ABSTRACT Aim Giant salivary gland stones (more than 15 mm) considered to be rare and a few of well-documented studies report it. In this literature, we report an asymptomatic, 15 mm sialolith in a 47-year-old man with whole procedure of treatment. Materials and methods A patient without symptom of Wharton's duct sialolith was detected and treated. Occlusal cross-sectional of mandibule film was used to guide of surgery, transoral approach was made to dissection of stone. Results Fifteen millimeters yellow sialolith was obtained, antibiotic therapy done for 1 week was after surgery and 2-month follow-up was done. Conclusion Sialoliths are responsible for the obstruction of salivary secretion. More than 80 to 90% of sialoliths, occurs in the submandibular glandular parenchyma or its duct. There is man predilection in parotid or submandibular sialolith. Giant salivary gland stones (more than 15 mm) considered to be rare and a few of well-documented studies report it. Removal of sialolith with intraloral approach is treatment of choice in the anterior duct submandibular gland. How to cite this article Begom JT, Azimi S, Rankohi ZE. Asymptomatic Large Sialolith of Wharton's Duct. Int J Experiment Dent Sci 2015;4(2):143-145.