Dual System Research Articles

Thermosensitive Injectable Dual Drug-Loaded Chitosan-Based Hydrogels for Treating Bacterial Endometritis.

Endometritis, a prevalent obstetric condition primarily caused by Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), significantly threatens the reproductive performance of female animals. In this study, thermosensitive injectable chitosan (CS)/β-glycerophosphate (β-GP) hydrogels loaded with berberine (BBR) and carvacrol (CAR) were prepared for endometritis treatment. In vitro, BBR/CAR-CS/β-GP hydrogels exhibited rapid gelation within 5 min at 37 °C, excellent injectability, and more than 90% degradation within 30 days under enzymatic action. The dual drug-loaded system also exhibited controlled release of BBR and CAR and demonstrated the antimicrobial activity against E. coli and S. aureus. In vivo, uterine injection of BBR/CAR-CS/β-GP hydrogels alleviated infection-induced injuries and reduced the bacterial load in infected uterine tissues. In summary, these findings highlight the potential of BBR/CAR-CS/β-GP hydrogels as innovative carriers for drug delivery targeting endometritis.

Dilations of (dual) frames for Krein spaces

This paper addresses the dilation problem on (dual) frames for Krein spaces. We characterize Riesz bases for Krein spaces and equivalence ([Formula: see text]-unitary equivalence) between frames for Krein spaces; prove that every frame (dual frame pair) for a Krein space can be dilated to a Riesz basis (dual Riesz basis pair) for a larger Krein space, and that the corresponding [Formula: see text]-orthogonal complementary frame ([Formula: see text]-joint complementary frame) is unique up to equivalence ([Formula: see text]-joint equivalence). Also we illustrate that two equivalent Parseval frames for Krein spaces need not be [Formula: see text]-unitarily equivalent and that not every Parseval frame can be dilated to a [Formula: see text]-orthonormal basis for a larger Krein space, and derive a result on matrices of finite size as application.

Closed-loop control strategy design for Caputo–Fabrizio definition-based fractional-order Boost converters considering parametric uncertainties

This paper proposes a dual closed-loop adaptive PI control system based on parameter identification for Caputo–Fabrizio (C-F) definition-based fractional-order boost converters. First, a C-F definition-based fractional-order model of the Boost converter is derived. Afterward, an online component parameter identification method is proposed to obtain the values and orders of capacitors and inductors in the proposed model. Based on these identified parameters, a dual closed-loop adaptive PI control system considering parametric uncertainties for the Boost converters is designed using the frequency domain analysis method. Finally, simulation validations are conducted. The online parameter identification method can accurately identify the values and orders of capacitors and inductors. The identification error is less than [Formula: see text] for the capacitance value and [Formula: see text] for the other parameters. Moreover, the proposed control system can automatically adjust the parameters with changes in the component parameters, effectively improving the robustness. Compared to traditional PI controllers, when the parameters of components change, the proposed control system can reduce voltage overshoot by [Formula: see text] in the case of sudden changes in the input voltage. These results confirm the efficacy of the proposed online parameter identification method and the dual closed-loop adaptive PI control system.

The In-Vivo Medial and Lateral Collateral Elongation Correlated with Knee Functional Score and Joint Space Following Unicompartmental Knee Arthroplasty.

