits between procedures performed at HOPDs (n = 606) and ASCs (n = 1142). There was a slight increase in rate of unplanned hospital admission within 90 days after surgery in the HOPD cohort, most commonly for pain or overnight observation. The surgical time was significantly shorter (105 vs 119 minutes, p <0.01) at the ASC, but there was no difference in case complexity between the cohorts (p = 0.28). Our results suggest that in appropriate patients, surgery in ASCs can be safely leveraged for its costs savings, efficiency, patient satisfaction, decreases in operative time, and potentially decreased resource utilization both during surgery and in the early postoperative period.

Success Predictors of Endoscopic Sleeve Gastroplasty

ObjectiveEndoscopic sleeve gastroplasty (ESG) is a minimally invasive procedure that proved to be safe and effective in obesity treatment. However, not all subjects respond to treatment in the same way, and, with a view to personalized care, it is essential to identify predictors of success or failure.MethodsA retrospective 2-year followed-up cohort of ESG subjects was analyzed to investigate the presence of any baseline or early indicators of long-term optimal or suboptimal ESG outcomes.ResultsA total of 315 subjects (73% women) were included, with 73% of patients exhibiting an Excess weight loss percentage (%EWL) >25% at the 24 months. Neither demographic parameters (age and sex), smoking habits, and menopause in women nor the presence of comorbidities proved potential predictive value. Interestingly, the %EWL at 1 month after ESG was the strongest predictor of 24-month therapeutic success. Subsequently, we estimated an “early threshold for success” for 1 month-%EWL by employing Youden’s index method.ConclusionsESG is a safe and effective bariatric treatment that can be offered to a wide range of subjects. Early weight loss seems to impact long-term ESG results significantly and may allow proper early post-operative care optimization.Graphical

Intraoperative Features Improve Model Risk Predictions After Coronary Artery Bypass Grafting

BackgroundIntraoperative physiologic parameters could offer predictive utility in evaluating risk of adverse postoperative events yet are not included in current standard risk models. This study examined whether the inclusion of continuous intraoperative data improved machine learning model predictions for multiple outcomes after coronary artery bypass grafting, including 30-day mortality, renal failure, reoperation, prolonged ventilation, and combined morbidity and mortality (MM). MethodsThe Society of Thoracic Surgeons (STS) database features and risk scores were combined with retrospectively gathered continuous intraoperative data from patients. Risk models were developed for each outcome by training a logistic regression classifier on intraoperative data using 5-fold cross-validation. STS risk scores were included as offset terms in the models. ResultsCompared with the STS Risk Calculator, models developed using a combination of the intraoperative features and the STS preoperative risk score had improved mean area under the receiver operating characteristic curve for prolonged ventilation (0.750 [95% CI, 0.690-0.809] vs 0.800 [95% CI, 0.750-0.851]) and MM (0.695 [95% CI, 0.644-0.746] vs 0.724 [95% CI, 0.673-0.775]). Additionally, models developed using intraoperative features had improved calibration, measured with Brier score, for prolonged ventilation (0.060 [95% CI, 0.050-0.070] vs 0.055 [95% CI, 0.045-0.065]) and MM (0.092 [95% CI, 0.081-0.103] vs 0.087 [95% CI, 0.075-0.098]). ConclusionsThe inclusion of time series intraoperative data in risk models may improve early postoperative care by identifying patients who require closer monitoring postoperatively.

Selected aspects of early postoperative care after coronary artery bypass grafting in an advanced nursing practice perspective

Selected aspects of early postoperative care after coronary artery bypass grafting in an advanced nursing practice perspective

The effect of video-assisted training on upper extremity problems and functions after rotator cuff repair: a randomized controlled trial.

The shoulder is the most mobile joint in the body, and is frequently exposed to injuries. The applied surgical treatments, protection of the shoulder after surgery, care in the use of the shoulder in activities of daily living (ADLs) and gradual exercise programs are all vital to the recovery process. The present study investigates the effect of video-assisted training (VAT) on upper extremity complications and functions after rotator cuff repair (RCR). Included in this prospective, parallel two-armed, randomized controlled study were an experimental group (n: 24) that received VAT detailing early postoperative care for RCR and instructions on performing ADLs, and that had access to a 90-day gradual exercise program, and a control group (n: 24) that received routine care. The primary outcomes were upper extremity problems and functions, as assessed by the Disabilities of the Arm, Shoulder and Hand (DASH) and modified Constant-Murley scores (MCM), while secondary outcomes were complications that had developed within the past three months. The outcomes were measured at baseline, after six weeks and at three months. After 3 months, a statistically significant difference was noted in the DASH-Work (p = 0.001) and MCM ADLs scores (p = 0.003) of the two groups, and significant changes in which the scale scores of both groups when compared to the initial measurement. Only one patient in the VAT group developed complications after RCR at one month; there were no significant differences in the complications of the two groups (p = 0.235). VAT can increase function in RCR patients. Healthcare professionals, especially nurses, can use the VAT method to improve shoulder function in patients after RCR.

