This paper presents the time history response of a sandwich beam with a porous core subjected to two moving harmonic loads with opposite directions. In the modelling, the beam is combined of two isotropic face sheets and a porous core with symmetric porosity distribution. The quasi-3D shear deformation beam theory in conjunction with Hamilton's variational principle is utilized to set up the governing equations of motion. The Navier solution is used to obtain the displacement field. The accuracy of the study is validated by comparing with existing results in the literature for specific cases. Effects of the velocity and excitation frequency of the moving loads on the deflection-time history are investigated and discussed. Numerical results reveal that in the case of the double-moving harmonic loads in the antiphase, the resonance phenomenon cannot occur when the excitation frequency approaches the natural frequency of the beam.