The medial collateral ligament (MCL) and lateral collateral ligament (LCL) are paramount for joint stability. Their elongation patterns may change during fixed-bearing and mobile-bearing unicompartmental knee arthroplasty (FB and MB UKA). This study aims to explore the relationship between the elongation of MCL, LCL, and changes in joint space, as well as their correlation with functional scale scores during FB and MB UKA. We hypothesize that MCL and LCL have different elongation patterns in UKA patients, and there is a correlation between elongation and joint space and functional scores. The study recruited 24 patients undergoing UKA on a unilateral knee (13 FB and 11 MB). A dual fluoroscopic imaging system was employed to assess in-vivo knee kinematics during static standing and single-leg lunge. The superficial and deep MCL (sMCL, dMCL) and LCL were divided into anterior, medium, and posterior portions. The virtual ligament method quantified in-vivo ligament lengths. Analysis focused on the correlation of normalized ligament lengths with functional scores and joint space. 1. LCL Elongation in FB UKA: There is a significant increase in LCL elongation during early and mid-flexion of the single-leg lunge (p < 0.05). 2. MCL Elongation in MB UKA: Both sMCL and dMCL exhibit significant elongation during early and mid-flexion of the single-leg lunge (p < 0.05). 3. Correlation with Functional Scores: Differences in collateral ligament elongation in FB UKA are significantly correlated with the OKS and KSS, highlighting the impact on functional outcomes. In MB UKA, differences in ligament elongation are significantly correlated with the FJS. 4. Joint Space Correlation: There is a significant correlation between the elongation of the anterior and medium portions of dMCL and joint space in the surgical compartment during mid- and deep flexion (30-100 °, p < 0.05, r > 0.64). The study reveals distinct ligament elongation patterns between UKA and native knees in LCL for FB UKA and MCL for MB UKA. These patterns are associated with knee functional scores. Moreover, dMCL elongation correlates significantly with the joint space for MB UKA during middle and deep flexion phases. III; prospective retrospective cohort study.

Study on the Feasibility and Performance Evaluation of High-Orbit Spacecraft Orbit Determination Based on GNSS/SLR/VLBI

Deep space exploration utilizing high-orbit vehicles is a vital approach for extending beyond near-Earth space, with orbit information serving as the foundation for all functional capabilities. The performance of orbit determination is primarily influenced by observation types, errors, geometrical structures, and physical perturbations. Currently, research on orbit determination for high-orbit spacecraft predominantly focuses on single observation methods, error characteristics, multi-source fusion techniques, and algorithms. However, these approaches often suffer from low observation accuracy and increased costs. This paper advocates for the comprehensive utilization of existing multi-source observation methods, such as GNSS (Global Navigation Satellite System), SLR (Satellite Laser Ranging), and VLBI (Very Long Baseline Interferometry), in research. The decoupled Kalman filter reveals a positive correlation between measurement positioning accuracy and orbit determination accuracy, and it derives a simple orbit performance evaluation model that considers the influence of observation value types and geometric configurations, without the need to introduce complex dynamic models. Simulations are then employed to verify and analyze antenna gain, observation values, and performance evaluation. The results indicate the following: (1) Under simulated conditions, the optimal strategy involves employing the SLR/VLBI dual system during periods when VLBI orbit determination is feasible, yielding an average Weighted Position Dilution of Precision (WPDOP) of 26.79. (2) For periods when VLBI orbit determination is not feasible, the optimal approach is to utilize the GNSS/SLR/VLBI triple system, resulting in an average WPDOP of 16.32. (3) The orbit determination performance of the triple system is not significantly impacted by the use of global SLR stations compared to using only Chinese SLR stations. However, the global network enables continuous, round-the-clock orbit determination capabilities.

Islamic banking finance and private sector investment in dual banking systems: the impact of institutional quality

Islamic banking finance and private sector investment in dual banking systems: the impact of institutional quality

Gluing osteochondral fragments: development of a novel strategy for dual adhesive application in a preclinical model

This study proposes a novel dual adhesive approach for fixing osteochondral fractures, aiming to address the limitations of current fixation methods by incorporating both a bone adhesive (phosphoserine modified calcium phosphate cement PM-CPC) and a cartilage adhesive (methacrylated phosphoserine-containing gelatin MePGa hydrogel). The feasibility and efficacy of this approach were investigated using an ex vivo bovine knee model. Results indicate successful gluing of osteochondral cylinders with both adhesives, with no significant difference in adhesion strength between the groups (adhesion strength mean of 1211.6 kPa, SD 602.4 kPa, and mean of 1299.6 kPa, SD 850.9 kPa for groups 1 and 2 respectively). Importantly, the inclusion of the hydrogel component in the dual adhesive system aims to enhance cartilage repair potential, complementing the mechanical support provided by the bone adhesive. Each adhesive offers distinctive benefits: PM-CPC for mechanical support and bone repair, and MePGa hydrogel for cartilage repair. The study demonstrates the potential of the dual adhesive strategy for osteochondral repair, though further refinement and in vivo validation are needed.

