Dynamics Of Heart Rate Variability Research Articles

Characterization of heart rate variability in end-stage renal disease patients after kidney transplantation with recurrence quantification analysis.

Heart rate variability (HRV) is a noninvasive approach to studying the autonomic modulation of heart rate in experimental settings, such as active standing sympathetic stimulation. It is known that patients with end-stage renal disease during active standing have few changes in HRV dynamics, which are improved after hemodialysis. However, it is unknown whether the response to active standing is recovered after definitive treatment with kidney transplantation. This work aims to assess the change in HRV dynamics in the supine position and active standing through time and frequency-based metrics, as well as recurrence plot quantitative analysis (RQA). We studied HRV dynamics by obtaining 5-minute electrocardiographic recordings from kidney transplant recipients who underwent an active standing test. The mean duration of heartbeats and their standard deviation diminished in active standing, compared with the supine position. Also, the low-frequency component of HRV and the presence of diagonal and vertical structures in RQA were predominant. A larger estimated glomerular filtration rate was significantly correlated with broader HRV in the supine position and during active standing. The narrower HRV during active standing may indicate a sympathetic response to external stimuli, which is expected in a functional cardiovascular system, and may be influenced by renal function.

Chronic effect of resistant physical exercise on linear and nonlinear dynamics of heart rate variability in patients with type 2 diabetes mellitus

Introduction: Diabetes Mellitus (DM) can promote changes in the autonomic nervous system. Training with resistance exercise can contribute to the decrease of the glycemic level and improve the neural control of the heart. Objective: to verify the effects of resistance exercise training (RT) on linear and non-linear dynamics of autonomic heart rate (HR) modulation in patients with DM2. Methods: Eight patients with DM2 were studied. The R-R intervals of the HR were recorded in the supine resting condition and HRV was analyzed by linear and non-linear method. RT was performed for 12 weeks, with 60% 1RM, 5 exercises for large muscle groups. Results: data variations between post-RT and initial ones did not show statistical difference (p>0.05) in HRV calculated both by linear and non-linear methods. Conclusion: 12 weeks of moderate RT does not promote positive effects on HRV in patients with T2DM.

Comparison of the effects of dexmedetomidine and propofol on the cardiovascular autonomic nervous system during spinal anesthesia: preliminary randomized controlled observational study

Spinal anesthesia induces sympatholysis and is usually combined with dexmedetomidine or propofol which induce different hemodynamic changes. The purpose of this study was to compare the effect on autonomic nervous system between dexmedetomidine and propofol combined with spinal anesthesia. Patients aged 20–65 undergoing elective surgery under spinal anesthesia were randomly assigned to dexmedetomidine or propofol group. Heart rate variability (HRV) and hemodynamic variables were measured at four time points: T0, baseline; T1, 10 min after spinal anesthesia; T2, 10 min after sedative administration; and T3, 20 min after sedative administration. In 59 patients, dexmedetomidine and propofol groups had significantly different hemodynamic changes over time (time × group effect P < 0.001). The dexmedetomidine group had slower heart rate at T2 (P = 0.001) and higher blood pressures at T2 and T3 (P < 0.001) than the propofol group. Overall HRV dynamics showed a significant change over time from T0 to T3, but both groups exhibited similar trends. Compared to the baseline data within the group, the low frequency (LF) decreased in both groups but the decrease occurred at T2 in the propofol group and at T3 in the dexmedetomidine group. The high frequency (HF) increased at T2 and T3 only in the dexmedetomidine group. The LF/HF ratio decreased in the dexmedetomidine group at T3. Dexmedetomidine showed slower heart rate and higher blood pressure than propofol when combined with spinal anesthesia, however, dexmedetomidine and propofol exhibited similar trends in HRV dynamics. Compared with the baseline within each group, both agents decreased LF, but only dexmedetomidine increased HF and decreased in the LF/HF ratio significantly.

Symbolic dynamics of sleep heart rate variability is associated with cognitive decline in older men.

