Early Directing Attention Negativity Research Articles

Spatial Attention in Serial Order Working Memory: An EEG Study.

Theoretical models explaining serial order processing link order information to specified position markers. However, the precise characteristics of position marking have remained largely elusive. Recent studies have shown that space is involved in marking serial position of items in verbal working memory (WM). Furthermore, it has been suggested, but not proven, that accessing these items involves horizontal shifts of spatial attention. We used continuous electroencephalography recordings to show that memory search in serial order verbal WM involves spatial attention processes that share the same electrophysiological signatures as those operating on the visuospatial WM and external space. Accessing an item from a sequence in verbal WM induced posterior "early directing attention negativity" and "anterior directing attention negativity" contralateral to the position of the item in mental space (i.e., begin items on the left; end items on the right). In the frequency domain, we observed posterior alpha suppression contralateral to the position of the item. Our results provide clear evidence for the involvement of spatial attention in retrieving serial information from verbal WM. Implications for WM models are discussed.

Pre-motor deficits in left spatial neglect: An EEG study on Contingent Negative Variation (CNV) and response-related beta oscillatory activity

Right Brain Damaged patients with left spatial neglect (N+), are characterised by poor allocation of attention in the contralesional left side of space. In a recent study (Lasaponara et al., 2018) we showed during orienting of spatial attention with endogenous central cues, both the EEG markers reflecting the early phases of orienting (Early Directing Attention Negativity) and those reflecting the late setting-up of sensory facilitation in the visual cortex (Late Directing Attention Positivity) are disturbed in N+ when these patients attend the left side of space. In the healthy brain, endogenous cues also elicit EEG activity related to the preparation of manual responses to upcoming spatial targets. Here, we wished to expand on our previous findings and investigate the EEG correlates of cue-related response preparation in N+ patients. To this aim we investigated the Contingent Negative Variation (CNV) response and the pre-motor Beta-oscillatory activity evoked by spatially informative central cues during the performance of a Posner task. Due to concomitant contralesional motor impairments, N+ an N- patients performed the task only with the ipsilesional right-hand. Compared to healthy controls and patients without neglect, N+ displayed a pathological suppression of CNV component that was independent of cue direction. In addition, the amplitude of the CNV in response to right-pointing cues was positively correlated with neglect severity in line bisection. N+ also displayed a pathological enhancement of pre-motor Beta oscillations over the left hemisphere during the time period that preceded manual responses to targets in the left side of space, particularly to invalidly cued ones. Synchronization in the Beta-band (ERS) was also correlated with lower detection rate and slower RTs to Invalid targets in the left side of space. These results provide new insights on the premotor components of the spatial orienting deficits suffered by patients with left spatial neglect and can help improving its diagnosis and rehabilitation.

Large lateralized EDAN-like brain potentials in a gaze-shift detection task.

Attentional cueing tasks using gaze direction as spatial cues have sometimes yielded an early directing attention negativity (EDAN) component in the ERP, presumably reflecting the initial orienting toward the cued location. However, other studies have failed to identify an EDAN component for gaze cues, yielding an inconsistent picture. In the present study, we re-examined the EDAN to gaze cueing, using a continuous task where the specific direction of the gaze changes was task irrelevant. Face stimuli changed gaze direction several times during each trial between direct, left-, and right-averted positions. Participants counted the number of gaze shifts during the trial. Results showed an unusually large EDAN-like ERP asymmetry at posterior scalp sites that was of similar amplitude for large and small gaze shifts into the periphery. Shifts from an averted position toward a direct gaze elicited a qualitatively similar but smaller effect than shifts into the periphery. Together, these findings shed new light on gaze-elicited spatial attention as they indicate a reflexive attention orienting, following the direction of gaze motion, even when the gaze direction itself is irrelevant for the task.