Research on the effect of multiple credit ratings from the perspective of financial regulatory systems in Chinese bond market.

This paper, starting from the effects of financial regulatory policies, considers the interaction between Chengxin_Moody and Lianhe_Fitch with the dual rating system and the multi-rating system, constructs a new ordered Logit model, and attempts to explore the impact of the Notice, the dual rating system and the multiple rating system on the probability of Chinese corporate bond defaults, rating upgrades, rating downgrades, and the magnitude of credit rating migrations. This study compares the effectiveness of different rating regulatory systems. Using nine thousand two hundred and sixty-two data of Chinese corporate bonds as the research samples. Empirical analysis and robustness test reveal the following findings: (1) The issuance of the Notice has a significant positive effect on the implementation of both the dual rating system and the multiple rating system, with a greater impact on the implementation of the multiple rating system; (2) The issuance of the Notice, along with the dual rating system and the multiple rating system, can all reduce the probability of corporate bond defaults, with the multiple rating system showing the best preventive effect against corporate bond defaults; (3) The dual rating system is more effective in promoting rating agencies to adjust rating behaviors, accurately correcting corporate bond ratings and effectively alleviating the issue of rating inflation. Competition among rating agencies intensifies rating shopping; (4) Under the dual rating system, rating agencies are more likely to expand the magnitude of credit rating upgrades and downgrades, enhancing the differentiation between high-quality corporate bonds and junk corporate bonds; (5) The selection of rating information from Chengxin_Moody and Lianhe_Fitch can appropriately adjust the degree of flexibility or tightening in response to rating regulatory systems. Chengxin_Moody demonstrates a more sensitive reaction compared to Lianhe_Fitch regarding the rating regulatory systems. This study provides valuable references for the formulation and evaluation of the effectiveness of Chinese corporate bond rating regulatory policies.

Unveiling dynamic hepatocyte plasticity in HepaRG cells with a dual CYP reporter system.

Primary hepatocytes are widely utilized for investigating drug efficacy and toxicity, yet variations between batches and limited proliferation capacity present significant challenges. HepaRG cells are versatile cells, capable of maintaining an undifferentiated state and differentiating through dimethyl sulfoxide treatment, allowing for molecular analysis of hepatocyte plasticity. To elucidate the underlying molecular mechanisms of HepaRG cell plasticity, we used CYP3A4G/7R HepaRG cells engineered to express DsRed under the control of the fetus-specific CYP3A7 gene and EGFP under the adult-specific CYP3A4 gene promoter. In time-lapse imaging of CYP3A4G/7R HepaRG cells, we observed CYP3A7-DsRed expression transitioning from negative to positive during proliferation period and CYP3A4-GFP expression activating during differentiation. The de-differentiation potency of differentiated CYP3A4G/7R HepaRG cells was assessed using inhibitors and cytokines. It was found that Y-27632 (Y), A-83-01 (A), and CHIR99021 (C) (collectively referred to as YAC), which are known to promote liver regeneration in mice, did not induce CYP3A7-DsRed expression. Instead, these inhibitors increased CYP3A4-GFP expressing population. Furthermore, CHIR99021 alone increased CYP3A4-GFP-positive cells, while Wnt3a treatment increased CYP3A7-DsRed-positive cells, suggesting that Wnt signaling plays distinct roles in HepaRG cells. It was apparent that de-differentiated cells had increased CYP3A4 activity after a second round of differentiation, compared to differentiated cells after the first round. Transcriptomic analysis of HepaRG cells revealed distinct profiles between proliferative, differentiated, and de-differentiated states, highlighting their robust plasticity. Notably, hepatoblastic cells de-differentiated by YAC or C displayed transcriptome patterns similar to undifferentiated cells, whereas CYP3A7-DsRed and CYP3A4-GFP exhibited expression patterns different from those of undifferentiated cells. These findings underscore the dynamic nature of HepaRG cells while cautioning against solely relying on CYP3 family gene expression as a marker of differentiation.