We aimed to investigate the association between autonomic and cognitive functions in older men. We investigated heart rate variability (HRV) during sleep using time domain metrics and symbolic dynamics analysis of inter-beat intervals. These metrics were statistically analysed for associations with cognitive function which was elicited by administering the modified mini-mental state examination (3MS) and the Trail making test part-B in older men participating in the MrOS sleep study.Multivariable linear regression adjusted for age, body-mass-index (BMI), apnea-hypopnea index (AHI) and arousal index (A.I.) showed that symbolic dynamics of HRV especially the 0V% which is a measure of sympathetic outflow to the heart during rapid eye movement (REM) sleep is significantly associated with 3MS and Trail B scores. In conclusion, nonlinear HRV during sleep provides a unique window to probe the association between cognitive and autonomic function.Clinical Relevance- This study shows that cognitive decline is associated with altered cardiac autonomic function.

Adynamic response to cold pain reflects dysautonomia in type 1 diabetes and polyneuropathy

Cardiac autonomic neuropathy (CAN), widely assessed by heart rate variability (HRV), is a common complication of long-term diabetes. We hypothesized that HRV dynamics during tonic cold pain in individuals with type 1 diabetes mellitus (T1DM) could potentially demask CAN. Forty-eight individuals with long-term T1DM and distal symmetrical polyneuropathy and 21 healthy controls were included. HRV measures were retrieved from 24-h electrocardiograms. Moreover, ultra-short-term HRV recordings were used to assess the dynamic response to the immersion of the hand into 2 °C cold water for 120 s. Compared to healthy, the T1DM group had expectedly lower 24-h HRV measures for most components (p < 0.01), indicating dysautonomia. In the T1DM group, exposure to cold pain caused diminished sympathetic (p < 0.001) and adynamic parasympathetic (p < 0.01) HRV responses. Furthermore, compared to healthy, cold pain exposure caused lower parasympathetic (RMSSD: 4% vs. 20%; p = 0.002) and sympathetic responses (LF: 11% vs. 73%; p = 0.044) in the T1MD group. QRISK3-scores are negatively correlated with HRV measures in 24-h and ultra-short-term recordings. In T1DM, an attenuated sympathovagal response was shown as convincingly adynamic parasympathetic responses and diminished sympathetic adaptability, causing chronometric heart rhythm and rigid neurocardiac regulation threatening homeostasis. The findings associate with an increased risk of cardiovascular disease, emphasizing clinical relevance.

Nonlinear Dynamics of Heart Rate Variability after Acutely Induced Myocardial Ischemia by Percutaneous Transluminal Coronary Angioplasty.

Several heart rate variability (HRV) characteristics of patients with myocardial ischemia are associated with a higher mortality risk. However, the immediate effect of acute ischemia on the HRV nonlinear dynamical behavior is unknown. The objective of this work is to explore the presence of nonlinearity through surrogate data testing and describe the dynamical behavior of HRV in acutely induced ischemia by percutaneous transluminal coronary angioplasty (PTCA) with linear and recurrence quantification analysis (RQA). Short-term electrocardiographic recordings from 68 patients before and after being treated with elective PTCA were selected from a publicly available database. The presence of nonlinear behavior was confirmed by determinism and laminarity in a relevant proportion of HRV time series, in up to 29.4% during baseline conditions and 30.9% after PTCA without statistical difference between these scenarios. After PTCA, the mean value and standard deviation of HRV time series decreased, while determinism and laminarity values increased. Here, the diminishment in overall variability caused by PTCA is not accompanied by a change in nonlinearity detection. Therefore, the presence of nonlinear behavior in HRV time series is not necessarily in agreement with the change of traditional and RQA measures.

Функциональное состояние педагогов северного университета при переходе к дистанционному формату работы

The purpose of this paper was to perform a comprehensive study of the functional state of male and female teachers of a northern university during the quarantine due to the coronavirus pandemic, when they had to switch from on-campus to distance teaching. Materials and Methods. The study involved 56 teachers (36 men and 20 women) from Surgut State Pedagogical University, who were examined before and after the switch to distance teaching. The functional state of the central nervous system (CNS) was evaluated according to the data of simple visual-motor reaction. The state of autonomic regulation was characterized based on the dynamics of heart rate variability at rest and during active orthostatic test. Peripheral systolic and diastolic blood pressure and central systolic aortic pressure were measured. The psychophysiological state was analysed using the Maslach Burnout Inventory and Eysenck’s “Self-assessment of anxiety, frustration, aggressiveness and rigidity”. The quality of life was evaluated using the Short Form (36) Health Survey. Results. During on-campus teaching, female university teachers showed more pronounced impairments of autonomic regulation and functional state of the CNS compared to their male colleagues. In addition, women experienced professional burnout more often, while an increase in central and peripheral blood pressure was less common among them. After the transition from on-campus to distance teaching during the COVID-19 quarantine, functional disorders of autonomic hear rate regulation and haemodynamics were more pronounced in men than in women. Women under the same conditions had greater impairments of the functional state of the CNS, while demonstrating improvements in the psychophysiological state. Thus, the research found that changes in the form of teaching produce different effects on the functional state of male and female university teachers.

