Early Detection Of High Risk Research Articles

Assessing peptic ulcer risk with the HAMPROW score in the general Chinese population

The timely identification of individuals at high risk for peptic ulcers (PUs) is vital in preventing gastrointestinal bleeding after antiplatelet therapy. This study was designed to determine PU risk factors and develop a risk assessment model for PU detection in the general Chinese population. In a prospective dataset, clinical data from individuals undergoing gastroscopic evaluation between April 2019 and May 2022 were recorded. PUs were defined as mucosal defects exceeding 5 mm confirmed via gastroscopy. Participants were categorized into development (April 2019 to April 2021) and validation (May 2021 to May 2022) sets based on chronological order. LASSO-derived logistic regression analysis was employed to create a score, which was further validated via temporal validation. A total of 902 patients were ultimately enrolled, 204 (22.6%) of whom had PUs based on endoscopic findings. In the development cohort (n = 631), seven independent risk factors emerged: male sex (OR = 2.35, P = 0.002), white blood cell (WBC) count (OR = 1.16, P = 0.010), red blood cell (RBC) count (OR = 0.49, P < 0.001), globulin level (OR = 0.92, P = 0.004), albumin level (OR = 0.94, P = 0.020), pepsinogen I (PGI) level (OR = 1.01, P < 0.001), and positive Helicobacter pylori (HP) antibody (OR = 2.50, P < 0.001). Using these factors, a nomogram (HAMPROW score [hazard ratio (HP) antibody, albumin, male, PGI, RBC, globulin, and WBC]) was developed for individual PU prediction. The ability of the HAMPROW score to predict survival was confirmed with AUCs of 0.854 (95% CI 0.816–0.891) and 0.833 (95% CI 0.771–0.895) in the development and validation sets, respectively. In conclusion, the HAMPROW score can be used to screen for PUs effectively in the general Chinese population, facilitating personalized early detection of high risk of gastrointestinal bleeding before antiplatelet therapy.

ASUHAN KEBIDANAN KOMPREHENSIF PADA NY.N DI WILAYAH PUSKESMAS PEKAUMAN BANJARMASIN

According to the Indonesian Demographic and Health Survey (IDHS) 2017, the Maternal Mortality Rate (MMR) related to pregnancy, childbirth and the postpartum period is 265 per 100,000 live births, while the infant mortality rate is 27 per 1,000 live births. Number of live and active babies born. In reducing MMR and IMR, as well as preventing complications in pregnancy and childbirth, early detection of high risk is very necessary with the support of quality services and other events such as counseling, classes for pregnant women and comprehensive care. Objective: To carry out comprehensive midwifery care for Mrs. H from pregnancy to family planning. Research method: This research is a case study by understanding the condition of the client and the problems faced by Mrs. P 22 years G1P0A0 UK 33 weeks, conducted in October 2020-January 2021, data collection namely observation, interviews, measurements and documentation using a case study instrument in the form of the SOAP midwifery care format. Results: Based on the assessment during pregnancy, Mrs. P is normal and has no complaints. Evaluation of the client in good and normal condition. Smooth delivery. The baby was born normal, during the visit no problems were found. Uterine involution is normal and there are no complaints. KB care for Mrs. P plans to take lactation pills. The care provided is in accordance with the standard of care

Faktor yang Berhubungan dengan Pengetahuan Ibu Hamil tentang Deteksi Risiko Tinggi Kehamilan

