Early Detection Of Metastatic Cancer Research Articles

Metastasis of Mixed Adenoneuroendocrine Carcinoma of the Uterine Cervix to Thyroid Gland.

The thyroid metastasis from cervical cancer is extremely rare compared to other organs. It is sometimes difficult to distinguish primary tumors from metastases, as most metastatic thyroid nodules are asymptomatic. In this case, a 54-year-old woman had undergone radical hysterectomy due to cervical tumor of stage IB1 mixed adenoneuroendocrine carcinoma (MANEC) 5 years ago. After 3 years, ultrasound examination revealed a suspicious malignant nodule in the left lobe of thyroid gland at regular postoperative follow-up. This patient had no obvious clinical symptoms. The ultrasonography (US)-guided core needle biopsy (CNB) of the thyroid nodule was performed on the patient. The immunohistochemistry analyses revealed that it was poorly differentiated small-cell neuroendocrine carcinoma (SCNEC). Subsequently, the patient underwent left hemithyroidectomy plus isthmusectomy. The postoperative pathology and immunohistochemistry, combining with clinical history, confirmed that the thyroid nodule was a metastasis from cervical MANEC. Conventional chemotherapy and regular follow-up were carried out after the operation. The patient was readmitted 1 year later for pancreatic metastatic lesions and died 1 month after surgery. Early detection of metastatic cancer is potentially helpful, and when necessary, ultrasound-guided puncture biopsy can be utilized to further diagnose metastatic thyroid cancer.

Calcium Isotopic Composition and Its Association With Multiple Myeloma Disease Activity

Calcium Isotopic Composition and Its Association With Multiple Myeloma Disease Activity

Diagnostic Imaging of the Lumbar Spine

Letters and Corrections15 February 1990Diagnostic Imaging of the Lumbar SpineWilliam T. Pochis, MD, Arthur Z. Krasnow, MD, B. David Collier, MDWilliam T. Pochis, MDSearch for more papers by this author, Arthur Z. Krasnow, MDSearch for more papers by this author, B. David Collier, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-4-310 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Deyo and colleagues (1) recently reviewed the use of diagnostic imaging procedures for evaluation of the lumbar spine. Radionuclide bone imaging was described as being most useful for the early detection of metastatic cancer or spinal infections and having a limited application in the investigation of low back pain. Such has not been the experience at the Affiliated Hospitals of the Medical College of Wisconsin. At our institution, investigation of chronic low back pain is one of the commonest indications for bone scanning.The use of skeletal scintigraphy in the evaluation of low back pain has been...