Detection of Meditation-Induced HRV Dynamics Using Averaging Technique-Based Oversampled Feature Set and Machine Learning Classifiers

In this paper, we propose a textural information-based analysis of scalogram image obtained from continuous wavelet transform of heart rate variability (HRV) signal to study its dynamics during meditation. In addition to features from scalogram image, visibility graph-based complexity measures and multiscale permutation entropies (MPEs) from HRV signal are used to elucidate the modulation in autonomic activity of heart during meditative and non-meditative state. Significant changes in the probability distribution of pixel intensities of scalogram image and undiminished permutation entropy at higher scales are observed during the meditative state. From the extracted features, we have selected the top-ranked features based on ReliefF algorithm and minimum threshold weight of importance set at 0.04. Considering the small sample size (12 subjects) of meditation dataset, we have employed a novel data augmentation technique based on averaging of feature sets to overcome the issue of overfitting. To examine the efficacy of the proposed technique, both the non-augmented and augmented data are applied to four different types of classifiers, namely k-nearest neighbor, support vector machine (SVM), logistic regression and random forest classifiers. Experimental results demonstrate that performance of classifiers in distinguishing meditative and pre-meditative state are much superior with the augmented data as compared to that with regular non-augmented data. Out of these classifiers, radial basis function (RBF)-based SVM results in the best performance with an average accuracy of 96.67%, sensitivity of 95.83% and specificity of 97.5%.

Pulmonary Effects of One Week of Repeated Recreational Closed-Circuit Rebreather Dives in Cold Water.

Background and Objectives: The use of closed-circuit rebreathers (CCRs) in recreational diving is gaining interest. However, data regarding its physiological effects are still scarce. Immersion, cold water, hyperoxia, exercise or the equipment itself could challenge the cardiopulmonary system. The purpose of this study was to examine the impact of CCR diving on lung function and autonomous cardiac activity after a series of CCR dives in cold water. Materials and Methods: Eight CCR divers performed a diving trip (one week) in the Baltic Sea. Spirometry parameters, SpO2, and the lung ultrasonography score (LUS) associated with hydration monitoring by bioelectrical impedance were assessed at the end of the week. Heart rate variability (HRV) was recorded during the dives. Results: No diver declared pulmonary symptoms. The LUS increased after dives combined with a slight non-pathological decrease in SpO2. Spirometry was not altered, and all body water compartments were increased. Global HRV decreased during diving with a predominant increase in sympathetic tone while the parasympathetic tone decreased. All parameters returned to baseline 24 h after the last dive. Conclusions: The lung aeration disorders observed seem to be transient and not associated with functional spirometry alteration. The HRV dynamics highlighted physiological constraints during the dive as well as environmental-stress-related stimulation that may influence pulmonary changes. The impact of these impairments is unknown but should be taken into account, especially when considering long and repetitive CCR dives.

Heart rate variability in patients with insomnia disorder: a systematic review and meta-analysis.

Though logical inference based on small studies suggests that patients with insomnia have a blunted heart rate variability (HRV), this condition not been clearly shown. This meta-analysis aimed to determine whether or notHRV was impaired in patients withinsomnia. We conducted a comprehensive literature search for studies that examined the association of HRV with insomnia disorder. HRV measures were extracted using the SDNN (time-domain measure, i.e., standard deviation of all NN intervals,) or the HF-norm (frequency-domain measure, i.e., high-frequency power normalized using total power). The effect size estimates of R_equivalent obtained from p values and sample size were synthesized. We identified 17 studies with 921 participants. The pooled R_equivalent was 0.19 with 95% CI of 0.12 and 0.25 (p < 0.001), and there was no significant heterogeneity (I2 = 0.0%, p = 0.809). A p value of 0.075 corresponding to the R_equivalent of 0.19 was obtained, suggesting that blunted HRV was not significant in patients with insomnia disorder. The current evidence did not confirm that HRV was reliably impaired in patients with insomnia disorder. Prospective studies using standard HRV measures are needed to clarify the HRV dynamics in different insomnia subtypes.

