This paper deals with the numerical analysis of ductile damage and fracture behavior under non-proportional biaxial reverse loading conditions. A two-surface anisotropic cyclic elastic–plastic-damage continuum model is adequately presented, which takes into account the Bauschinger effect, the stress-differential effect, and the change of hardening rate after reverse loading. An efficient Euler explicit numerical integration algorithm, based on the inelastic (plastic or plastic-damage) predictor-elastic corrector approach, is utilized to analyze the stress and finite strain loading histories. Detailed discussions are provided on different numerical integration-related consistent tangent operators that achieve convergence within the global Newton–Raphson scheme. The proposed continuum model is implemented into the commercial software Ansys as a user-defined subroutine (UMAT). Furthermore, the novel non-proportional biaxial tensile reverse experiments are performed to validate the proposed continuum model. The associated numerical simulations investigate the stability and accuracy of the proposed algorithm and material model.