The Cost-Effectiveness of Early High-Acuity Postoperative Care for Medium-Risk Surgical Patients.

Initiatives in perioperative care warrant robust cost-effectiveness analysis in a cost-constrained era when high-value care is a priority. A model of anesthesia-led early high-acuity postoperative care, advanced recovery room care (ARRC), has shown benefit in terms of hospital and patient outcomes, but its cost-effectiveness has not yet been formally determined. Data from a previously published single-center prospective cohort study of ARRC in medium-risk patients were used to generate a Markov model, which described patient transition between care locations, each with different characteristics and costs. The incremental cost-effectiveness ratio (ICER), using days at home (DAH) and hospital costs, was calculated for ARRC compared to usual ward care using deterministic and probabilistic sensitivity analysis. The Markov model accurately described patient disposition after surgery. For each patient, ARRC provided 4.3 more DAH within the first 90 days after surgery and decreased overall hospital costs by $1081 per patient. Probabilistic sensitivity analysis revealed that ARRC had a 99.3% probability of increased DAH and a 77.4% probability that ARRC was dominant from the perspective of the hospital, with improved outcomes and decreased costs. Early high-acuity care for approximately 24 hours after surgery in medium-risk patients provides highly cost-effective improvements in outcomes when compared to usual ward care.

Multimodal perioperative management programme on postoperative discomfort among clients undergoing abdominal surgery at a selected hospital in Mangaluru

Introduction and Aim: Apart from pain, numerous causes contribute to discomfort during the postoperative period. Hence, early postoperative nursing care should focus on reducing this discomfort. The present study aimed to find the effect of a management programme on postoperative discomfort (MPMP) among patients undergoing abdominal surgery. Materials and Methods: This quasi-experimental study was conducted in a selected tertiary care hospital and included 183 adult patients who underwent laparotomy. The MPMP includes preoperative education, early ambulation, deep breathing exercises, and incentive spirometry. The participants were randomized into two interventional and one control group. The Intervention Group I patients performed deep breathing exercises and early ambulation after preoperative education, while Group II patients practiced incentive spirometry and early ambulation with preoperative education. The study included a control group who received routine nursing care. The primary outcome variable is postoperative discomfort (measured on days 1,3, and 5). Results: The MPMP showed a significant difference in discomfort factors like pain during day1(p=0.007) and days 3 and 5 (p&lt;0.001). Non-pain symptoms such as nausea, vomiting, movement restriction discomfort due to IV drips, and feeling cold showed higher significance for Groups I and II on days 3 and 5. Similarly, dry mouth, abdominal distension, and constipation showed a significant difference (p&lt;0.05) on days 3 and 5 between the groups at a 5% significance level. Conclusion: This study showed that postoperative discomforts could be minimized by the early practice of the MPMP program in patients undergoing surgery.

Абдоминальный крипторхизм на фоне полной диссоциации яичка и семявыносящего протока, имитирующей синдром тестикулярной регрессии.

Introduction. Complete separation of the deferent duct from the epididymis with the testicle in abdominal cryptorchidism cases is an extremely rare variation of abnormal development of genitals in boys. Available sources mention just 3 clinical cases similar to our observations. The unique anatomic details of the abnormality and extreme rarity of its exposure pave the way for a failure to reveal an intra-abdominal testis, and determine the need for particular attention during diagnostic laparoscopy. Materials and methods. Two patients with non-palpable left-sided cryptorchidism underwent a diagnostic laparoscopy, which revealed an intra-abdominal testis with epididymis on testicular vessels that was completely separated from the deferent duct. The difference between the described clinical cases was in the distance between the deep inguinal ring and the crossing of testicular vessels from the retroperitoneal location to the intraperitoneal position, which was approximately 3- 4 cm in the first patient and 4-5 mm in the second one. The second difference was in the "closed" deep inguinal ring found on the left side in the first case while the second patient had a patent processus vaginalis case. In both cases an incision was made in the left inguinal area, the inguinal canal was opened, and exploration thereof revealed blind-ended deferent ducts. The testicle in both cases was brought down through the inguinal canal and attached in the scrotum. Results. No complications occurred during the early postoperative care period, the check-up examination in 6 months following the surgery revealed no signs of testis atrophy or malposition in both patients. Conclusion. In diagnostic laparoscopy for abdominal cryptorchidism, it is important to consider the possibility of complete separation of the testicle and vas deferens. Detection of the deferent duct passing through the «closed» deep inguinal ring together with hypoplastic vessels does not rule out the chances for an ipsolateral intra-abdominal testis; therefore, a careful examination of the abdominal cavity along the embryological testicular migration path is necessary.