Correlation between heart rate variability and polysomnography-derived scores of obstructive sleep apnea.

Obstructive sleep apnea (OSA) is one of the most common sleep disorders and affects nearly a billion people worldwide. Furthermore, it is estimated that many patients with OSA are underdiagnosed, which contributes to the development of comorbidities, such as cardiac autonomic imbalance, leading to high cardiac risk. Heart rate variability (HRV) is a non-invasive, widely used approach to evaluating neural control of the heart. This study evaluates the relationship between HRV indices and the presence and severity of OSA. We hypothesize that HRV, especially the nonlinear methods, can serve as an easy-to-collect marker for OSA early risk stratification. Polysomnography (PSG) exams of 157 patients were classified into four groups: OSA-free (N = 26), OSA-mild (N = 39), OSA-moderate (N = 37), and OSA-severe (N = 55). The electrocardiogram was extracted from the PSG recordings, and a 15-min beat-by-beat series of RR intervals were generated every hour during the first 6h of sleep. Linear and nonlinear HRV approaches were employed to calculate 32 indices of HRV. Specifically, time- and frequency-domain, symbolic analysis, entropy measures, heart rate fragmentation, acceleration and deceleration capacities, asymmetry measures, and fractal analysis. Results with indices of sympathovagal balance provided support to reinforce previous knowledge that patients with OSA have sympathetic overactivity. Nonlinear indices showed that HRV dynamics of patients with OSA display a loss of physiologic complexity that could contribute to their higher risk of development of cardiovascular disease. Moreover, many HRV indices were found to be linked with clinical scores of PSG. Therefore, a complete set of HRV indices, especially the ones obtained by the nonlinear approaches, can bring valuable information about the presence and severity of OSA, suggesting that HRV can be helpful for in a quick diagnosis of OSA, and supporting early interventions that could potentially reduce the development of comorbidities.

SELECTION OF A SIGNIFICANT INDICATOR OF OPERATOR-PILOT TENSION ON THE BASIS OF OBJECTIVE INFORMATION ABOUT HIS CONDITION DURING FIGHT TASKS ON THE SEMI-NATURAL MODELLING COMPLEX

As a significant indicator for assessing the intensity of activity that affects performance, a local assessment was chosen in the form of an index of tension according to R. Baevsky, accumulating the effects of the influence of temporal, statistical and spectral indicators of the heart rate, its variability, followed by modification of the assessment into an integral indicator R as a coefficient body reserve. The peculiarity of the local assessment is that it is a dynamic parameter that characterizes the state of the body at a given point in time, and to obtain it, the Holter technology was used with the formation of digital files of heart rate variability (HRV) indicators recorded by a monitoring system with a set of four clusters each, spaced in time and containing data of implementations of flight tasks of the initial, middle and final phases of the flight. Necessary and sufficient to display the dynamics of HRV was the time duration of the clusters of 300 seconds, which made it possible to obtain the necessary digital content of the HRV parameters in 40…60 minutes of flight time. The informational significance of the data obtained is determined by the content of the implemented flight tasks for various purposes. The capabilities of the semi-natural modeling complex made it possible to create complex and special flight situations, that negatively affect the psycho-physiological state of the operator. Local estimates of the tension index were obtained, which generally fell within the range of acceptable values, although in special cases of flight they went into the range characteristic of the states of effective adaptation of the organism. Levels were also recorded, signaling the exhaustion of the body’s capabilities, fatigue and a reduced level of performance. A generalized integral indicator of tension is proposed – the reserve coefficient of the body R as a linear combination of local estimates of tension: the maximum local intensity index achieved in a given flight cycle, “passport” indicator of the operator’s tension, fixed before the flight task at the stage of pre-flight preparation, and an indicator of the current tension at a particular point in time in a particular situation. At the same time, the smaller the value of R, the smaller the reserve of the organism. The obtained experimental integral estimates of the body reserve in the process of operator activity are not only of research interest, but also of interest in practical applications in the tasks of ergonomic expertise of aviation equipment and the design of the operator-pilot activity.

