In all likelihood, Rome was the first global city, holding such primacy for around two thousand years since the time when the Empire built strong integration and interdependence relationships with the whole oecumene. Against the backdrop of long-term beliefs powered by the Papacy, this paper highlights the main features of the global Rome as the very core of Christianity and, after several disruptive events from the Early Renaissance onwards, as a main destination of the Grand Tour. Making use of primary and secondary literature sources as well as of a substantial iconography, the paper investigates the interplay between power strategies and urban morphology—permanence/change—through two main lenses: (i) the ‘inertia’ over time of the radiocentric pattern of the Forma Urbis citywide, according to the old saying all roads lead to Rome; and, (ii) the relentless reuse processes over built-up areas and sense-making dynamics coupling tangible and intangible assets. Accordingly, the Città Antica and the Città Moderna would be intertwined in residents’ and visitors’ everyday experiences until the Age of Enlightenment, when a new sense of history was to require protection measures setting antiquities apart from city life. However, this is another story.
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