Early Detection Of Suspicious Lesions Research Articles

Computed tomography findings, associated factors, and management of pulmonary nodules in 54,326 healthy individuals.

To investigate the pulmonary nodules detected by low-dose computed tomography (LDCT), identified factors affecting the size and number of pulmonary nodules (single or multiple), and the pulmonary nodules diagnosed and management as lung cancer in healthy individuals. A retrospective analysis was conducted on 54,326 healthy individuals who received chest LDCT screening. According to the results of screening, the detection rates of pulmonary nodules, grouped according to the size and number of pulmonary nodules (single or multiple), and the patients' gender, age, history of smoking, hypertension, and diabetes were statistically analyzed to determine the correlation between each factor and the characteristics of the nodules. The pulmonary nodules in healthy individuals diagnosed with lung cancer were managed with differently protocols. The detection rate of pulmonary nodules was 38.8% (21,055/54,326). The baseline demographic characteristics of patients with pulmonary nodules were: 58% male and 42% female patients, 25.7% smoking and 74.3% nonsmoking individuals, 40-60 years old accounted for 49%, 54.8% multiple nodules, and 45.2% single nodules, and ≤5-mm size accounted for 80.4%, 6-10 mm for 18.2%, and 11-30 mm for 1.4%. Multiple pulmonary nodules were more common in hypertensive patients. Diabetes is not an independent risk factor for several pulmonary nodules. Of all patients with lung nodules, 26 were diagnosed with lung cancer, accounting for 0.1% of all patients with pulmonary nodules, 0.6% with nodules ≥5 mm, and 2.2% with nodules ≥8 mm, respectively. Twenty-six patients with lung cancer were treated with surgical resection (57.7%), microwave ablation (MWA, 38.5%), and follow-up (3.8%). LDCT was suitable for large-scale pulmonary nodules screening in healthy individuals, which was helpful for the early detection of suspicious lesions in the lung. In addition to surgical resection, MWA is an option for early lung cancer treatment.

Pannus Is the New Prepuce? Penile Cancer in a Buried Phallus.

Two males presented to our urology department with complaints of bleeding and malodor from buried phallus within a suprapubic fat pad. Although both men had neonatal circumcisions, advanced penile carcinoma was found in both men. Formal penectomies showed high grade, poorly differentiated squamous cell carcinoma invading the corporal bodies and urethra. Buried penis represents a difficulty in early detection of suspicious lesions but may also provide an environment susceptible to poor hygiene and subsequent chronic inflammation. Patients with buried penis may be at a higher risk for development of invasive penile cancer and may benefit from regular and thorough genital exams.

Skin Cancer Education for Massage Therapists: A Novel Approach to the Early Detection of Suspicious Lesions

Studies indicate that with training, nonmedical health professionals may be able to successfully recognize lesions suspicious for skin cancer and thereby assist with early detection of suspicious lesions. We present the results of a study aimed at assessing the efficacy of a 4-h continuing education program designed to educate massage therapists about skin cancer detection and prevention. Prior to and after the administration of the course, surveys were administered to attendees to gauge their ability to identify skin cancer and their comfort level with counseling clients with suspicious lesions. Our study suggests that while many massage therapists are educated on skin cancer and have experience referring patients for suspicious lesions, a 4-h educational session may not be sufficient to improve sensitivity of detection.

Improving the diagnostic accuracy of dysplastic and melanoma lesions using the decision template combination method

Melanoma is the most dangerous type of skin cancer, and early detection of suspicious lesions can decrease the mortality rate of this cancer. In this article, we present a multi-classifier system for improving the diagnostic accuracy of melanoma and dysplastic lesions based on the decision template combination rule. First, the lesion is differentiated from the surrounding healthy skin in an image. Next, shape, colour and texture features are extracted from the lesion image. Different subsets of these features are fed to three different classifiers: k-nearest neighbour (k-NN), support vector machine (SVM) and linear discriminant analysis (LDA). The decision template method is used to combine the outputs of these classifiers. The proposed method has been evaluated on a set of 436 dermatoscopic images of benign, dysplastic and melanoma lesions. The final classifier ensemble delivers a total classification accuracy of 80.46%, with 67.73% of dysplastic lesions correctly classified and 83.53% of melanoma lesions correctly classified. The results show that the proposed method significantly increases the diagnostic accuracy of dysplastic and melanoma lesions compared with a single classifier. The total classification rate is also improved.

Clinical applications of magnifying laryngoscopy on nasopharyngeal examination.

To evaluate the usability of magnifying laryngoscopy for the diagnosis of nasopharyngeal diseases. An analysis was made on the nasopharyngeal figure and letter data among 6774 cases undergone magnifying laryngoscopy. Among these cases, biopsy would be given to those with suspected lesion in the nasopharynx carried out under magnifying laryngoscopy or endoscope. Compliance of patients to magnifying laryngoscopy at the rate of 98.9% (6700/6774) was superior to indirect nasopharyngoscopy 30.9% (2095/6774). The difference was statistically significant (chi(2) = 6872.75, P < 0.005). Magnifying laryngoscopy could clearly show a variety of diseases in nasopharynx, early detection of suspicious lesions. Among 615 cases, both fiber nasopharyngoscopy (192 cases) and nasal endoscopy (423 cases) with nasopharyngeal uplift were used, magnifying laryngoscopy found 418 cases bilateral symmetry, the surface smooth, no abnormal. The pathological examination confirmed normal tissue. Other 197 cases in the larger laryngoscopy also showed the uplift in nasopharynx by pathologically examination confirmed a variety of benign and maligant lesions. Magnifying laryngoscopy with strong brightness, high resolution, can early detect the nasopharyngeal lesions, increase the diagnostic accuracy rate and biopsy-positive rate. Therefore, it is valuable for the diagnosis of nasopharyngeal diseases.