Nitrate pollution of surface water from farms and urban runoff is widespread – impairing drinking water supplies, recreation, and wildlife habitat. The scale of the problem in rivers has overwhelmed most watershed-based best management practices. A new paradigm is needed. In this paper we highlight the 119 ha (294 acres) Prado Wetlands in southern California, USA as an example of a gravity-enabled, free surface flow vegetated wetlands to treat a river – the nitrate-rich, effluent-dominated Santa Anna River. The wetland treats ∼1–2 m3/s of the 7.1 m3/s (250 cfs) flow of the river in 28 wetland cells in two parallel trains (residence time 2–4 d, hydraulic loading rate 10–20 cm/d). The cleaner water is returned to the river and infiltrated downstream into a managed groundwater basin supplying 2.4 million customers. Since 1998, ∼1200 t of nitrate-N have been permanently removed from the river and released as N2-gas into the air. Over 24 years, in the warm summers an average of 6.1 mg-N/L entered the wetland and 3.7 mg-N/L flowed out, a removal efficiency of 57%. In the cooler winters, an average of 6.4 mg NO3-N/L entered and 2.6 mg NO3-N/L flowed out, a removal efficiency of 45%. Individual months varied widely in concentration removal efficiency from 7% (winter) to 98% (high summer). Areal summer removal averaged 137 mg NO3-N/m2/d and the apparent “k” was around 46 m/y. All-year rates were 129 mg NO3-N/m2/d or 47 g/m2/y, a reasonable performance considering the size of the system and its configuration for both nitrate removal and duck hunting (i.e., more open water). Annual average nitrate removal efficiency increased substantially over time (45 to 72% for 1998–2004 versus 2016–22) and is attributed to an increase in hydraulic residence time, upgraded internal plumbing, and increased winter temperatures (+3C°). Prado Wetlands also removes phosphorus, though not as well as nitrate; average warm season removal efficiency was 23% (inflow 1.20 mg PO4-P/L, outflow 0.93 mg PO4-P/L). The aerial removal rate was high at 23 mg P/m2/d or 8.5 g/y, probably due to the high inflowing P-concentrations and the hard water. Wildlife was also enhanced. Least Bell's Vireo (Vireo belli pusillus), an endangered bird in the Prado Basin, increased from 19 pairs (1998) to a recent average of 444 pairs due to habitat improvement and reduction of cowbird parasitism. Results from the Prado Wetlands show that cleaning up rivers via diversion through wetlands benefits both water quality and wildlife.