The role of the motion cue in the dynamic gaze-cueing effect: A study of the lateralized ERPs

When face was inverted, dynamic gaze cues could still effectively direct attention despite the disruption of configural face processing, but the static gaze cues could not. The present study investigated the role of the motion cue in the dynamic Gaze-Cueing Effect (GCE). With schematic and real faces, we employed the gaze-cueing paradigm to examine the differences among three kinds of cues (static gaze cue, dynamic gaze cue and motion cue) based on behavioral results and event-related potentials. Behavioral results revealed significant GCE in all conditions. In the schematic face group, the motion cue (two symmetrical dots shifting slightly to the side) induced a significantly smaller GCE than the dynamic gaze cues (two symmetrical dots moving within a rounded circle), while in the real face group, the motion cue (that is, the inverted-face gaze cue) remained a strong GCE compared with other conditions. With regard to the ERP results, we found the early directing attention negativity (EDAN), which was sensitive to voluntary cues (e.g. arrow cue) rather than gaze cue, in the schematic motion cue condition, but not in the inverted-face gaze cue condition. We supposed that the motion cue (real face) could activate the configural face processing even when the face is inverted. This finding supported that EDAN reflected a cue-triggered attention shift.

EEG Correlates of Preparatory Orienting, Contextual Updating, and Inhibition of Sensory Processing in Left Spatial Neglect.

Studies with event-related potentials have highlighted deficits in the early phases of orienting to left visual targets in right-brain-damaged patients with left spatial neglect (N+). However, brain responses associated with preparatory orienting of attention, with target novelty and with the detection of a match/mismatch between expected and actual targets (contextual updating), have not been explored in N+. Here in a study in healthy humans and brain-damaged patients of both sexes we demonstrate that frontal activity that reflects supramodal mechanisms of attentional orienting (Anterior Directing Attention Negativity, ADAN) is entirely spared in N+. In contrast, posterior responses that mark the early phases of cued orienting (Early Directing Attention Negativity, EDAN) and the setting up of sensory facilitation over the visual cortex (Late Directing Attention Positivity, LDAP) are suppressed in N+. This uncoupling is associated with damage of parietal-frontal white matter. N+ also exhibit exaggerated novelty reaction to targets in the right side of space and reduced novelty reaction for those in the left side (P3a) together with impaired contextual updating (P3b) in the left space. Finally, we highlight a drop in the amplitude and latency of the P1 that over the left hemisphere signals the early blocking of sensory processing in the right space when targets occur in the left one: this identifies a new electrophysiological marker of the rightward attentional bias in N+. The heterogeneous effects and spatial biases produced by localized brain damage on the different phases of attentional processing indicate relevant functional independence among their underlying neural mechanisms and improve the understanding of the spatial neglect syndrome.SIGNIFICANCE STATEMENT Our investigation answers important questions: are the different components of preparatory orienting (EDAN, ADAN, LDAP) functionally independent in the healthy brain? Is preparatory orienting of attention spared in left spatial neglect? Does the sparing of preparatory orienting have an impact on deficits in reflexive orienting and in the assignment of behavioral relevance to the left space? We show that supramodal preparatory orienting in frontal areas is entirely spared in neglect patients though this does not counterbalance deficits in preparatory parietal-occipital activity, reflexive orienting, and contextual updating. This points at relevant functional dissociations among different components of attention and suggests that improving voluntary attention in N+ might be behaviorally ineffective unless associated with stimulations boosting the response of posterior parietal-occipital areas.

How microsaccades relate to lateralized ERP components of spatial attention: A co-registration study

Covert shifts of attention that follow the presentation of a cue are associated with lateralized components in the event-related potential (ERP): the “early directing attention negativity” (EDAN) and the “anterior directing attention negativity” (ADAN). Traditionally, these shifts are thought to take place while gaze is fixated and, thus, in the absence of saccades. However, microsaccades of small amplitude (<1°) occur frequently and involuntarily also during fixation and are closely correlated with spatial attention. To investigate potential links between microsaccades and lateralized ERP components, we simultaneously recorded eye movements and ERPs in a spatial cueing task. As a first major result, we show that both the posterior EDAN and the orientation of microsaccades align more strongly with the location of the task-relevant part of the cue stimulus than with the direction of the attention shift indicated by that cue. A coupling between microsaccades and EDAN was also present on the single-trial level: The EDAN was largest when microsaccades were oriented toward the relevant cue, but absent when microsaccades were oriented away from it, suggesting that EDAN and microsaccades are generated by the same neural network, which selects relevant stimuli and orients behavior toward them. As a second major result, we show that small corneoretinal artifacts from microsaccades, which fall below conventional EOG rejection thresholds, contaminate the measurement of the ADAN. After correcting the EEG for microsaccade-related artifacts with an optimized variant of independent component analysis, ADAN was abolished at frontal sites, but a genuine ADAN was still present at central sites. Thus, the combined measurement of microsaccades and lateralized ERPs sheds new light onto cue-elicited shifts of covert attention.