Background: High-risk pregnancy is a major factor in increasing the Maternal Mortality Rate(MMR) and Infant Mortality Rate(IMR) in Indonesia. It’s known high-risk early detection can be a planning solution for pregnancy and childbirth according to the level of risk, because knowledge has a relationship with high-risk pregnancies. The purpose of this study was to determine of level knowledge a pregnant women and analyze factors related to the knowledge of pregnant women about detecting high-risk pregnancies in the working area of Soppeng District Health Center. Method:Using a descriptive analytic research design approachcross-sectional and accidental sampling for techniques. The population in this study was 904 with of 90 sampel of pregnant women in area of Soppeng District(PHC of Batu-Batu, Cangadi, Cabenge, Sewo, Malaka and Takalala). Results:The distribution dominated of respondents was 20-35 years(81.1%), 3rd trimester gestational age(56.7%) and multigravid (67.8%), 38.9% had the SHS level, and 88.9% worked as hausewife. Of all the respondents 42.2% had good knowledge. Conclusion:The level of knowledge of pregnant women in area of Soppeng District Heatlh Center majority have well (42.2%). This is influenced by factors of age, education, work, age pregnancy and parity. Suggestion:It’s hoped that various parties will make efforts to prevent and promote health so as to reduce the number of high-risk pregnancies and other reproductive health problems.

Midwives Complience, Mother And Child Health Book, And Mother’s Health

The Maternal and Child Health Book (MCH Handbook) contains maternal (pregnant, childbirth and postpartum) health records and children (newborns to 6 year old children) as well as various information on how to maintain and care for the health of mothers and children. Based on the 2012 Indonesia Demographic Health Survey (IDHS), the maternal mortality rate (related to pregnancy, childbirth and childbirth) was 359 per 100,000 live births. This study aims to determine the compliance of the MCH handbook by midwives in early detection of high risk of pregnancy in the Kasihan 1 Health Center, Bantul Regency. This study used a descriptive quantitative research design. The variable in this study consisted of one variable, namely compliance with the book of MCH handbook by Midwife in early detection of high risk of pregnancy. The sampling technique in this study was total sampling, with a sample of 9 midwives. The results showed that the compliance of midwives in completing MCH handbooks at the Puskesmas Kasihan 1 Bantul District was mostly obedient with 6 KIA midwives with a percentage of 66.7% and not complying with 3 midwives with a percentage of 33.3%. The suitability of midwives in filling MCH books at the Puskesmas Kasihan 1 Bantul Regency was mostly according to 41 MCH books with a percentage of 68.3% and not according to 19 MCH books with a percentage of 31.7%. The next researcher is expected to be able to conduct a complete research thoroughly the factors that influence the completeness of the MCH handbook by observing and interviewing midwives.

Polish adaptation of the Prodromal Questionnaire-Brief version PQ-B(PL) in psychiatric patients and healthy persons.

Cognitive and affective experiences considered typical of psychotic disorders may also occur in the general population,though in aless severe form. The ability to differentiate them from prodromal states, preceding the onset of full-blown psychosis, is an important element of prevention and early detection of high risk of asudden deterioration of mental state. In response to the current lack of questionnaire tools enabling assessment of psychotic-like experiences (PLEs), an attempt was made to adapt the PQ-B questionnaire for use in the Polish population. In the pilot study, a sample of 652 persons (66% women), aged 18-78 years, approximately 10% of whom were psychiatric patients, completed the Polish version of the PQ-B, and the O-LIFE, HCL-33, SWLS and TCT-DP measures. Results yielded a one-factor structure, satisfactory reliability (α > 0.85) and construct validity of the 21-item self-report questionnaire assessing the incidence of PLEs in the past month and severity of accompanying distress. Furthermore, there were significant correlations between PQ-B scores and symptoms of schizotypy (especially unusual perceptual experiences and cognitive disorganization), emotional lability (p < 0.05) and depressed mood (p > 0.001) typical of hypomania, as well as unconventional thinking (p > 0.05). The PQ-B(PL) can be a useful tool in both Polish clinical practice and scientific research, filling the existing gap among screening tests for traits on the border of health and psychopathology.