A personified approach to the treatment of vegetative disorders in patients with prevential stomach conditions using Pure Purr complex

Background. Indicators of heart rate variability are reliable and objective indicators of the tone of the autonomic nervous system (ANS), which reflects changes in the psycho-emotional state of man against the background of stress. Stress management programs include a variety of relaxation techniques and cognitive behavioral therapy. Therefore, the purpose of the study was to optimize the treatment of patients with chronic atrophic gastritis with autonomic disorders using software and hardware for parasympathetic activation of the ANS. Materials and methods. Indicators of heart rate variability were studied in 80 patients with chronic atrophic gastritis based on the results of PRECISE diagnostics, which allowed to identify patients with hypersympathicotonia and treat them with 10 sessions on Pure Purr software and hardware complex to assess the dynamics of heart rate variability. Results. 72.7% of patients with chronic atrophic gastritis, who showed a decrease in heart rate variability due to activation of the sympathetic tonic ANS and insufficient activity of its parasympathetic tonic, breakdown of adaptation, lack of stress and functional reserves of the body were treated with neurostimulation. After treatment, positive dynamics was determined in the form of a significant increase in heart rate variability by increasing its components due to the parasympathetic nervous system, which prevents increased sympathetic influences and improves disease and prognosis by normalizing adaptation, functional reserves and stress resistance. Conclusions. Treatment of patients with chronic atrophic gastritis with autonomic disorders should be comprehensive with the inclusion of hardware with neurostimulation software aimed at reducing hypersympathicotonia with increasing adaptive capacity of the body.

Heart Rate Variability Reveals Altered Autonomic Regulation in Response to Myocardial Infarction in Experimental Animals.

The analysis of beating rate provides information on the modulatory action of the autonomic nervous system on the heart, which mediates adjustments of cardiac function to meet hemodynamic requirements. In patients with myocardial infarction, alterations of heart rate variability (HRV) have been correlated to the occurrence of arrhythmic events and all-cause mortality. In the current study, we tested whether experimental rodent models of myocardial infarction recapitulate dynamics of heart rate variability observed in humans, and constitute valid platforms for understanding mechanisms linking autonomic function to the development and manifestation of cardiovascular conditions. For this purpose, HRV was evaluated in two engineered mouse lines using electrocardiograms collected in the conscious, restrained state, using a tunnel device. Measurements were obtained in naïve mice and animals at 3–∼28 days following myocardial infarction, induced by permanent coronary artery ligation. Two mouse lines with inbred and hybrid genetic background and, respectively, homozygous (Homo) and heterozygous (Het) for the MerCreMer transgene, were employed. In the naïve state, Het female and male mice presented prolonged RR interval duration (∼9%) and a ∼4-fold increased short- and long-term RR interval variability, with respect to sex-matched Homo mice. These differences were abrogated by pharmacological interventions inhibiting the sympathetic and parasympathetic axes. At 3–∼14 days after myocardial infarction, RR interval duration increased in Homo mice, but was not affected in Het animals. In contrast, Homo mice had minor modifications in HRV parameters, whereas substantial (> 50%) reduction of short- and long-term RR interval variation occurred in Het mice. Interestingly, ex vivo studies in isolated organs documented that intrinsic RR interval duration increased in infarcted vs. non-infarcted Homo and Het hearts, whereas RR interval variation was not affected. In conclusion, our study documents that, as observed in humans, myocardial infarction in rodents is associated with alterations in heart rhythm dynamics consistent with sympathoexcitation and parasympathetic withdrawal. Moreover, we report that mouse strain is an important variable when evaluating autonomic function via the analysis of HRV.

Investigation of the Effect of eSport on HRV Signal by Using Poincaré Plot Analysis

In this work, in order to determination of effect of a puzzle video game on HRV (Heart rate variability) signal, Poincare plot analysis is used. The linear and nonlinear dynamics of HRV were evaluated using HRV recordings obtained from each player at the time of play and rest. For this purpose, we have correlated the Poincaré plot descriptors with standard HRV measures derived from time- and frequency-domain methods. In addition, the correlations between the descriptors of the Poincaré plot along with the frequency and time domain measures of HRV have evaluated for the game stage. Statistically significant values were observed in eSport players in gaming and during resting. The obtained results show that play and rest can be separated by using the features obtained from the Poincare plot.