Normal aging selectively diminishes alpha lateralization in visual spatial attention

EEG studies of cue-induced visual alpha power (8–13Hz) lateralization have been conducted on young adults without examining differences that may develop as a consequence of normal aging. Here, we examined age-related differences in spatial attention by comparing healthy older and younger adults. Our key finding is that cue-induced alpha power lateralization was observed in younger, but not older adults, even though both groups exhibited classic event-related potential signatures of spatial orienting. Specifically, both younger and older adults showed significant early directing-attention negativity (EDAN), anterior directing-attention negativity (ADAN), late directing-attention positivity (LDAP) and contingent negative variation (CNV). Furthermore, target-evoked sensory components were enhanced for attended relative to unattended targets in both younger and older groups. This pattern of results suggests that although older adults can successfully allocate spatial attention, they do so without the lateralization of alpha power that is commonly observed in younger adults. Taken together, our findings demonstrate that younger and older adults might engage different neural mechanisms for attentional orienting, and that alpha power lateralization during visual spatial attention is a phenomenon that diminishes during normal aging.

Eye gaze triggers reflexive attention shifts: Evidence from lateralised ERPs

Social cues, such as another individual׳s eye gaze, provide valuable information regarding the actions and intentions of others. Previous studies have suggested that seeing another׳s gaze automatically orients one׳s attention in the gaze direction. In this event-related potential (ERP) study, a spatial cuing paradigm was combined with a visual search task in which targets were defined by feature conjunctions in order to eliminate effects of target/distractor salience. Participants viewed centrally presented faces with neutral expressions in which eyes looked to the left or right. The participants׳ task was to identify a target object (with or without gap) defined by a combination of shape and orientation, which appeared in either the same (cued) or the opposite (uncued) location as the direction of the eye gaze. There was behavioural evidence of a gaze congruency effect, as reaction times (RTs) were faster when the eyes looked towards the target rather than away from the location of the target. The ERP data indicated the presence of significant gaze-congruent early directing attention negativity (EDAN) and anterior directing attention negativity (ADAN), reflecting attention shifts to the cued location in advance of the target presentation. ERP data did not show evidence of later orienting of attention triggered by gaze cues in the late attention-directing attention positivity (LDAP) at posterior sites. The results disclosed the neural response during reflexive attention shifting triggered by gazes and ascertained the relationship among EDAN, ADAN, LDAP and gaze-elicited attention shifts. After the presentation of the target array without salient stimuli, the presence of the N2-posterior-contralateral (N2pc) in the cued trials and the absence in the uncued trials further supported that attention had been directed to the possible target location prior to the target onset. The ERPs in response to the target array also extend our understanding of the neural response that orients spatial attention by providing valuable information about the temporal dynamics without the influence of salience.

Autistic traits influence gaze-oriented attention to happy but not fearful faces

The relationship between autistic traits and gaze-oriented attention to fearful and happy faces was investigated at the behavioral and neuronal levels. Upright and inverted dynamic face stimuli were used in a gaze-cueing paradigm while event related potentials (ERPs) were recorded. Participants responded faster to gazed-at than to non-gazed-at targets, and this gaze orienting effect (GOE) diminished with inversion, suggesting it relies on facial configuration. It was also larger for fearful than happy faces but only in participants with high autism-spectrum quotient (AQ) scores. While the GOE to fearful faces was of similar magnitude regardless of AQ scores, a diminished GOE to happy faces was found in participants with high AQ scores.At the ERP level, a congruency effect on target-elicited P1 component reflected enhanced visual processing of gazed-at targets. In addition, cue-triggered early directing attention negativity and anterior directing attention negativity reflected, respectively, attention orienting and attention holding at gazed-at locations. These neural markers of spatial attention orienting were not modulated by emotion and were not found in participants with high AQ scores. Together, these findings suggest that autistic traits influence attention orienting to gaze and its modulation by social emotions such as happiness.