Efektifitas Kelengkapan Pendokumentasian Buku KIA untuk Deteksi Resiko Tinggi Kehamilan

The Maternal and Child Health Book (KIA) is a form of family and community active participation in the field of maternal and child health. The successful application of the MCH Handbook as a tool to increase the coverage of MCH services is inseparable from the role of the parties related to the health of pregnant women, mothers in labor, newborns, infants and toddlers. The MCH Handbook has several uses, among others, as a guide for mothers and children to contain information and records on maternal and child health, and the MCH handbook serves as the only means of recording maternal and child health. This study aims to analyze the completeness of documenting pregnant women data from the MCH Handbook at the Pekalongan City Health Center. This research was conducted using a combination of quantitative and qualitative research methods (mixed methodology). Quantitative research uses survey research methods and a cross sectional approach, where the variables are measured at the same time. The population in this study was the KIA book, while the samples in this study were midwives who were serving at the Puskesmas with a minimum work period of 1 year and pregnant women who were having their pregnancies examined, the sample size was determined by the incidental sampling method and purposive sampling based on the health center used. The test results with logistic regression obtained p value &lt;0.05 and the value of Exp (B) ≥ 2 is the variable of tenure. The working period variable has a p value of 0.095, the value of Exp (B) is 10.0 (OR ≥ 2), while the history variable does not have a p value &lt;0.05, namely with a p value of 0.341, the value of Exp (B) is 3.0. So it can be concluded that there is no effect of working period and history together on the completeness of the MCH book documentation for early detection of high risk in pregnancy. Midwives at the Pekalongan City Health Center are advised to further improve the completeness of the MCH Handbook in the early detection of high-risk pregnant women. Increase motivation to midwives by rewarding midwives who have performed their duties well.

UPAYA PENINGKATAN PENGETAHUAN DAN SIKAP KADER POSYANDU DALAM DETEKSI DINI FAKTOR RESIKO KEHAMILAN

Abstract: Early detection of high risk of pregnancy can reduce maternal mortality. The introduction of risk factors in pregnant women is carried out proactively by health workers or trained personnel in the community such as cadres. Padang Community Health Center has 9 posyandu with the total number of active cadres 43 people, coverage coverage of high risk pregnant women by 2015 cadres is 2 people (2.50%). This study aims to determine the effect of efforts to increase knowledge and attitude of posyandu cadres in early detection of pregnancy risk factors. This research uses quasy experimental method with one group pre-post test design. The sample of this research is all posyandu cadres in working area of Padang Serai Community Health Center is 43 people. The result of bivariate analysis with paired t-test showed significant difference of knowledge and attitude of respondent before and after intervention. Ie on pretest-posttest1 knowledge p = 0.000 &lt;0.05, pretest-posttest2 p = 0,000 &lt;0.05, on posttest-posttest2 p = 0.007 &lt;0.05. On the attitude of pretest-posttest1 value p = 0.000 &lt;0,05, pretest-posttest2 p = 0,000 &lt;0,05, on posttest-posttest2 p = 0.000 &lt;0,05, indicate that there is influence of effort to increase knowledge and attitude of posyandu cadre in detection Early pregnancy risk factors.Keywords : knowledge, attitudes, early detection of risk factors for pregnancy.

Effects of Electronic Technology Antenatal Care (E-ANC) on Midwives and Pregnant Women during the COVID-19 Period

