Dynamic capabilities in the supply chain play an essential role in improving an organization's operational performance. This research aims to see the influence of supply chain dynamic capabilities, including collaboration, integration, agility, and responsive capabilities, on the operational performance of food and beverage MSMEs in Sleman, Indonesia. The sample of this study is food and beverage MSMEs located in Sleman, Indonesia, which apply supply chain management capabilities such as collaboration, integration, agility, and responsive capabilities. The MSMEs must have been operated for more than three years, starting from 2019, so MSMEs already have a more robust supply chain network. Data from sixty food and beverage MSMEs was collected in 2024 using a set of questionnaires tested for validity using Pearson’s correlation and reliability using Cronbach’s Alpha. Data processing in this research uses SPSS 25 software with an analysis tool, namely multiple regression analysis. This analysis helps prove whether or not there is an influence between two or more independent variables on the dependent variable. The results of this research show that collaboration capabilities, integration capabilities, agility capabilities, and responsive capabilities partially have a significant positive effect on operational performance. Increasing collaboration capabilities between MSMEs and internal and external parties must be maintained to improve value from the MSMEs themselves. According to the hypothesis test results, the integration capability variable significantly influences the operational performance of MSMEs in Sleman, Indonesia. The agility capability variable significantly influences the operational performance of MSMEs in Sleman, Indonesia. The responsiveness significantly influences the operational performance of MSMEs in Sleman, Indonesia.