Age Group and Individual Differences in Attentional Orienting Dissociate Neural Mechanisms of Encoding and Maintenance in Visual STM

Selective attention biases the encoding and maintenance of representations in visual STM (VSTM). However, precise attentional mechanisms gating encoding and maintenance in VSTM and across development remain less well understood. We recorded EEG while adults and 10-year-olds used cues to guide attention before encoding or while maintaining items in VSTM. Known neural markers of spatial orienting to incoming percepts, that is, Early Directing Attention Negativity, Anterior Directing Attention Negativity, and Late Directing Attention Positivity, were examined in the context of orienting within VSTM. Adults elicited a set of neural markers that were broadly similar in preparation for encoding and during maintenance. In contrast, in children these processes dissociated. Furthermore, in children, individual differences in the amplitude of neural markers of prospective orienting related to individual differences in VSTM capacity, suggesting that children with high capacity are more efficient at selecting information for encoding into VSTM. Finally, retrospective, but not prospective, orienting in both age groups elicited the well-known marker of visual search (N2pc), indicating the recruitment of additional neural circuits when orienting during maintenance. Developmental and individual differences differentiate seemingly similar processes of orienting to perceptually available representations and to representations held in VSTM.

Updating of Attentional and Premotor Allocation Resources as function of previous trial outcome

The neural bases of the inter-trial validity/invalidity sequential effects in a visuo-auditory modified version of the Central Cue Posner's Paradigm (CCPP) are analyzed by means of Early Directing Attention Negativity (EDAN), Contingent Negative Variation (CNV) and Lateralized Readiness Potential (LRP). ERPs results indicated an increase in CNV and LRP in trials preceded by valid trials compared to trials preceded by invalid trials. The CNV and LRP pattern would be highly related to the behavioral pattern of lower RTs and higher number of anticipations in trials preceded by valid with respect to trials preceded by invalid trials. This effect was not preceded by a modulation of the EDAN as a result of the previous trial condition. The results suggest that there is a trial-by-trial dynamic modulation of the attentional system as a function of the validity assigned to the cue, in which conditional probabilities between cue and target are continuously updated.

The effect of attenuating noradrenergic neurotransmission by clonidine on brain activity measures of visuospatial attention

In the current study, we investigated the role of noradrenaline in directing (bias) and disengagement of visuospatial attention. We assessed the effect of clonidine on event-related brain potential (ERP) reflections of bias and disengagement in a double-blind placebo-controlled crossover design. An initial dose of 200-μg clonidine was replaced by 100 μg because of marked side effects. Twenty-one healthy male participants performed the visual-spatial cueing task while an electroencephalogram (EEG) was recorded. The behavioral output is the validity effect (benefit of cueing in terms of reaction time to targets). ERP indices for bias were the cue-related early directing attention negativity and late directing attention positivity, and the target-elicited P1 and N1 modulations by validity ('validity-effect'). The ERP index for disengagement was the target-elicited 'late positive deflection' modulation by validity. Behavioral analyses were performed on 16 participants, electrophysiological analyses on a subset (n=9). Clonidine attenuated the N1 effect, albeit in a subsample. Neither cue-elicited ERPs nor the behavioral validity effect were affected. Clonidine-induced blood pressure reduction was correlated with the reduction of the late positive deflection effect under clonidine. Clonidine attenuated the result of bias in a subsample and may have a modulating effect on disengagement.

Fearful, surprised, happy, and angry facial expressions modulate gaze-oriented attention: Behavioral and ERP evidence

The impact of emotions on gaze-oriented attention was investigated in non-anxious participants. A neutral face cue with straight gaze was presented, which then averted its gaze to the side while remaining neutral or expressing an emotion (fear/surprise in Exp.1 and anger/happiness in Exp.2). Localization of a subsequent target was faster at the gazed-at location (congruent condition) than at the non-gazed-at location (incongruent condition). This Gaze-Orienting Effect (GOE) was enhanced for fear, surprise, and anger, compared to neutral expressions which did not differ from happy expressions. In addition, Event Related Potentials (ERPs) to the target showed a congruency effect on P1 for fear and surprise and a left lateralized congruency effect on P1 for happy faces, suggesting that target visual processing was also influenced by attention to gaze and emotions. Finally, at cue presentation, early postero-lateral (Early Directing Attention Negativity (EDAN)) and later antero-lateral (Anterior Directing Attention Negativity (ADAN)) attention-related ERP components were observed, reflecting, respectively, the shift of attention and its holding at gazed-at locations. These two components were not modulated by emotions. Together, these findings show that the processing of social signals such as gaze and facial expression interact rather late and in a complex manner to modulate spatial attention.