Unplanned Return to Cardiac Intensive Care Unit of Children After Congenital Heart Surgery: Incidence, Outcomes, and Risk Factors.

Factors leading to an unplanned return to the cardiac intensive care unit (CICU) in children after congenital heart disease and their impact on mortality have not been well characterized. We sought to determine the incidence and outcomes of unplanned return to the CICU. A secondary objective was to identify risk factors. Retrospective analysis of the registration data collected by our unit. The study subjects included postoperative patients with congenital heart disease who survived to initial transfer out of the CICU. Patients who unexpectedly returned to the CICU due to an acute change in clinical status were defined as unplanned returns. Demographic, preoperative, intraoperative, and postoperative variables were assessed. Univariate comparisons were performed between the return group and non-return group, and multivariate regression analysis was performed to identify potential risk factors for unplanned return to the CICU. Of the 531 children who met the inclusion criteria, 29 were unplanned returns to the CICU. Respiratory symptoms (41.4%) and cardiac symptoms (44.8%) were the most common reasons for returning to the CICU. Patients with unplanned returns had a higher mortality rate (13.8% vs. 0.56%, P < 0.01). In multivariate analysis, unplanned CICU admission was associated with chromosomal abnormalities (P < 0.01), longer ventilator duration (P < 0.01), and more prolonged cardiopulmonary bypass (P < 0.01) was associated with a return to independence. Unplanned return to the CICU during the same hospital stay was uncommon but associated with higher mortality. Chromosomal abnormalities, longer ventilator use duration, and prolonged CPB were significant risk factors for the entire cohort. We hope to minimize the impact of unplanned return after congenital heart disease surgery by changing the process of transferring these high-risk postoperative patients out of the CICU and early postoperative care.

Optimal, Early Postoperative Management of Cardiac Transplant and Durable Left Ventricular Assist Recipients.

Summarize developments in the early postoperative care of patients undergoing cardiac transplantation or left ventricular assist device implantation. Provide a practical approach with personal insights to highly complex patients at risk for prolonged hospitalization. Advancements in technology allow for percutaneous mechanical circulatory support of both the right and left ventricles either isolated or combined via subclavian and neck vessels. Since the adult heart allocation system has been changed to reduce waitlist mortality, the use of temporary mechanical circulatory support has increased. This has influenced preoperative optimization by enabling ambulation and majorly changed postoperative strategy. New doors have been opened for a multidisciplinary approach to facilitate rapid weaning of inotropic medications, limitation of sedation, early liberation from mechanical ventilation, and mobilization. Individualized percutaneous mechanical circulatory support offers new possibilities for the early postoperative management of highly complex patients undergoing cardiac transplantation or durable left ventricular assist device implantation.

Return to Sport Following Anterior Cruciate Ligament Reconstruction: Women's Soccer

Soccer is largely recognized as the most popular sport in the world. It involves speed, agility and endurance, requiring its athletes to sprint, explode to the ball, change direction and maintain high thresholds of work for prolonged periods. In the United States, as many as 80,000 high school female athletes experience ACL injuries each year. Females tend to be more at risk for ACL injury for a multitude of reasons including biomechanical, neuromuscular activation patterns, strength imbalances and hormonal factors. Athletes and their families are becoming increasingly aware of this risk and the subsequent risk of not returning to their pre-injury level of play; thus, necessitating both preventative and post injury rehabilitation programs aimed at maximizing function and minimizing subsequent injury. A program that focuses on neuromuscular activation patterns, proprioception and balance training, functional strength, agility, landing techniques and quality of footwork is best for mitigating risk of ACL injuries in female soccer players. This post-surgical ACL reconstruction rehabilitation program for the female soccer player has been divided into five phases, each phase a progression and building upon its preceding phase. The phases range from early post-operative care to late stage, pre-clearance to return to sport guidance and have been constructed based on evidence informed guidelines focusing on maximizing function post operatively in a safe, efficient manner while minimizing risk for re-injury.