BACKGROUND: Pregnant women are considered as a risk group for exposure to COVID-19. Changes in their hormones and immune systems possibly influence their rate of infection by several viruses, including the coronavirus. This stresses the need to observe necessary precautions, by maintaining social distancing, avoiding crowds, and staying at home. Furthermore, the condition also influences the scope of pregnant women’s antenatal visits.&#x0D; AIM: The study aims to determine the effect of COVID-19 on antenatal visits by pregnant women. Furthermore, it seeks to ascertain the effect of electronic technology antenatal care (e-ANC) on the enhanced participation of midwives and pregnant women in antenatal care (ANC) (i.e., counseling, high-risk early detection on pregnancy, and monitoring of Hb and Fe tablets). Therefore, the impact COVID-19 on women’s reproductive health during the pandemic is also evaluated.&#x0D; METHODS: This research involved pre- and post-test experiments on 30 pregnant women and 20 midwives at areas around the Public Health Centers in Tinggiede and Marawola. A purposive sampling technique was adopted, and the results were analyzed using a paired t-test.&#x0D; RESULTS: The study showed discrepancies in the ANC visits of pregnant women before and after the COVID-19 lockdown period, with p &lt; 0.00. Furthermore, there were also differences in midwife participation in counseling by p &lt; 0.00, high-risk early detection on pregnancy by p &lt; 0.001, Hb monitoring by p &lt; 0.002, and provision of Fe tablets by p &lt; 0.003 during the pandemic. Moreover, the pregnant women showed variations in the frequency of counseling by p &lt; 0.00, high-risk early detection on pregnancy by p &lt; 0.00, Hb monitoring by p &lt; 0.002, and the provision of Fe tablets by p &lt; 0.003. The e-ANC instigated a decline in reproductive health problems before (73.4%) and after (10.0%) the intervention.&#x0D; CONCLUSION: The lockdown period influences the low antenatal visits of pregnant women. However, e-ANC for midwives and pregnant women is developed as an alternative solution to improve ANC (i.e., counseling, high-risk early detection, and monitoring Hb and Fe tablets). This consequently has an effect on the reduced reproductive health problems of pregnant women during the pandemic.

Exploration of High Risk Pregnancy Early Detection Model for Cadre in the Working Area of Rasimah Ahmad Public Health Center Bukittinggi, West Sumatera Province, Indonesia

The decreasing number of MMR and IMR can be achieved if the number of high-risk pregnant women decreases. To anticipate this, an approach should be made through individuals who are closest to the community to provide information about high-risk pregnancies such as health cadres. However, cadres&amp;#39; knowledge and attitudes regarding their roles and duties as assistants for high-risk pregnant women and early detection of high risk are still very low. Therefore, it is necessary to increase the knowledge and attitude of health cadres by using appropriate and effective learning media sources in accordance with their knowledge and needs. The general purpose of this study is to explore and identify the perspectives and experiences of health cadres in providing assistance to high-risk pregnant women. The study uses the qualitative research method . It was conducted in the working area of Rasimah Ahmad Bukittinggi Health Center in July - October 2018. The subjects of this study consisted of health cadres, KIA program designers, and policy makers. The data were collected by using in Depth Interview and Focus Group Discussion. They were analyzed by using interactive analysis method.The result of the study shows that there is still a lack of knowledge of cadres regarding their roles and duties as assistants for high-risk pregnant women and early detection of high risk of pregnancy. This is due to the absence of handbook for cadres in providing information / and counseling to regnant women other than the KIA books they have been using and the experiences they have gained so far. The conclusion of this study is there is lack of learning media sources for cadres in providing services to pregnant women. Hence, the learning media resources are urgently needed as a reference in giving quality assistance.

The independence of pregnant women in early detection of high risk of pregnancy in terms of parity, knowledge and information exposure

The ability of pregnant women to detect early of a high risk pregnancy is still below the average which is one of the causes of complications that can endanger the wellbeing of the mother and fetus. The purpose of this study is to determine the relationship between factors of parity, knowledge and exposure to information on the independence of mothers in early detection of the risk of pregnancy. This type of analytic observational research uses a cross sectional design. A total sample of 125 pregnant women was chosen by “Stratified Random Sampling” technique. The results of Multiple Logistic Regression Analysis show that the knowledge variable Exp (B) 6.657 is a significant variable, the exposure to danger information variable Exp (B) 7.657 is a significant variable and the parity variable Exp (B) 8.060 is also a significant variable. Midwives and health workers further increase counseling so that pregnant women and families can receive more information about the danger signs of pregnancy, especially the high risk of pregnancy and being able to do early detection.