The feet have it: Local biological motion cues trigger reflexive attentional orienting in the brain

Most vertebrates, humans included, have a primitive visual system extremely sensitive to the motion of biological entities. Most previous studies have examined the global aspects of biological motion perception, but local motion processing has received much less attention. Here we provide direct psychophysical and electrophysiological evidence that human observers are intrinsically tuned to the characteristics of local biological motion cues independent of global configuration. Using a modified central cueing paradigm, we show that observers involuntarily orient their attention towards the walking direction of feet motion sequences, which triggers an early directing attention negativity (EDAN) in the occipito-parietal region 100–160ms after the stimulus onset. Notably, such effects are sensitive to the orientation of the local cues and are independent of whether the observers are aware of the biological nature of the motion. Our findings unambiguously demonstrate the automatic processing of local biological motion without explicit recognition. More importantly, with the discovery that local biological motion signals modulate attention, we highlight the functional importance of such processing in the brain.

Testing the dorsal stream attention hypothesis: Electrophysiological correlates and the effects of ventral stream damage

The roles of dorsal and ventral processing streams in visual orienting and conscious perception were examined in two experiments. The first employed high density EEG with source localization. The second comprised a neuropsychological case study. Visual orienting was assessed with an attention procedure, where peripheral letters cued participants towards a target location. In the perception procedure participants responded to the same letters by performing an explicit conscious discrimination. In Experiment 1, the peripheral letters elicited rapid dorsal stream activation in the attention procedure, and this activation preceded top-down enhancement of target processing in occipital cortex. In the perception procedure early ventral stream activation was seen. In addition, peripheral letters elicited an “early directing attention negativity” (EDAN) over parietal recording sites in the attention procedure, but not in the perception procedure. In Experiment 2, a patient with a bilateral ventral stream lesion but preserved dorsal stream function showed clear disruption to performance in the perception procedure, whilst exhibiting a normal visual orienting effect in the attention procedure. Taken together these findings (1) highlight the distinct roles of the dorsal and ventral streams in attention and perception, and (2) suggest how these streams might interact, via reentrant effects of attention on perceptual processing.

ERP evidence for selective drop in attentional costs in uncertain environments: Challenging a purely premotor account of covert orienting of attention

Several studies have proved that the reliability of endogenous spatial cues linearly modulates the reaction time advantage in the processing of targets at validly cued vs. invalidly cued locations, i.e. the “validity effect”. This would imply that with non-predictive cues, no “validity effect” should be observed. However, contrary to this prediction, one could hypothesize that attentional benefits by valid cuing (i.e. the RT advantage for validly vs. neutrally cued targets) can still be maintained with non-predictive cues, if the brain were endowed with mechanisms allowing the selective reduction in costs of reorienting from invalidly cued locations (i.e. the reduction of the RT disadvantage for invalidly vs. neutrally cued targets). This separated modulation of attentional benefits and costs would be adaptive in uncertain contexts where cues predict at chance level the location of targets. Through the joint recording of manual reaction times and event-related cerebral potentials (ERPs), we have found that this is the case and that relying on non-predictive endogenous cues results in abatement of attentional costs and the difference in the amplitude of the P1 brain responses evoked by invalidly vs. neutrally cued targets. In contrast, the use of non-predictive cues leaves unaffected attentional benefits and the difference in the amplitude of the N1 responses evoked by validly vs. neutrally cued targets. At the individual level, the drop in costs with non-predictive cues was matched with equivalent lateral biases in RTs to neutrally and invalidly cued targets presented in the left and right visual field. During the cue period, the drop in costs with non-predictive cues was preceded by reduction of the Early Directing Attention Negativity (EDAN) on posterior occipital sites and by enhancement of the frontal Anterior Directing Attention Negativity (ADAN) correlated to preparatory voluntary orienting. These findings demonstrate, for the first time, that the segregation of mechanisms regulating attentional benefits and costs helps efficiency of orienting in “uncertain” visual spatial contexts characterized by poor probabilistic association between cues and targets.