Surgical management of metatarsal fracture using wire suture in a sheep: A case report

Background: The most frequent orthopedic condition that prevents animals from moving normally is a long-bone fracture. The diagnosis and surgical treatment of closed metatarsal fracture in sheep are the main goals of this study. Materials and Methods: A three-month-old female sheep was presented with a history of the left metatarsal bone losing its function, pain at the fracture site, aberrant motion in the affected leg, and fluid or exudate flowing from the fracture site. While radiographs indicated an oblique metatarsal fracture of the left hind limb, palpation of the left metatarsal bone revealed discomfort and fracture fragments. Following internal stabilization with cerclage wire suture, the fracture was treated. Surgery was carried out following the proper immobilization, aseptic procedure, and anesthetic protocol (atropine 0.04 mg/kg BW intramuscularly, five minutes later: xylazine 0.06 mg/kg BW intravenously). Results: The sheep was released from the hospital after the procedure bearing weight on the limb effectively and without any issues. A successful clinical outcome was obtained after surgical alteration. Conclusions: Open fractures necessitate swift, aggressive debridement, stability of the fracture, and early soft tissue restoration. The only practical method for managing fractures may be early surgical treatment and post-operative care.

Evaluation of perioperative parameters in patients undergoing radical cystectomy urinary diversion surgery for bladder cancer

Purpose: The aim of this study was to evaluate the effect of red blood cell transfusion and/or inotropic/vasopressor agent infusion during intraoperative and postoperative first 24-hour period on 30-day and one-year survival.&#x0D; Materials and Methods: In the final analysis, 133 patients who underwent radical cystectomy and urinary diversion surgery between November 2011 and January 2019 were included in this study. Perioperative anesthesia management early postoperative intensive care patient follow-ups were based on.&#x0D; Results: A statistically significant relationship was found between intraoperative red blood cell transfusion and one-year mortality rates. A statistically significant relationship was found between red blood cell transfusion in the intensive care unit and postoperative 30-day mortality rates. The relationship between vasopressor/inotrope agent infusion in intensive care unit and postoperative 30-day mortality was statistically significant.&#x0D; Conclusion: In radical cystectomy and urinary diversion, intraoperative red blood cell and/or inotrope/vasopressor drug administration, and red blood cell transfusion within first 24 postoperative hours in intensive care unit are associated with lower survival rates in both early and late periods. Future studies should focus on developing and implementing different strategies for perioperative blood management and maintenance of patient hemodynamics that may affect early and late outcomes.

Preliminary study of reliability of transcutaneous sensors in measuring intraabdominal pressure

Early recognition of elevated intraabdominal pressure (IAP) in critically ill patients is essential, since it can result in abdominal compartment syndrome, which is a life-threatening condition. The measurement of intravesical pressure is currently considered the gold standard for IAP assessment. Alternative methods have been proposed, where IAP assessment is based on measuring abdominal wall tension, which reflects the pressure in the abdominal cavity. The aim of this study was to evaluate the feasibility of using patch-like transcutaneous sensors to estimate changes in IAP, which could facilitate the monitoring of IAP in clinical practice. This study was performed with 30 patients during early postoperative care. All patients still had an indwelling urinary catheter postoperatively. Four wearable sensors were attached to the outer surface of the abdominal region to detect the changes in abdominal wall tension. Additionally, surface EMG was used to monitor the activity of the abdominal muscles. The thickness of the subcutaneous tissue was measured with ultrasound. Patients performed 4 cycles of the Valsalva manoeuvre, with a resting period in between (the minimal resting period was 30 s, with a prolongation as necessary to ensure that the fluid level in the measuring system had equilibrated). The IAP was estimated with intravesical pressure measurements during all resting periods and all Valsalva manoeuvres, while the sensors continuously measured changes in abdominal wall tension. The association between the subcutaneous thickness and tension changes on the surface and the intraabdominal pressure was statistically significant, but a large part of the variability was explained by individual patient factors. As a consequence, the predictions of IAP using transcutaneous sensors were not biased, but they were quite variable. The specificity of detecting intraabdominal pressure of 20 mmHg and above is 88%, with an NPV of 96%, while its sensitivity and PPV are currently far lower. There are inherent limitations of the chosen preliminary study design that directly caused the low sensitivity of our method as well as the poor agreement with the gold standard method; in spite of that, we have shown that these sensors have the potential to be used to monitor intraabdominal pressure. We are planning a study that would more closely resemble the intended clinical use and expect it to show more consistent results with a far smaller error.