QLTI-21. STREAMLINING THE STUDY INTAKE PROCESS AT THE CANCER CLINICAL AND TRANSLATIONAL RESEARCH OFFICE (CCTRO)

Abstract Challenges in the Protocol Intake/Activation process at the Henry Ford Cancer Center, particularly during the budget negotiation and coverage analysis (CA) phases, hamper operational efficiency and financial prospects. This study aimed to improve budget time and process efficiency. Process flow mapping, Value Stream Mapping (VSM), and cause-effect analysis using a fishbone diagram were used to identify and analyze key bottlenecks, focusing on the budget negotiation and CA phases. Budget negotiation took an average of 121.5 days in 2023 due to multiple procedures and a lack of standardized practices. Delays ranged from 127.75 days in August to a low of 69.84 days in November of 2023. The budget build process averaged 13.31 days, with an additional 7.57 days for approval, totaling 20.89 days. The CA phase had an average cycle time of 10.82 days (range 2-10 days). To improve approval times, it was recommended to implement an Electronic Document Management System to automate routing, signing, and tracking of budget and CA-related documents, standardized budget templates to streamline negotiations, a detailed electronic checklist to streamline task lists for document collection and budget negotiation, automated reminders for internal and external stakeholders to ensure timely submission of necessary documents, and timely submission policies enforced by a dedicated finance member on committees. Newly developed Key Performance Indicators (KPIs) such as ‘time to collect documents,’ ‘time between committees,’ and ‘time for budget negotiation process,’ along with a dual tracking system in Excel, were proposed to monitor and improve these metrics. The recommendations are expected to significantly enhance the efficiency of the Protocol Intake/Activation process. By reducing the budget negotiation phase to less than 60 days and optimizing the CA process, faster study initiation, better resource utilization, and improved responsiveness to research opportunities will be achieved. This study underscores the critical need to address operational challenges in clinical trial management to enhance CCTRO’s capability to conduct timely and effective research.

Unlimited Employee Autonomy over Working Time? The Potentially Empty Notion of Autonomous Workers in EU law

Digital technology is often associated with greater working time autonomy: in theory at least, digitalisation can result in workplaces where employees are less subordinate to their employers in terms of working time. Article 17(1) of Directive 2003/88/EC on certain aspects of the organisation of working time acknowledges that certain working time measures do not apply in case of ‘autonomous workers’. However, the Court of Justice of the European Union has interpreted this exception strictly, excluding from its scope workers who enjoy only partial autonomy over their working time. The aim of this study is to explore whether the EU concept of autonomous worker meets practical requirements or needs to be amended. In section 2, I argue for a more permissive interpretation, as a predominantly autonomous schedule could still justify some flexibility as regards working time rules. This interpretation would also better fit the dual system of subordinated employees and self-employed workers who enjoy more flexibility in the determination of the working hours. Under section 3, the article explores the various methods that employers use to maintain control over the organisation of working time in non-standard work environments. Research shows that the combination of different controlling measures can ensure that employers have a decisive influence over the measure and schedule of working time, even in nominally flexible working arrangements. Consequently, while a broader understanding of the concept of autonomous workers is suggested, it shall be carefully assessed in each case whether the worker actually enjoys autonomy in respect of working time.

