Deoximation reaction is one of the most essential transformations in organic synthesis for the precise chemical manufacturing of carbonyl compounds. Developing catalytic deoximation techniques is highly demanding for environmental protection and minimizing expenses in fine chemical operations. Herein, we have reported an environmentally friendly, low-cost, and sustainable approach for regenerating carbonyl compounds from numerous oxime derivatives using microwave irradiation. The method uses I2 and an aqueous solution ofAcacia auriculiformis as the green solvent. The concentration ofAcacia auriculiformiswas discovered to correlate with the percentage production of carbonyl compounds. However, using the dual-surfactant system deliberately improved the regeneration of carbonyl compounds with up to 82% yield at 60:40 ratio. With DFT analysis and quantum chemical parameters, the chemical reactivity and electronic properties of the surfactant systems were determined. Also, the mechanistic interpretation of the actual reaction in the micellar core is depicted, which is well supported by the computational analysis. Overall, our method is green, low-cost, energy-saving, and avoids using toxic reagents and solvents.