Care related to information sharing with families by nurses providing early postoperative nursing care

Care related to information sharing with families by nurses providing early postoperative nursing care

Outcome of surgical condition of neonates who underwent surgery: A prospective study from a tertiary care center.

The neonatal period is a highly vulnerable time for an infant, who is completing many of the physiologic adjustments required for extra- uterine survival. If the neonate has a coexisting pathology which needs surgery, this challenge is magnified. Neonatal surgical conditions are unique in their type because some require early diagnosis, prompt surgery and postoperative care to improve the survival and outcome. The aim of this study was to know the clinical profile of congenital surgical conditions and to estimate the burden and outcome in special new born care unit. The study population include 138 surgical neonate admitted in special new born care unit, department of paediatrics, Kamla Raja Hospital, Gajra Raja Medical College, Gwalior (M.P.) from April 2017 to April 2018 including six month follow up period. Total admission in special new born care unit were 5378 out of which 138 (2.5%) neonates of surgical condition were admitted in the study period. Incidence of neonatal surgical condition was found to be 8.48%. Surgery was performed in 57 (41.30%) neonates. The Commonest neonatal surgical condition was constituted by gastrointestinal system (39.13%). Among gastrointestinal system anomalies, tracheoesophageal fistula were 28.6% of total gastrointestinal system cases. The most common surgical condition encountered was meningomyelocele, 23.36% of total cases. The survival of neonatal surgical condition in hospital was 52.89% and after six month follow up was 26.08%. The overall mortality with neonatal surgical condition in this study was 73.91%. Maternal age, antenatal care, history of congenital malformation, socioeconomic status, mode of delivery, prematurity, type of admission, single or multiple surgical condition, inotropic and ventilation support, post operative complication were significantly associated with final outcome of neonatal surgical condition. High mortality was found in neonates suffering from surgical conditions. Commonest anomaly includes conditions of gastrointestinal tract. Maternal age more than 35 year, poor antenatal care, prematurity, vaginal delivery, extra mural neonate, multiple surgical condition, inotropic and ventilation support and post operative complications were associated with increased mortality.

Can early postoperative parenteral nutrition have some impact on postoperative inflammatory response intensity?

Enhanced recovery after surgery (ERAS) is currently the modern perioperative method of care for improvement of post-surgery patient condition and for minimising various postoperative complications. A question of some negative impact of early postoperative parenteral nutrition on postoperative inflammatory response intensity has not clear-cut answer yet. This pilot project was focused on the possible influence of early parenteral nutrition on the intensity of inflammatory postoperative response to operating trauma in surgical patients. Elected as a model of these conditions were patients with colorectal cancer undergoing major surgery. 45 patients (of whom 39 were analysed finally) operated for cancer of the large bowel were enrolled into the clinical, prospective, randomized, blinded, and monocentric trial - reference number 201811 S09P of the Ethics committee, University Hospital Hradec Kralove, Czech Republic. Patients were divided into two subgroups according to the type of nutrition: subgroup A - supplemented only with 10% glucose for supported mineral carrier; and subgroup B - supplemented with total parenteral nutrition. Samples of blood and urine were examined immediately after surgery, and on the first, second, and fourth days postoperatively. The inflammatory reaction was monitored by the serum or/and urine concentration of neopterin, tryptophan, and kynurenine, and their urinary ratios with creatinine. The results were analysed by multivariate analysis, and p-values ≤ 0.05 were considered statistically significant. The final total of 39 patients comprised 20 from subgroup A and 19 from subgroup B. The intensity of the inflammatory response detected by the selected inflammatory markers (serum and urine concentrations of neopterin, kynurenine, tryptophan, their serum ratios, and their urinary ratios to creatinine) did not demonstrate statistically significant differences after early administration of the two alternative types of parenteral nutrition. The results of the study demonstrated the same or a very similar impact on the intensity of postoperative inflammatory response, regardless of whether the patient received intravenous administration of a small simple sugar infusion or total parenteral nutrition during early postoperative care.