TO STUDY AND CORRELATE THE EFFECT OF INTEGRATED APPROACH OF YOGA THERAPY ON FREQUENCY DOMAIN PARAMETERS AND POINCARE PLOT OF HEART RATE VARIABILITY AMONG PREDIABETICS

Introduction- Prediabetes is demarcated as an intervening stage amongst normal glucose tolerance and type 2 diabetes mellitus. The present study aimed toevaluate the effects ofthe Integrated approach of yoga therapyonlinear andnonlinear dynamics ofheart rate variability and correlate between a linear component that was frequency domainand nonlinear dynamics that was Poine care plotof heart rate variability. Method-The study was conducted in the Department of physiology, Rajasthan University of Health Sciences, Jaipur in association with RDBP Jaipuria hospital.Group A wasinvolved in the Integrated Approach of Yoga Therapy (IAYT)including Prayer, Omkar recitation, yoga postures, breathing techniques, Shavasana,counseling, and dietary modification and Group B was not involved in any yoga sessions. Result-In this study, an attempt has been made to assess specifically the nonlinear dynamics of HRV using Poincare plotafter the integrated approach of yoga therapyand compare it with that of the frequency domain of HRV assessed by linear measures.Thehigh-frequency power( 46.04±11.75 to 67.56± 13.06) and SD1 ( 28.75 ±3.15 to 45.66±2.15) were increased andlow frequency (LF) power ( 66.67±11.87 to 40.67± 13.9) and the SD2 ( 55.76± 1.15 to 44.88 ± 2.15) of the Poincare plot decreased compared to baseline insubjects whofollowedthe integrated approach of yoga therapy, Additionally, significant correlations were found between high frequency (HF) and SD1 (p &lt; 0.05), LF and SD2, (p &lt; 0.05), and LF/HF and SD2/SD1 (p &lt; 0.01). Conclusion-Integrated approach of yoga therapy practiced regularly can emerge as one of the important non-pharmacological tools for primary prevention of cardiovascular disease andrestoring sympathovagal balance. Poincare plot analysis is easier and more sensitive in evaluating the sympathovagal balance and observing the variation in heartbeats.

Influence of Insulin Resistance and Obesity on the Autonomic Regulation of Rat Heart Rate under Conditions of Adequate and Limited Iodine Supply

Cardiovascular diseases remain a major medical problems in most countries around the world, causing significant economic disbenefit. An important pathogenetic mechanism of the influence of insulin resistance and hypothyroidism on the cardiovascular system is the alteration in the autonomic regulation of heart rhythm.&#x0D; Objective. The aim of the study was to evaluate the dynamics of heart rate variability (HRV) in rats with insulin resistance and obesity under the conditions of adequate and limited iodine supply.&#x0D; Materials and Methods. Studies were performed on 90 nonlinear rats pandomized by random sampling. The response of the autonomic nervous system (ANS) was studied using a computer program to analyze HRV “Poly-Spectrum.NET” with the additional module “Poly-Spectrum.NET/Veterinary”.&#x0D; Results. It was determined that the co-directed dynamics of geometric and statistical analysis of HRV and balance shift in the direction of the low-frequency component in spectrum analysis of the heart rate regarding control data were revealed in rats with isolated insulin resistance, obesity and combined endocrinopathy (insulin resistance and obesity under the conditions of limited iodine supply). &#x0D; Conclusion. The prevalence of sympathetic ANS activity under the conditions of insulin resistance and obesity can contribute to cardiac arrhythmias, the development of diabetic autonomic neuropathy and with a high probability to cause some cases of life-threatening arrhythmias (supraventricular and ventricular). Iodine deficiency contributes to the depletion of regulatory effects of ANS and limits the range of adaptive capabilities and resources of the organism.

Experimental Diagnostics of the Emotional State of Individuals Using External Stimuli and a Model of Neurocognitive Brain Activity.

In this paper, we study ways and methods to diagnose the emotional state of individuals using external audiovisual stimuli and heart telemetry tools. We apply a mathematical model of neurocognitive brain activity developed specifically for this study to interpret the experimental scheme and its results. This experimental technique is based on monitoring and analyzing the dynamics of heart rate variability (HRV), taking into account the particular context and events occurring around the subject of the study. In addition, we provide a brief description of the theory of information images/representations used for the paradigm and interpretation of the experiment. For this study, we viewed the human mind as a one-dimensional potential hole with finite walls of different sizes and an internal potential barrier modeling the border between consciousness and subconsciousness. We also provided the foundations of the mathematical apparatus for this particular view. This experiment allowed us to identify the characteristic markers of influencing external stimuli, which form a foundation for diagnosing the emotional state of an individual.