The Role of Freeze-Drying as a Multifunctional Process in Improving the Properties of Hydrogels for Medical Use

Background/Objectives: Freeze-drying is a dehydration method that extends the shelf life and stability of drugs, vaccines, and biologics. Recently, its role has expanded beyond preservation to improve novel pharmaceuticals and their carriers, such as hydrogels, which are widely studied for both drug delivery and wound healing. The main aim of this study was to explore the multifunctional role of freeze-drying in improving the physicochemical properties of sodium alginate/poly(vinyl alcohol)-based hydrogels for medical applications. Methods: The base matrix and hydrogels containing a nanocarrier-drug system, were prepared by chemical cross-linking and then freeze-dried for 24 h at −53 °C under 0.2 mBa. Key analyses included determination of gel fraction, swelling ratio, FT-IR, SEM, TG/DTG, in vitro drug release and kinetics, and cytotoxicity assessment. Results: Freeze-drying caused an increase in the gel fraction of the hydrogel with the dual drug delivery system from 55 ± 1.6% to 72 ± 0.5%. Swelling ability was pH-dependent and remained in the same range (175–282%). Thermogravimetric analysis showed that freeze-dried hydrogels exhibited higher thermal stability than their non-freeze-dried equivalents. The temperature at 10% weight loss increased from 194.0 °C to 198.9 °C for the freeze-dried drug-loaded matrix, and from 188.4 °C to 203.1 °C for the freeze-dried drug-free matrix. The average pore size of the freeze-dried hydrogels was in the range of 1.07 µm ± 0.54 to 1.74 µm ± 0.92. In vitro drug release revealed that active substances were released in a controlled and prolonged way, according to the Korsmeyer–Peppas model. The cumulative amount of salicylic acid released at pH = 9.0 after 96 h was 63%, while that of fluocinolone acetonide reached 73%. Both hydrogels were non-toxic to human fibroblast cells, maintaining over 90% cell viability after 48 h of incubation. Conclusions: The results show a high potential for commercialisation of the obtained hydrogels as medical dressings.

MINARO DRS: usability study of a robotic-assisted laminectomy.

Although the literature shows that robotic assistance can support the surgeon, robotic systems are not widely spread in clinics. They often incorporate large robotic arms adopted from the manufacturing industry, imposing safety hazards when in contact with the patient or surgical staff. We approached this limitation with a modular dual robot consisting of an ultra-lightweight carrier robot for rough prepositioning and small, highly dynamic, application-specific, interchangeable tooling robots. A formative usability study with N = 10 neurosurgeons was conducted using a prototype of a novel tooling robot for laminectomy to evaluate the system's usability. The participants were asked to perform three experiments using the robotic system: (1) prepositioning with the carrier robot and milling into (2) a block phantom as well as (3) a spine model. All neurosurgeons could perform a simulated laminectomy on a spine phantom using the robotic system. On average, they rated the usability of this first prototype already between good and excellent (SUS-Score above 75%). Eight out of the ten participants preferred robotic-assisted milling over manual milling. For prepositioning, the developed haptic guidance showed significantly higher effectiveness and efficiency than visual navigation. The proposed dual robot system showed the potential to increase safety in the operating room because of the synergistic hands-on control and the ultra-lightweight design of the carrier robot. The modular design allows for easy adaptation to various surgical procedures. However, improvements are needed in the ergonomics of the tooling robot and the complexity of the virtual fixtures. The cooperative dual robot system can subsequently be tested in a cadaver laboratory and in vivo on animals.

