The exploitation/utilization of marine resources and the rapid development of urbanization along coastal cities result in serious marine pollution, especially underwater diffusion pollution. It is a non-trivial task to detect the source of diffusion pollution, such that the disadvantageous effect of the pollution can be reduced. With the vision of 6G framework, we employ Autonomous Underwater Vehicle (AUV) flock and introduce the concept of AUV-based network. In particular, we utilize the Software-Defined Networking (SDN) technique to update the controllability of the AUV-based network, leading to the paradigm of SDN-enabled multi-AUVs network Intelligent Transportation Systems (SDNA-ITS). For SDNA-ITS, we utilize artificial potential field theories to model the control model. To optimize the system output, we introduce the graph-based Soft Actor-Critic (SAC) algorithm, i.e., a category of Multi-Agent Reinforcement Learning (MARL) mechanism where each AUV can be regarded as a node in a graph. In particular, we improve the optimization model based on Centralized Training Decentralized Execution (CTDE) architecture with the assistance of the SDN controller, by which each AUV can efficiently adjust its speed towards the diffusion source. Further, to achieve exact path planning for detecting the diffusion source, a dynamic detection scheme is proposed to output the united control policy to schedule the SDNA-ITS dynamically. Simulation results demonstrate that our approaches are available to detect the underwater diffusion source when the actual scenario is taken into account and perform better than some recent research products.