Event Abstract Back to Event Correlation between Habituation of Visual Evoked Potentials and Magnetophosphene thresholds in migraine Anna Ambrosini1*, Aliaksei Kisialiou2, Ennio Iezzi1, Armando Perrotta1, Andrea Nardella1, Alfredo Berardelli3, Francesco Pierelli3 and Jean Schoenen4 1 IRCCS Neuromed, Pozzilli (Isernia), Italy, Italy 2 University of Glasgow, United Kingdom 3 University "La Sapienza", Italy 4 CHR CItadelle - University of Liège, Belgium Introduction: An interictal habituation deficit of visual evoked potentials (VEP) and a reduced threshold (PT) of magnetophosphenes have been reported in migraine in separate studies. While the habituation deficit was attributed to reduced preactivation level of the visual coretx, the reduced PT likely indicates cortical hyperexcitability. Both phenomena have not yet been explored in the same patients. Methods: We assessed PT by transcranial magnetic stimulation (TMS) in 15 healthy volunteers (HV) and in 13 episodic migraineurs without aura between attacks (MO), whereafter we recorded pattern-reversal VEP (6 blocks of 100 responses) and measured habituation. Results were compared using Mann-Whitney U test. Interrelationships were examined using Spearman’s correlation. Results: Phosphene thresholds was not significantly different between HV and MO. By contrast, MO patients had a reduced VEP habituation compared to HV (p=0.001). There was no correlation between PT and habituation in neither group of subjects . Conclusion: this study confirmed that migraineurs present interictally a deficit of VEP habituation, but failed to find decreased PT in these patients. VEP habituation and phosphene threshold values are not reciprocally correlated in healthy volunteers or in migraine patients, which suggest that they index different aspects of cortical excitability, i.e. a punctual measure of cortical activation threshold for PT, as opposed to a dynamic response pattern to repeated stimuli for VEP habituation. Keywords: Migraine Disorders, migraine pathophysiology, Evoked Potentials, Visual, transcranial magnetic stimulation cortical, phosphene threshold Conference: Belgian Brain Council 2014 MODULATING THE BRAIN: FACTS, FICTION, FUTURE, Ghent, Belgium, 4 Oct - 4 Oct, 2014. Presentation Type: Poster Presentation Topic: Clinical Neuroscience Citation: Ambrosini A, Kisialiou A, Iezzi E, Perrotta A, Nardella A, Berardelli A, Pierelli F and Schoenen J (2014). Correlation between Habituation of Visual Evoked Potentials and Magnetophosphene thresholds in migraine. Conference Abstract: Belgian Brain Council 2014 MODULATING THE BRAIN: FACTS, FICTION, FUTURE. doi: 10.3389/conf.fnhum.2014.214.00071 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 02 Jul 2014; Published Online: 16 Aug 2014. * Correspondence: Dr. Anna Ambrosini, IRCCS Neuromed, Pozzilli (Isernia), Italy, Pozzilli, Isernia, Italy, anna.ambrosini@neuromed.it Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Anna Ambrosini Aliaksei Kisialiou Ennio Iezzi Armando Perrotta Andrea Nardella Alfredo Berardelli Francesco Pierelli Jean Schoenen Google Anna Ambrosini Aliaksei Kisialiou Ennio Iezzi Armando Perrotta Andrea Nardella Alfredo Berardelli Francesco Pierelli Jean Schoenen Google Scholar Anna Ambrosini Aliaksei Kisialiou Ennio Iezzi Armando Perrotta Andrea Nardella Alfredo Berardelli Francesco Pierelli Jean Schoenen PubMed Anna Ambrosini Aliaksei Kisialiou Ennio Iezzi Armando Perrotta Andrea Nardella Alfredo Berardelli Francesco Pierelli Jean Schoenen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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