Almost sure stability and stabilization of variable dual switching time-delay systems

Almost sure stability and stabilization of variable dual switching time-delay systems

Smartphone microscopy: Design and implementation of a dual magnification system

This paper presents a dual magnification smartphone microscope designed for versatile imaging, enabling low magnification for wide-field viewing and high magnification for detailed biological sample analysis and automatic control of the working distance. It offers a cost-effective alternative to traditional lab microscopes, particularly in low-resource settings. Simulated, optimized, and designed using Ansys Zemax OpticStudio, the microscope was fabricated with 3D printing technology. Dual magnification (150x and 1000x) was achieved with two optical paths, improving resolution to 1 µm at higher and 1.5 µm at lower magnifications. The design provides clear and accurate images. The smartphone integration enhances usability, allowing easy magnification switching, image capture, and potential use of diagnostic applications.

Rapid Dual-Gene Detection of Burkholderia gladioli and Subspecies Cocovenenans in Fresh Noodles and Tremella Using CRISPR-Cas12a/Cas13a.

Burkholderia gladioli pv. cocovenenans is a notable foodborne pathogen that poses a significant risk to food safety. Contaminated food requires distinct classification and treatment procedures for non-pathogenic B. gladioli and its pathogenic subspecies cocovenenans. Hence, establishing a rapid and sensitive detection method to distinguish them is necessary. In this study, we aimed to establish a method combining the CRISPR-Cas12a/Cas13a dual system with recombinase aided amplification for rapid, specific and sensitive detection of non-pathogenic B. gladioli and pathogenic subspecies cocovenenans in food. First, a RAA-CRISPR-Cas12a/Cas13a method was developed and its feasibility was assessed. Next, specificity was analyzed using 23 strains of B. gladioli and 5 non-target strains. Following this, sensitivity was evaluated by preparing gradient dilutions of B. gladioli pv. cocovenenans bacterial solutions. At last, real food test samples, including fresh noodles and tremella artificially contaminated with B. gladioli pv. cocovenenans, were utilized for method validation and sensitivity comparison. The established RAA-CRISPR-Cas12a/Cas13a method exhibited high specificity and achieved 100% accuracy in detecting species B. gladioli and its subspecies cocovenenans. This rapid method could be finished within 45 min with a detection limit of 10° CFU/mL for bacterial concentration. Additionally, it achieved detection limits of 102 CFU/g for fresh noodles and 103 CFU/g for tremella. The rapid RAA-CRISPR-Cas12a/Cas13a method demonstrated high specificity and sensitivity in detecting and disgusting species B. gladioli and subspecies cocovenenans in both food test samples and post-cultivation colonies. The RAA-CRISPR-Cas12a/Cas13a method presented in this study offers a novel molecular approach for the rapid, accurate and sensitive detection of B. gladioli and its subspecies cocovenenans in foods.

Do girls have a (moral) right to compete in sporting contests that exclude boys?

This paper explores the moral right of girls to compete in sporting contests that exclude boys, examining the ethical implications of gender segregation in sports. It argues that boys-only competitions are morally problematic, reinforcing gender stereotypes and perpetuating structural injustices. The paper also critiques open-division competitions, which can disadvantage girls due to inherent physiological differences. Through a review of historical and contemporary cases, the study highlights the necessity of girls-only competitions to ensure fairness and to challenge societal norms that undermine female athletes. The conclusion advocates for a dual system of girls-only categories alongside open divisions, allowing girls the choice to compete independently or alongside boys, depending on their preferences and aspirations.

The effect of manipulation under anesthesia on knee kinematics in individuals with arthrofibrosis after anterior cruciate ligament reconstruction.