DNA damage response genes mark the early transition from colitis to neoplasia in colitis-associated colon cancer

Chronic intestinal inflammation predisposes patients with Inflammatory Bowel Disease (IBD) to Colitis-Associated Cancer (CAC). In the setting of chronic inflammation, microsatellite instability (MSI) results from early loss of DNA damage response (DDR) genes, ultimately leading to tumor formation. Despite continued efforts to improve early detection of high risk, pre-dysplastic regions in IBD patients, current macroscopic and genetic surveillance modalities remain limited. Therefore, understanding the regulation of key DDR genes in the progression from colitis to cancer may improve molecular surveillance of CAC. To evaluate DDR gene regulation in the transition from colitis to tumorigenesis, we utilized the well-established Azoxymethane/Dextran Sodium Sulfate (AOM/DSS) pre-clinical murine model of CAC in C57BL/6 mice. In order to assess colonic tumor burden in the setting of mutagen and intestinal irritation, tumors were visualized and graded in real time through high-resolution murine colonoscopy. Upon sacrifice, colons were opened and assessed for macroscopic tumor via high magnification surgical lenses (HMSL). Tissues were then sectioned and separated into groups based on the presence or absence of macroscopically visible tumor. Critical DDR genes were evaluated by semi-quantitative RT-PCR. Interestingly, colon tissue with macroscopically visible tumor (MVT) and colon tissue prior to observable tumor (the non-macroscopically visible tumor-developing group, NMVT) were identical in reduced mRNA expression of mlh1, anapc1, and ercc4 relative to colitic mice without mutagen, or those receiving mutagen alone. Colitis alone was sufficient to reduce colonic ercc4 expression when compared to NMVT mice. Therefore, reduced ercc4 expression may mark the early transition to CAC in a pre-clinical model, with expression reduced prior to the onset of observable tumor. Moreover, the expression of select DDR genes inversely correlated with chronicity of inflammatory disease. These data suggest ercc4 expression may define early stages in the progression to CAC.

Hubungan Keteraturan Ibu Hamil Dalam Melaksanakan Kunjungan Antenatal Care (ANC) Terhadap Hasil Deteksi Dini Risiko Tinggi Ibu Hamil di Poli KIA RSUD Gambiran Kota Kediri

Each pregnancy can develop normally, but it is difficult to know before that the pregnancy would be a problem, Antenatal care is an important way to monitor and support the normal maternal health and to detect any abnormalities in normal pregnancy. This study aims to determine the correlation of Pregnant mother’s Regularity in visiting Antenatal Care (ANC) on the Results from Early Detection of High Risk Pregnancy in Poli KIA RSUD Gambiran Kediri. This research is analytic correlation using a case-control study design. The populations in this study were all third trimester pregnant mother with high risk in Poli KIA RSUD Gambiran Kediri. The number of samples is 28 people who were taken with simple random sampling technique. Measuring instruments used KIA books and Antenatal care documentation. The results will be analyzed using Chi Square test with one sample with a standard error 5% (0,05). Based on the analysis results obtained values � = 14,28 ; 3,841 so it can be stated that there is the correlation of Pregnant mother’s Regularity in visiting Antenatal Care (ANC) on the Results from Early Detection of High Risk Pregnancy in Poli KIA RSUD Gambiran Kediri. The results are mostly high-risk pregnant mother are irregular in implementing Antenatal care. The recommendations of this research is needed to conduct counseling from a health counselor to all pregnant mother about the importance of prenatal care regularly to add the knowledge about pregnancy and also to allows health workers to detect early if there is a complication of pregnancy and as an effort to increase utilization of health services for mother pregnant.; Key words : regularity of ANC, Antenatal Care (ANC), Early Detection of High Risk

Analisis Perilaku Ibu Hamil Dalam Deteksi Dini Risiko Tinggi Kehamilan Dengan Integrated Behavioral Model Di Kota Banjarmasin

