The objective of this paper is to examine the moderating effect of information literacy between supply-demand factors and the effectiveness of e-government. Particularly, the present study aimed to ascertain whether information literacy moderates the effect of web security, political trust and social influence on the frequency of use and perceived usefulness of government websites in Malaysia. This research employed a quantitative methodology using a survey data amongst 178 adults in Malaysia. Hypotheses were tested through two levels of ordinary least squares regression models. The results showed that social influence is positively related with both frequencies of use and perceived usefulness. However, web security was associated only with the former whilst political trust was associated only with the latter. Lastly, we found a weak relationship between information literacy and the frequency of use. Overall, this paper tested on a comprehensive model of supply-demand factors on a broader perspective of e-government effectiveness amongst users.