Manipulation under anesthesia (MUA) has been recommended for refractory arthrofibrosis after anterior cruciate ligament (ACL) reconstruction. However, the effectiveness of MUA to restore normal kinematics of the arthrofibrotic knee is still unclear. The objective of this study was to evaluate tibiofemoral and patellofemoral kinematics in six degrees-of-freedom (6DOF) in patients with arthrofibrosis before and after MUA. Computed tomography and dual fluoroscopic imaging system were used to assess in vivo knee kinematics. Ten patients (6 women and 4 men; 32.6 ± 6.5y, 168.4 ± 7.8cm, 61.8 ± 13.2kg) were included in this study. The tibiofemoral and patellofemoral kinematics in 6DOF were collected before and one year after MUA. A simple analysis of variance was used to evaluate kinematic data of preoperative arthrofibrotic knee, postoperative arthrofibrotic knee, and the contralateral knee. The patella in the postoperative arthrofibrotic knee shifted significantly more inferiorly compared to the preoperative knee at 45° (P = 0.010), 60° (P = 0.008), and 75° (P = 0.049) of flexion. The patellar flexion in the postoperative arthrofibrotic knee significantly increased at 45° (P = 0.048), 60° (P = 0.037), and 75° (P = 0.006) of flexion compared to the preoperative arthrofibrotic knee. The patellar tilt was significantly decreased at 60° (P = 0.006) and at 75° (P = 0.037) of knee flexion in the postoperative arthrofibrotic knee compared to the contralateral knee. MUA significantly increased tibial internal rotation angle in the arthrofibrotic knee at 45° (P = 0.047), at 60° (P = 0.033), and at 75° (P = 0.021) of knee flexion. MUA could restore normal patellar inferior shift, flexion, and tibial rotation compared to the contralateral side. However, the MUA could not restore normal patellar tilt of the arthrofibrotic knee. This indicated that improvement of patellar tilt should be emphasized in postoperative rehabilitation.

The next challenge in emissions control for heavy-duty diesel vehicles: From NOx to N2O

Vehicle emissions are a major source of greenhouse gases globally. Dual selective catalytic reduction (SCR), an advanced version of single SCR, is crucial under stricter nitrogen oxide (NOx) emission standards for heavy-duty diesel vehicles (HDDVs). However, the emission characteristics of nitrous oxide (N2O), a byproduct of SCR and a potent greenhouse gas, remain unclear. This study investigates the N2O emissions from HDDVs equipped with single or dual SCR systems using heavy-duty chassis dynamometers under various ambient temperatures, altitudes, and loading masses. The results showed that the brake-specific emissions (EFb) of N2O from HDDVs with single and dual SCRs were 76.28–269.65 mg/kWh and 147.50–170.22 mg/kWh, respectively. Notably, the dual SCR-equipped HDDV emitted 6–22 times more N2O than NOx under all tested conditions. As ambient temperature increased from −10 °C to 25 °C and from 25 °C to 40 °C, the average distance-based emission factors (EFd) of N2O for the single SCR-equipped HDDV increased by 87.73% and 48.26%, respectively. However, the variation was not significant for the dual SCR-equipped HDDV. Under half- and full-load conditions, the average EFd of N2O for the single SCR-equipped HDDV increased by 47.57% and 110.92%, respectively, compared to those without loading. Similarly, N2O emissions for dual SCR-equipped HDDV increased by 41.40% and 65.37% under the same loading variations. As altitude increased from 0 m to 3000 m, the average EFd of N2O for the single SCR-equipped HDDV decreased by 64.31%. Additionally, N2O emissions were significantly affected by SCR temperature, engine power, and nitric oxide (NO)/nitrogen dioxide (NO2) ratio. These findings are crucial for setting future greenhouse gas limits of HDDVs and informing carbon reduction strategies.

Dualities for rational multi-particle Painlevé systems: Spectral versus Ruijsenaars

The extension of the Painlevé–Calogero correspondence for the n -particle Inozemtsev systems raises to the multi-particle generalisations of the Painlevé equations. This extension may be obtained by the Hamiltonian reduction applied to the matrix Painlevé systems. Additionally, such procedure gives an isomonodromic formulation for these non-autonomous Hamiltonian systems. We provide dual systems for the rational multi-particle Painlevé systems ( P_{\textup{I}} , P_{\textup{II}} and P_{\textup{IV}} ) using the Hamiltonian reduction. We describe this duality in terms of the spectral curve of a non-reduced system compared to the Ruijsenaars duality.