High risk pregnancy factors need to be considered since they could lead to obstetric complications which could lead to death of the pregnant woman. This study was a cross sectional study, with samples of 300 respondents of pregnant women in their trimesters in the city of Banjarmasin, using logistic regression analysis with 5% level of significance (α = 0.05).Analysis of the behavior of the mother in the early detection of high risk based on integrated behavioral models in the city of Banjarmasin, showed the following results: experiential attitude and instrumental attitude influenced the intention to perform the behavior, which could be in seen the p-value of the statistical tests carried out. For experiential attitude, the p = 0.000 (p <0.05) had the influence of 25 times or OR as many as 25.506. and instrumental attitude was at p = 0.000 (p <0.05), had the influence as much as 6 times or OR 6.769. Perceived norm had several elements: injuntivenorm, had an influence on the intention to perform the behavior, which could be seen from p = 0.000 (p <0.05) which meant that it had a significant influence and the influence was equal to 12 times (OR 12.364). Pregnant women in the early detection of high risk, was strongly influenced by the behavior of pregnant women themselves. So as to make that pregnant women have good behaviors, particularly in the early detection of high risk pregnancy, it is expected that to improve the ability of pregnant women, both with increased knowledge and skills through giving information to pregnant women concerning to early detection of high-risk pregnancies and with the health services provided. Keywords : behavior, early detection of high risk pregnancies, pregnant wome n

Can melatonin regulate the expression of prohormone convertase 1 and 2 genes via monomeric and dimeric forms of RZR/ROR nuclear receptor, and can melatonin influence the processes of embryogenesis or carcinogenesis by disturbing the proportion of cAMP and cGMP concentrations? Theoretic model of controlled apoptosis

The presented model of controlled apoptosis has been based on the assumption that correct information exchange between an organism as a whole, and each of its cells is conditioned by mutual proportions of cAMP and cGMP concentrations (C cAMP, C cGMP), according to the formula C cAMP× C cGMP= ‘a’ (constant). The regulation of balance of these ‘second messengers’ in a cell and an extracellular space would depend on the mutual proportions of concentrations of Melatonin and monomers of Melanin. These indoloderived compounds could be the activators of the transcription factors i.e. RZR and NFkappa-B, regulating the expression of Prohormone Convertase (PC) gen and Nitric Oxide Synthase (NOS) gen, respectively. Additionally, maternal Melatonin and Nitric Oxide (NO), being able to pass through trophoblast or placenta freely, would play decisive role in the synchronization of embryogenesis and intrauterine development of the fetus. In case of an embryo or a fetus, the result of C cAMPand C cGMPmultiplication, different from the proper constant ‘a’-value, would mean occurrence of disorders in the structure and functioning of the cellular tensegrity system and, in consequence, disturbances in the intercellular information exchange. It would lead to deviation in cellular metabolism, oriented cell movement, uncontrolled apoptosis, and as a consequence, would lead to the development of fetal defects. In case of a child or an adult, a sudden occurrence and prolongation of such disturbances in C cAMP–C cGMPproportions would induce a process of apoptosis of normal cells and an initiation of a cancerogenesis. On the other hand, the recovery of equilibrium in the information exchange system would initiate apoptosis of neoplastic cells, and simultaneously, proliferation of connective tissue cells. According to the presented hypothesis, a decrease in C cAMPand destabilization of the C cAMP–C cGMPbalance in an embryo or a fetus would result from relatively excessive amounts of maternal Melatonin (monomers) in fetal circulation, while a decrease of C cAMPand destabilization of the C cAMP–C cGMPbalance in a child or an adult would be a consequence of relatively insufficient amounts of Melatonin (dimers) in an organism. It seems possible, that determination of both C cAMPand C cGMPwould enable an early detection of high risk of developmental defects occurrence in an embryo or a fetus and neoplastic processes in a child or an adult. This method might also be considerably useful in monitoring a safe substitutional hormonotherapy. Copyright 2001 Harcourt Publishers Ltd INTRODUCTION