Neural activity associated with attention orienting triggered by gaze cues: A study of lateralized ERPs

This study investigated the electrophysiological (event-related potential, ERP) and behavioral (reaction time, RT) correlates of gaze-cued shifts of visuospatial attention. Participants viewed centrally presented faces with neutral expressions in which eyes looked straight ahead and then shifted to the left or right. Upon movement of the eyes, the facial expression either stayed the same (neutral) or changed to a fearful or happy expression. Participants' task was to identify a probe letter (T or L), which appeared in either the same or the opposite location to the direction of the eye gaze. There was behavioral evidence of a gaze congruency effect, as RTs were faster when the eyes looked toward rather than away from the location of the target. The ERP data indicated the presence of a significant gaze-congruent anterior directing attention negativity (ADAN) at anterior locations (300–500 ms after the onset of the gaze cue). ERP data did not show evidence of initial orienting of attention triggered by gaze cues in the early directing attention negativity (EDAN) at posterior locations (200–300 ms post-cue onset). The gaze cueing effects in the RT and ERP data were not significantly influenced by the emotional expression of the faces. The presence of the ADAN may reflect neural mechanisms that underlie the holding of attention on gazed-at locations.

An early parietal ERP component of the frontoparietal system: EDAN ≠ N2pc

Directing spatial attention or manual response selection by means of arrow cues elicits a characteristic sequence of lateralized ERP components. Van Velzen and Eimer (2003) proposed that one of these components, the EDAN (early directing-attention negativity) is not related to the control of spatial attention but is instead an N2pc in disguise, related to the visual processing of arrow cues. While this proposal seems widely accepted, it has never been evaluated whether the hitherto not well-determined scalp distribution of the EDAN matches the well-established scalp distribution of the N2pc. This paper reviews evidence from earlier published work supporting a parietal distribution of the EDAN. This strongly argues against the proposed identification with the N2pc. The EDAN may instead reflect early parietal activity within the frontoparietal network, preceding the frontal activation represented in the anterior directing-attention negativity (ADAN).

Attentional orienting induced by arrows and eye-gaze compared with an endogenous cue

Exogenous orienting has been widely studied by using peripheral cues whereas endogenous orienting has been studied with directional central cues. However, recent evidence has shown that centrally presented eye-gaze and arrows may produce an automatic rather than voluntary orienting of attention. Therefore, the aim of the present study was to investigate the behavioural and electrophysiological (event-related potentials—ERP) correlates of the attentional shift induced by arrows and eye-gaze. In order to have a control condition, we compared arrows and eye-gaze with a purely endogenous cue, i.e., a texture arbitrarily coding one direction. We analyzed the ERP components (P1, N1, P2a, P2p, P3) elicited by the cue stimuli and the early lateralised attentional effect (early directing attention negativity—EDAN). In addition, in order to investigate the topography of the neural mechanisms underlying the cortical activity in each cueing condition, we applied a temporal segmentation procedure. The results showed that the three cueing conditions induced a different strength of activation within the same cortical network. Occipito-parietal regions were involved in the early processing of visual information, followed by an involvement of frontal areas, likely implicated in learning associations. These data confirm the assumption that, in contrast to purely endogenous cues, arrows and eye-gaze induce a very fast attentional shift. However, the similarity of the ERP components and of the topographical cortical maps among conditions suggest that this early orienting of attention is more likely related to an overlearned association mechanism rather than to a real exogenous attentional process.

An ERP study of preparatory and inhibitory mechanisms in a cued saccade task

The present study uses event-related potentials (ERPs) to investigate the neurophysiological correlates of the mechanisms involved in selection of locations for saccades. Participants performed a task in which both target and distractor locations were cued on a trial-by-trial basis. Participants were instructed to make an eye movement to the cued target location and to ignore elements at the distractor location. This experimental set-up allowed the investigation of the mechanisms involved in the top-down preparation and inhibition of locations for an eye movement. When comparing responses to leftward and rightward pointing cues, we observed an early directing attention negativity (EDAN) and an anterior directing attention negativity (ADAN) effect in the cue–target interval. These effects were similar to those observed in studies investigating attentional allocation, suggesting a close link between shifts of spatial attention and the preparation of eye movements. These components were followed by a late widespread contralateral negativity (LDAN) that was assumed to reflect both the oculomotor programming of the upcoming eye movement as well as attentional orienting. Furthermore, a new component was observed related to top-down inhibition of the distractor location. In response to the distractor cue, an early positivity above the right hemisphere (RLIP) was revealed. Finally, no modulations of early target-evoked ERP components were observed, suggesting that these components are unaffected when no further processing is required at the cued location.