Abstract Progressive social movements correctly presume that justice demands treating people with humane regard: combining respect for human agency with concern for human vulnerability to suffering. Promoting humane regard is a critical means of acknowledging the moral claims of humanity. Some critics reject the underlying concept of a universal humanity, in virtue of which human beings form a distinct community of reciprocal moral obligation. Critics charge that the concept presumes indefensible dualisms (of mind and body, and humanity and nature); that it wrongly assigns a privileged status to reason; and that it involves an unsupportable belief in human exceptionalism. I argue that we can assert the moral claims of humanity without privileging reason, repudiating nature, or denying that there are many valuable ways to be human. I also defend an account of human moral exceptionalism that does not imply human moral superiority, to show that we can meet morally weighty obligations to humans while affirming morally substantive connections to non-human communities and domains.