Heart rate variability dynamics in women with urinary incontinence: a systematic review.

Sympathetic and parasympathetic pathways of the autonomic nervous system (ANS) regulate the lower urinary tract. The aim of the present study was to synthesize the evidence regarding ANS regulation in women with urinary incontinence (UI) evaluated through heart rate variability (HRV). This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA) guideline. Five databases were researched in April 2021 (PubMed, CINHAL, Scopus, Web of Science and Cochrane Library) and included cross-sectional studies in full-length publications in the English language. Studies assessed the HRV during bladder filling (group A) and after voiding (group B). The Joanna Briggs Institute (JBI) checklist was applied for methodological quality assessment purposes. A total of 920 articles were identified and 5 studies were included. Most studies analyzed the HRV by linear indexes. Studies from group A (n = 2) presented fair methodological quality; one study from group B (n = 3) showed fair methodological quality (Im et al. Korean J Urol. 51:183, 2010) whereas the others presented high methodological quality. One study from group A found an increase in both modulations between women with overactive bladder (OAB) versus women with stress UI, whereas a decrease was reported between incontinent and continent women. Studies from group B showed a decreased sympathetic and parasympathetic modulation in AOB with detrusor overactivity (DO), whereas one study found an increase in both modulations in women with OAB compared with stress UI. Parasympathetic and sympathetic modulationincreased during bladder filling and rest in UI with OAB associated or not with DO. Both modulations decreased during bladder filling in incontinent women and during rest in OAB.

Dynamics of heart rate variability and the state of endogenous in toxication under different anesthesia regimens in dogs with visceral and somatic types of pain reaction

Dogs are naturally characterized by a high level ofinjuries, which can reach up to 50 % of the total surgicalpathology. At the same time, abdominal pathology issignificantly common in this species of animals andsurgical treatment of the sepathologies is accompanied bya significant somatic and visceral pain response. The workwas performed at the Department of Surgery and Diseasesof Small Pets of Bila Tserkva National Agrarian Universityin the period 2015-2020. The material for the study wereclinically healthy and sick dogs admitted to the clinic ofdiseases of small animals of the university. Forming theclinical-experimental base for research, nosological formsof pathology and frequency of its occurrence were taken into account, attention was paid to the peculiarities of surgicalintervention depending on the species of animals, type andintensity of pain response and correctness of anesthesia.Visceral type of pain reaction was studied in dogs aged2 to 10 years, who underwent abdominal surgery. Somaticpain reaction accompanies bone fractures and their surgicaltreatment. Included in the study of dogs with fractures of thefemur or humerus aged from 1 to 10 years.High levels of endotoxicosis are characteristic of thepathochemical phase of abdominal surgical pathology in dogs,with the concentration in the blood of malonic dialdehyde(14.8 ± 0.55 μmol / l) and molecules of average weight isrespectively 1.6 and twice higher than normal. However,the lowest level was found under balanced acepromazineketamine-propofol anesthesia, with no probable changes inmolecular weight peptides and a slight increase in the level ofmalonic dialdehyde only 1.1 times (p &lt;0,01).Acepromazine-butorphanol-propofol-ketamineanesthesia for somatic pain in dogs provides completeanalgesia with controlled and rapid recovery fromanesthesia without established probable changes during theoperation of spectral indicators of heart rate variability. Insomatic pain in dogs, regardless of the anesthesia regimen,the preoperative level of endotoxemia is preserved, andaccording to the spectral analysis of HRV and its sympathoparasympathetic balance index, 30 % of surgically ill dogsshow normotonia – 0.85–1.15, 27 – sympathicotonia (LF/HF&gt;1.15), in 43 % – parasimaticotonia (LF/HF&lt;0.85),which is the key criterion for selecting the appropriatescheme of anesthesia. Key words: heart rate variability, endogenousintoxication, anesthesia, dogs, types of pain reaction, visceralinnervation, somatic innervation.